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Database: UniProt
Entry: A0A087YLU9_POEFO
LinkDB: A0A087YLU9_POEFO
Original site: A0A087YLU9_POEFO 
ID   A0A087YLU9_POEFO        Unreviewed;      2063 AA.
AC   A0A087YLU9;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 2.
DT   25-OCT-2017, entry version 22.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Poecilia formosa (Amazon molly) (Limia formosa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae;
OC   Poeciliinae; Poecilia.
OX   NCBI_TaxID=48698 {ECO:0000313|Ensembl:ENSPFOP00000019002, ECO:0000313|Proteomes:UP000028760};
RN   [1] {ECO:0000313|Ensembl:ENSPFOP00000019002, ECO:0000313|Proteomes:UP000028760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSPFOP00000019002};
RA   Schartl M., Warren W.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPFOP00000019002}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2014) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSPFOP00000019002}.
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DR   EMBL; AYCK01000456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSPFOT00000019024; ENSPFOP00000019002; ENSPFOG00000018820.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; LIQVERP; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000028760; Unassembled WGS sequence.
DR   GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
DR   GO; GO:0097470; C:ribbon synapse; IEA:Ensembl.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Ensembl.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR   GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028760};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028760};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     59     76       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     96    115       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    206    227       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    290    311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    323    345       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    463    481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    501    524       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    593    612       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    670    692       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    826    844       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    856    875       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    942    972       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1026   1047       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1067   1094       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1146   1166       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1178   1197       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1284   1302       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1375   1399       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1533   1567       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2063 AA;  234339 MW;  1E8EF66DAD78391A CRC64;
     SSTIPVGALA QKKRQQYAKS KKQGSNANSR PPRALFCLKL NNPLRRACIS VVEWKPFDIF
     ILIAIFANCM ALAVYVPFPE DDSNSTNHDL ETVEYAFLII FTIETFLKII AYGLVMHQNA
     YVRNGWNMLD FVIVVIGLFS VVLEFLTKDE KGEGDGESSH PSTHGHGGKP GGFDVKALRA
     FRVLRPLRLV SGVPSLQVVL NSIIKAMVPL LHIALLVLFV IIIYAIIGLE LFIGKMHATC
     YIGGTADLIA EEDPAPCAIS GHGRQCPING TQCREGWHGP NGGITNFDNF LFAMLTVFQC
     ITMEGWTDVL YWMNDAMGFE LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS KEREKAKARG
     DFQKLREKQQ LEEDLKGYLD WITQAEDIDP DNEDEAEEGS KRNPSVPASE TESVNTENQN
     VEDEKTPCCG PLCQKISKSK FSRRWRRWNR FCRRKCRLAV KSVPFYWLVI ILVFLNTLTI
     SSEHYNQPLW LTQVQDVANK VLLALFTCEM LVKMYSLGLQ AYFVSLFNRF DCFVVCGGIT
     ETILVELEIM SPLGISVFRC VRLLRIFKVT RHWQSLSNLV ASLLNSMKSI ASLLLLLFLF
     IIIFSLLGMQ VFGGKFNFDE TQTKRSTFDN FPQALLTVFQ ILTGEDWNAV MYDGIQAYGG
     PSSSGMVVCF YFIILFICGN YILLNVFLAI AVDNLADAES LNTDEGDKKD ICHMCGKSTY
     KDFLKITGTK RMMRKMKRYY HILFNHQTKT NIPIYCNTIV EEEEEDNDEN GGDEEDPEVP
     SGPRPVIADL VKKEKIIPIP EGSAFFIFSS TNPVRVFCHQ LINHHIFTNL ILVFIMLSSV
     SLAAEDPIRN FSARNIVLGY ADYVFTSMFT FEIVLKMTTY GAFLHKGAFC RNYFNLLDLL
     VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV
     TTLLQFMFAC IGVQLFKGKF YRCTDEAKSS PDECKGTYIL YKDGDVNQPT IHRRVWHNSD
     FNFDNVLMAM MALFTVSTFE GWPALLYKAI DSNRENLGPI YNYRVEISIF FIIYIIIIAF
     FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV
     VNSTGFEYIM FVLIMLNTLC LAVQHYGQSA LFNYVMDILN MVFTAVFTVE MVLKLIAFKP
     RHYFADAWNT FDALIVVGSV VDIAITEVNS AEHYQCTSNQ NTEDSARISI TFFRLFRVMR
     LVKLLSRGEG IRTLLWTFIK SFQALPYVAL LIAMLFFIYA VIGMQVFGKI AMVDGTQINR
     NNNFQTFPQA VLLLFRCATG EAWQEIMLAC MPGKLCDPES DYNPGEEMTC GSGFAIIYFI
     TFYMLCAFLI INLFVAVIMD NFDYLTRDWS ILGPHHLDEF KRIWSEYDPE AKGRIKHLDV
     VTLLRRIQPP LGFGKLCPHR VACKRLVAMN MPLNSDGTVM FNATLFALVR TALKIKTEGN
     LEQANEELRA VIKKIWKRTS MKLLDQVVPP AGDDEVTVGK FYATFLIQDY FRKFKKRKEE
     GLVTAHPSQN NTAIGLQAGL RTLHDIGPEI RRAISCDLQD DELVDFIPEE DEEIYRRNGG
     LFGNHLMNGG HRRANGHQTN TTQRPLQVQP PPHYAHMEQP VGRLSRANAM DSYGKSPKST
     NINLNNANMS SLPNGGHHIY YERAPPNGYP GLRTSYYDYN KPRTPQEFIS FISWLKFATK
     CKHHSLSSSY IYIKMLLTSQ GIDVAFSLKL SDDVFTEVLS SVSFLQASNG MSNYYDDDEQ
     PLYRDSRRSP KRRLLPATPQ GHRRPSFNFE CLRRQSSQDE LPHQRTALPL HLMQHQVMAV
     AGLDSSRAHC LSPTRSTRSW ATPPATPASK DQSPYYTPLI RVDRPHRESI SGSHVSVRKS
     SWYTDDPEYS QRTYSPIHLQ VPPEYHHQYH QKRGSATSLV EAVLISEGLG RYAKDPKFVA
     ATKHEIADAC EMTIDEMESA ASHLLSEGIA PGINGVNVFP LLAPRDYELP DTGASYSDEE
     PETESRAPYE EDLADEMICI TTL
//
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