ID   A0A087YIA2_POEFO        Unreviewed;       449 AA.
AC   A0A087YIA2;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=cysteine desulfurase {ECO:0000256|ARBA:ARBA00012239};
DE            EC=2.8.1.7 {ECO:0000256|ARBA:ARBA00012239};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000017755.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000017755.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU004504};
CC   -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC       aminotransferase family. NifS/IscS subfamily.
CC       {ECO:0000256|ARBA:ARBA00006490}.
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DR   EMBL; AYCK01002435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007547131.1; XM_007547069.2.
DR   AlphaFoldDB; A0A087YIA2; -.
DR   STRING; 48698.ENSPFOP00000017755; -.
DR   Ensembl; ENSPFOT00000017777.2; ENSPFOP00000017755.2; ENSPFOG00000017650.2.
DR   GeneID; 103134694; -.
DR   KEGG; pfor:103134694; -.
DR   CTD; 9054; -.
DR   eggNOG; KOG1549; Eukaryota.
DR   GeneTree; ENSGT00940000155740; -.
DR   OMA; KGLYWAR; -.
DR   OrthoDB; 212394at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0031071; F:cysteine desulfurase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0044571; P:[2Fe-2S] cluster assembly; IEA:InterPro.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   HAMAP; MF_00331; Cys_desulf_IscS; 1.
DR   InterPro; IPR000192; Aminotrans_V_dom.
DR   InterPro; IPR020578; Aminotrans_V_PyrdxlP_BS.
DR   InterPro; IPR010240; Cys_deSase_IscS.
DR   InterPro; IPR016454; Cysteine_dSase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR02006; IscS; 1.
DR   PANTHER; PTHR11601:SF34; CYSTEINE DESULFURASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR   Pfam; PF00266; Aminotran_5; 1.
DR   PIRSF; PIRSF005572; NifS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00595; AA_TRANSFER_CLASS_5; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760}.
FT   DOMAIN          52..413
FT                   /note="Aminotransferase class V"
FT                   /evidence="ECO:0000259|Pfam:PF00266"
SQ   SEQUENCE   449 AA;  50107 MW;  FEA749FE86CAD1C7 CRC64;
     MLSPGRTISS RLLRPASWLP FRLCPERTAV NSMQKELIKK HELEKDELRP LYMDFQATTP
     MDPRVLDAML PYQVNYYGNP HSRTHAYGWE SETAMETARK QVADLIGADP REIIFTSGAT
     ESNNMAIKGV ARFYQAKKRH VITTQTEHKC VLDSCRILEA EGFEVTYLPV QTNGLLDLQL
     LESSIRPETS LVSVMTVNNE IGVKQPIEEI GQICRSKGVF LHTDAAQAVG KIPISVSDWK
     VDLMSISGHK IYGPKGVGAL YVRRRPRVRL EPLQSGGGQE RGLRSGTVPT PLAVGLGAAC
     SISQKEMEYD HQRVSMLANR LVQKIMSEIP DVVMNGDPEQ RYPGCINLSF AYVEGESLLM
     ALKDVALSSG SACTSASLEP SYVLRAIGAD EDLAHSSIRF GIGRFTTEQE VDYTAEKCIQ
     HVRRLREMSP LWEMVQEGID LKSIKWTQH
//