ID   A0A087YL68_POEFO        Unreviewed;       500 AA.
AC   A0A087YL68;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Dyskerin pseudouridine synthase 1 {ECO:0000313|Ensembl:ENSPFOP00000018771.2};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000018771.2, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000028760};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000018771.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
CC       {ECO:0000256|ARBA:ARBA00008999}.
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DR   EMBL; AYCK01018994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007578215.1; XM_007578153.2.
DR   AlphaFoldDB; A0A087YL68; -.
DR   SMR; A0A087YL68; -.
DR   STRING; 48698.ENSPFOP00000018771; -.
DR   Ensembl; ENSPFOT00000018793.2; ENSPFOP00000018771.2; ENSPFOG00000018653.2.
DR   GeneID; 103156185; -.
DR   KEGG; pfor:103156185; -.
DR   CTD; 1736; -.
DR   eggNOG; KOG2529; Eukaryota.
DR   GeneTree; ENSGT00510000047092; -.
DR   OMA; CIVRLHD; -.
DR   OrthoDB; 5472308at2759; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:Ensembl.
DR   CDD; cd02572; PseudoU_synth_hDyskerin; 1.
DR   CDD; cd21148; PUA_Cbf5; 1.
DR   Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR   Gene3D; 2.30.130.10; PUA domain; 1.
DR   InterPro; IPR012960; Dyskerin-like.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR002501; PsdUridine_synth_N.
DR   InterPro; IPR002478; PUA.
DR   InterPro; IPR015947; PUA-like_sf.
DR   InterPro; IPR036974; PUA_sf.
DR   InterPro; IPR004802; tRNA_PsdUridine_synth_B_fam.
DR   InterPro; IPR032819; TruB_C.
DR   InterPro; IPR004521; Uncharacterised_CHP00451.
DR   NCBIfam; TIGR00425; CBF5; 1.
DR   NCBIfam; TIGR00451; unchar_dom_2; 1.
DR   PANTHER; PTHR23127; CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5; 1.
DR   PANTHER; PTHR23127:SF0; H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1; 1.
DR   Pfam; PF08068; DKCLD; 1.
DR   Pfam; PF01472; PUA; 1.
DR   Pfam; PF16198; TruB_C_2; 1.
DR   Pfam; PF01509; TruB_N; 1.
DR   SMART; SM01136; DKCLD; 1.
DR   SMART; SM00359; PUA; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR   SUPFAM; SSF88697; PUA domain-like; 1.
DR   PROSITE; PS50890; PUA; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          43..101
FT                   /note="Dyskerin-like"
FT                   /evidence="ECO:0000259|SMART:SM01136"
FT   DOMAIN          292..366
FT                   /note="PUA"
FT                   /evidence="ECO:0000259|SMART:SM00359"
FT   REGION          418..500
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..500
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   500 AA;  55995 MW;  F5E6A28605C28147 CRC64;
     MADLEASVKK KKKSKKVLEE SVGEIQQSGD FFIQPESIAP SLDTSQWPLL LKNFHKLNIR
     TAHYTPIPCG SNPLKRNITD YVKSGFINLD KPANPSSHEV VAWIRRILRV EKTGHSGTLD
     PKVTGCLIVC IDRATRLVKS QQSAGKEYVG IVRLHNAIES EHVLARALET LTGALFQRPP
     LIAAVKRQLR VRTIYESKLI EYDPERRLGI FWVSCEAGTY IRTLCVHLGL LLGVGGQMQE
     LRRVRSGVLG EKDNLVTMHD VLDAQWQFDH NKDETYLRRV IFPLEKLLVS HKRLVMKDSA
     VNAICYGAKI MLPGVLRYED GIEVNQDIVV ITTKGEAICT AVALMTTAVI STCDHGVVAK
     IKRVIMERDT YPRKWGLGPK ASQKKMMIQK GLLDKHGKPN GSTPQDWKDQ YVDYSASSVA
     ASGDASAKRK RESAESDSEP AQPSTPSAED VKKEKKKKKK EKKAKLEEAE TEKTEEEPDT
     PVAEKPKKKK KKQKESELAE
//