ID A0A087YGP3_POEFO Unreviewed; 821 AA.
AC A0A087YGP3;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=RAS protein activator like 1 {ECO:0000313|Ensembl:ENSPFOP00000017196.2};
GN Name=RASAL1 {ECO:0000313|Ensembl:ENSPFOP00000017196.2};
OS Poecilia formosa (Amazon molly) (Limia formosa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000017196.2, ECO:0000313|Proteomes:UP000028760};
RN [1] {ECO:0000313|Proteomes:UP000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA Schartl M., Warren W.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPFOP00000017196.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AYCK01000983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AYCK01000984; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007564909.1; XM_007564847.2.
DR AlphaFoldDB; A0A087YGP3; -.
DR STRING; 48698.ENSPFOP00000017196; -.
DR Ensembl; ENSPFOT00000017218.2; ENSPFOP00000017196.2; ENSPFOG00000017018.2.
DR GeneID; 103146796; -.
DR KEGG; pfor:103146796; -.
DR CTD; 8437; -.
DR eggNOG; KOG2059; Eukaryota.
DR GeneTree; ENSGT00940000158715; -.
DR OMA; VTRAGVW; -.
DR OrthoDB; 24454at2759; -.
DR Proteomes; UP000028760; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd05135; RasGAP_RASAL; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037776; RASAL_RasGAP.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF3; RASGAP-ACTIVATING-LIKE PROTEIN 1; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..105
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 116..235
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 305..515
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 570..677
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 752..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 93037 MW; B09BAC4EBCA1F68B CRC64;
MAQNTSLYFR IVEGRNLPAK DVSGTSDPYC IVKVDNEVVA RTATVWKNLN PFWGEEFTLH
LPMGFHSLSF LVMDEDTIGH DDVIGKITLS KEAIGSQAKG LDSWMNLTRV DPDEEVQGEI
HLSLELLKDT TKSSLRCQVI EARDLAPRDI SGTSDPFGRI IFNNHSAETS IIKKTRFPHW
GETLELELDA EELNEEGTVV VEVWDWDMVG KNDFLGKVEI PFASLHKTPV LEGWFRLLPL
GNNEADASGK LGALRLKVRL VEDRILPSTY YQPLIELLVE SVISPAEVED SSALTMLEEV
TTVESRQDVA MTLVKIYLGQ GLVVPFLDYL NTREVNHTTD PNTLFRSNSL ASKAMEQFMK
AVGMLYLHEV LKPIINRIFD ERKYIELDPC KIDLNRTRRI SFKSGVSEAE VRDFSVEMLQ
TYLTSIIESI VSSVDQCPSV MRVAFKQLHK RVEEQFTEPE NEDVKYLAIS GFFFLRFFAP
AILTPKLFQL RDQHADTRTS RTLLLLAKAL QSVGNLGLQL GHGKEQWMSP LHPIILSSVA
SVKDFLDKLI DVDHDIVSSV PQRAVFMPSV TVKEGYLHKH KAEGPQLLSR FAFKKRYFWL
TSETLSYAKT SDWQVRSSIP IQRVCAVERV DENAFQQQNV MQVITQDNDG KLNTMYIQCK
NVNELNQWLS AIRKVSIYNE RMLPSFHPGV HRSGKWTCCL QADRAVSGCS RTHSAVTLGD
WSDPLDPDVE TQMIYKQLLQ GRDKLRKKYL EMEEADPTSS NKETRISPDI HPDGAECNAP
PMRPGQSVAA RLLVVIEDLE QAHATFQLRE IEDATRVILN P
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