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Database: UniProt
Entry: A0A087YHP3_POEFO
LinkDB: A0A087YHP3_POEFO
Original site: A0A087YHP3_POEFO 
ID   A0A087YHP3_POEFO        Unreviewed;      4852 AA.
AC   A0A087YHP3;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   28-MAR-2018, entry version 26.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSPFOP00000017546};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000017546, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000017546, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000017546};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000017546}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AYCK01000221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AYCK01000225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000017568; ENSPFOP00000017546; ENSPFOG00000016822.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4181   4208       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4394   4414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4461   4480       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4603   4629       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4652   4674       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4733   4756       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      105    160       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      167    212       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      220    274       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    343       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      591    802       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1033   1213       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1259   1469       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3931   3957       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     2829   2849       {ECO:0000256|SAM:Coils}.
FT   COILED     3400   3420       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4852 AA;  548307 MW;  067821384CD6295B CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQSVATILK EHRKFCLAAE GLGNRLCYLE PTSEAKYVPP
     DMCICNFVLE QSLSVRALQE MLANTGTSSE GKADHEKWAG QGGGHRTLLY GHAILLRHSF
     SDMYLTCLKT SRSLTDKLSF DVGLQEDSVG EACWWTIHPA SKQRSEGEKV RIGDDLILVS
     VSTERYLHLS NCNGNIQVDA SFMQTLWNVQ PTCSSGSMAV GYLIGGHVMR LCHGHDESLT
     IPGADKSEEE QRIVNYEAGK GASRARSLWR LEPLRISWSG SHIRWGQSFR LRHLSTGRYL
     ALTEDRGLVL EDREKCHTKA TAFCFKPSKE KGDSGMKRDI DGMGVPEIKY GDSVCFVMHV
     ATGLWLSYLA PDAKSSRLGP LKRRACLHSE GHMDDGLILQ RCQHEESRAA RIIRNTTFLF
