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Database: UniProt
Entry: A0A087ZRG8_APIME
LinkDB: A0A087ZRG8_APIME
Original site: A0A087ZRG8_APIME 
ID   A0A087ZRG8_APIME        Unreviewed;       484 AA.
AC   A0A087ZRG8;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 14.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata;
OC   Apoidea; Apidae; Apis.
OX   NCBI_TaxID=7460 {ECO:0000313|EnsemblMetazoa:GB41386-PA, ECO:0000313|Proteomes:UP000005203};
RN   [1] {ECO:0000313|EnsemblMetazoa:GB41386-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DH4 {ECO:0000313|EnsemblMetazoa:GB41386-PA};
RA   Wu J.L., Liu J.H., Yuan Y.N., Qiao L.Y., Liu W.Z.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GB41386-PA}
RP   IDENTIFICATION.
RC   STRAIN=DH4 {ECO:0000313|EnsemblMetazoa:GB41386-PA};
RG   EnsemblMetazoa;
RL   Submitted (JAN-2017) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   STRING; 7460.GB15121-PA; -.
DR   PaxDb; A0A087ZRG8; -.
DR   EnsemblMetazoa; GB41386-RA; GB41386-PA; GB41386.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005203};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005203};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM     42     65       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM     85    110       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    180    201       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    213    236       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    287    305       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    412    437       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   484 AA;  55107 MW;  E4528FA50D614044 CRC64;
     MVTFEDPPTY NRTNKFTKGF QALIDAYGVA SYREMNPSPY TIITFPFLFA VMFGDTGHGL
     LMFLFGGWMV LKEKPLAAKK SDNEIWNIFF GGRYIIFLMG LFSMYTGLIY NDIFSKSLNI
     FGSYWRINYN FSTIDSNKEL QLNPSDKEQY LQIPYPIGMD PVWQLAENKI IFLNSYKMKI
     SIIFGVIHML FGVVIGLWNH MYFKRKLNIT CEFIPQIIFL VFLFLYMVLL MFIKWIKYGP
     DSDKIDPEHG PSCAPSVLIT FINMVLFKPG TAPKPCSPWM YGGQSGFQSF LVVIAVLCIP
     WMLLAKPIML MNNRKKQHYQ LNNHGTENGD VEGAVDAIQP ANGVPQGGGH KEEEEDMAEV
     FIHQGIHTIE YVLGSVSHTA SYLRLWALSL AHAQLSEVLW NMVMRNGLTQ EGWAGGIIIW
     AVFALWAVLT VGILVLMEGL SAFLHTLRLH WVEFQSKFYS GLGYGFQPFS FEIILDAAQS
     TAED
//
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