     KNFIKALDSA AAGETNAVAG YVEEVLQTLN DLIEYFKQPD VDLEHEEKQA RLRSLIKQQD
     LFKEEGMLAL LSKCIDRMNL YDSAAHFGEM AGEEAGAAWK DILNLLYELL AALIRGNRTN
     CTQFSRNLDW LVSKLERMES SSGILEVLHC ILVESPEALN IIQKGHIKSI ISLLYKHGRN
     HKILDVLCSL CVCNGVAVRT NQNLICDNLL PKRDLLLQTR LVNDVQSMRP NIFLGIAEGS
     AQYKKWYYEL VIDQVDHFVT GEPTHLRVGW ANTKGYAPYP GGGEGWGGNG VGDDLYSYSF
     DGLHLWSGRI PRAVASINQH LLNSDDVVSC CLDLGAPSMS FRINGQPVQG MFEDFNTDGF
     FFPVVSFSAG VKARFLLGGR HGDFKFLPPA GYSPCYEALL PKEKMHVEPV KEYKRDHDGV
     RDLLGTTQFL SQASFIPTPV DTSQIVLPPH LENIRDKLAE NIHELWGMNK IELGWTYGKV
     RDDNKRQHPC LVDFSKLPET EKNYNVQMSS ETLKTLLALG CHVAQVNVHA EEDLKKIKLP
     KDYMMSNGYK PAPLELSDVK LTPGQEVLVD KLAENAHNVW AKDRIKQGWT YGIQQDVKSR
     RNPRLVPYAL LDERTKKSNR DSLREAIRTM VGYGYDIDPP DQEVVHAIDN QSIETIRFFR
     VEQTYAVKTG KWYFEFEVLS GGDMRVGWAR PGCRPDVELG TDDQAYVFDG YRGRRMHAGS
     RYFGHPWKKG DVVGCMINME DKSMIFTLNG ELLITSKGSE LGFADFETED GFIPVCSLGM
     SQIGHMNLGK DASTFKYYTM CGLQEGFEPF AVNMNREITM WFSKRLPTFF NVPQDHMHIE
     VTRIDGTVDS PPCLKVTHKT FGTQNSNSDM VYCRLSMPVE FYSADRLLDE SLKLSQPPKE
     DGSIDYGSIT TYYHSVRVFA GQDPASVWVG WVTPDYHYYS KNFSLSKTQT VTVTLGDERG
     RVHESIQRSN CYMVCAADAL GPSSSSRSNT DLEIGCLVDL ATGLVSFTAN GKELPTAYQV
     EPNTKLFPAV FCCPTSSNLF QFEFVKIKDA MPLSSAMFRS EQRNPVPQCP PRLDVQTIVA
     VLWSRMPNTF LNVETARVSE RHGWVVQCLE PLQMMAVHIP EENRCLDIME LSEHEDLRKF
     HSHTLKLYCA LCALGNTRVA HALCSHLDQS QLLYTIDNQY LSGMLREGFY DVLISIHLET
     AKEARLMMNN EFIIPVTDET RSIKLFPDES KRHSLPGVGL STSLKPRVNF SPVGIISTKR
     HQLLYSPQIP LGILKEKAIS MLTEAVQGGG SHIRDPVGGS LEYQFVPILK LIGTLLIMGV
     LTSDEVRLIL LLIEPNVFGE AKEGEEGSEV VVAGEKEEVS KNEEKAVEAG EEETKESKPA
     AKGLLEKSLP ESVKHQMCEL LHYFCDCELQ HRIEAIVSFS DRFVSKLQYN QKFRYNELMQ
     AFNMSAAVTA KKTKEFRSPP HEQINILLNF SAGEDCPCPE EIQDELTSFH EELRLHCGIP
     VEEQEEEQDT SIKGRLLALL YKIKGPPQKT EEQPAETEQA APTNLKELIS QTITSWAQES
     HIQNPELVRV MFSLLRRQYD GIGELLRAMK KSYTISAASV QDGINLLVSL GQIRSLLSVR
     MGKEEEKLMI DGLGDIMNNK VFYQHPNLMR VLGMHETVME VMVNVLGGDK SQEIAFPKMV
     ASCCRFLCYF CRISRQNQKA MFDHLSYLLE NSSVGLASEA MRGSTPLDVA ASSVMDNNGL
     ALALEEPDLE KVVMYLAGCG LQSCAILVAK GYPDLGWNPI EGERYLSFLR FVVFCNGESV
     EENANVVVKL LIRRPECFGP ALRGEGGQGL LAAMKEAIKI SEDPALDLPK SPAGATAGSG
     EEEGEVIHMG NAIMSFYSAL IDLLGRCAPE MHLINAGKGE ALRIRAILRS LVPTSDLVGI
     ISIPLKMPVI NKDGSVTEPD MSACFCPDHK APMVLFLDRV YGIEDQSFLL QMLEVGFLPD
     LKASASLDTE VLSTTETALA MNRYIGSALL PLLTRCAALF GNTEHYAHLV DSTLETIYRL
     SKGRSLTKAQ RDAIEECLLA ICKHLRPSMM QQLLRRLVFD VPLLTEYCKM PLRLLTNHYE
     QNWKYYCLPS GMGGFGMASE EELLLTKKLF WGIFDSLSQK KYDSELFKMA KSCLCAIAGA
     LPPDFVDTSL GATVEKQESV DAQGNFEPKP INTANISLPE KLDYIANKYA EHSHDKWASE
     KMSAGWKHGD SLDEQAKAHP LLKPYKSLSE KERETYRWPV KESLKSMLAM NWNIERTKEG
     EAMFQQRESE KQRKLSETQS NGFSPAPMDL HNVTLSRELQ SMVEVVAENY HNIWAKKKKS
     ELLSKGGGLA HPLLVPYDTL TAKEKYRDKE KAQELFKFLQ ISGYAITRGL KDMEQDSSSM
     EKRFAYKFLK RLLKNIDSAQ EFIAHLEAMA TSGKTDKSPH DQEIKFFAKV LLPLIDQTFK
     NHCLYFLSTP SKNLSSCGCA SNKEKEMLTS LFCKMAALVR HRISLFGSDS AIMVSCLHIL
     SHSLDTRTVM KSGAELVKVG FKAFFENAAE DLEKLVEMLK LGKFMQSRAQ MKSVTQSINY
     VTVALLPILT ALFEHTRTHE FDVDLLVDDV QLSCYRILMC FYSLGTGKNV FVERHLPAIG
     ESLATLVGAM PVAFLEPHLN AHNPLSVFNT KTPRERAILS MPDTVEEMCP EMPRLDKLLK
     DVNDVSECGA RYSDMPQVIE VVLPMLCNYL SYWWEKGPEN SPPDTDCCTM VTSEHLSIIL
     GNILKILNNN LGIDDAPWMK RIAVYSQPII CKAGADLLRT HFLPTMEKLK KKTVKVVSEE
     ELLKADGKGD NQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRSRWLKE PDADSTELFR
     MVAEIFILWC KSNNFKREEQ NFVIQNEINN LGFLTGEGKS KMSKSGGDQE RKHKRRRGEY
     YSIQTSLIVA ALKKLLPIGL NMCTPGDQEL ISLAKIRYSL KDTDDEVKEH LRQNLHLQEK
     SDDPAVHWQL NLYKDVVVKS EEPSDSEHTV DRIQSISAAV FNLEQVEQPL RNKKCIVQKL
     LSKQRKRAVV ACFRMAPLYN LPRHRAINFF IPAYERLWIA AEEYSFEEKL VQDLAKTPMK
     IVEEEEEEVA EIKPDPLHQL ILHFSHNALT ERSHLEVDPL YIAYADMMAK SCAEDEEEEE
     EEGREKTFEE KEMEKQKILY QQARLHARGA AEMVLQMISA SKGRLGPMVT CTLKLGISIL
     NGGNVQVQQK MLGYLTDKRD AGFFKSLSGL MQSCSVLDLN AFERQNKAEG LGMVTEEGSI
     NTQRGSKVLQ NDEFTKDLFR FLQLLCEGHN GDFQNFLRTQ TGNTTTVNII ISTVDYLLRL
     QESISDFYWY YSGKDVIDET GKHNFSKALS VAKQIFNSLT EYIQGPCIGN QQSLAHSRLW
     DAVVGFLHVF ANMQMKLSQD ASQIELLKEL MDLQKDMVVM LLSLLEGNVV NGTIGKQMVD
     TLVESSSNVE MILKFFDMFL KLKDLTTSDN FKEYDPECKG IISKKEFQKS MESQKQYNQS
     EIEFLLSCAE ADENDMFNYK EFVERFHEPA KDIGFNVAVL LTNLSEHMPH DTRLATFLDL
     AESVLSYFEP YLGRIEILGS AKRIERVYFE ISESSREQWE KPQVKESKRQ FIFDVVNEGG
     ESEKMEMFVN FCEDTIFEMQ LASQISEPDA VEQPEEEEEE EVHNILEELS GGDAAALEST
     SAFTTACRSV KKSLSEIRQI FTIKTARKQF KKIKKLSIKE LITGFFSFFW MIFIGFFKGI
     ISLVFGFFHV IWSSMFGGGL VEGAKNIKVT DILGNMPDPT QFGIHGDVGE GDKVEAMESS
     GSLDKAMAPA GDATEVDVML EMLTPKKEGG KHVEPGLGDV SELSGESSAA DSKKKAAAKT
     AAPSESETEK ADTETREKED KPKEEEAKEP AVEEKPKPRS SQPKEASPAF MSTVFAILDV
     YLNKILNYLA RNFYNLRFLA LFVCFAINFI LLFYKVTGEA EEEEEDEENH WGDDDDENTL
     FDMDEFVLQE STGYMLPTLR FLAIFHTVIS LLCLVGYYCL KVPLVVFKRE KEIARKLEFD
     GLYITEQPSD DDIKGQWDRL VINTPSFPNN YWDKFIKRKV INKYGDMYGA ERIAELLGLD
     KSALDFDPTV ETVEKEASLL SWLSSIDTKY HIWKLGVVLT DNYFLYLIWY TTMSIFGHFN
     NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA VVVYLYTVVA FNFFRKFYNK
     SEDEDEPDMK CDDMMTCYLF HMYVGVRAGG GIGDELEDPA GDPYELYRIL FDITFFFFVI
     VILLAIIQGL IIDAFGELRD QQEQVKEDME TKCFICGIGN DYFDRTPHGF ETHTLQEHNL
     ANYLFFLMYL INKDETEHTG QESYVWKMYQ ERCWDFFPAG DCFRKQYEDQ LG
//
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