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Database: UniProt
Entry: A0A087ZV49_APIME
LinkDB: A0A087ZV49_APIME
Original site: A0A087ZV49_APIME 
ID   A0A087ZV49_APIME        Unreviewed;      2085 AA.
AC   A0A087ZV49;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   27-SEP-2017, entry version 23.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata;
OC   Apoidea; Apidae; Apis.
OX   NCBI_TaxID=7460 {ECO:0000313|EnsemblMetazoa:GB42728-PA, ECO:0000313|Proteomes:UP000005203};
RN   [1] {ECO:0000313|EnsemblMetazoa:GB42728-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DH4 {ECO:0000313|EnsemblMetazoa:GB42728-PA};
RA   Wu J.L., Liu J.H., Yuan Y.N., Qiao L.Y., Liu W.Z.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:GB42728-PA}
RP   IDENTIFICATION.
RC   STRAIN=DH4 {ECO:0000313|EnsemblMetazoa:GB42728-PA};
RG   EnsemblMetazoa;
RL   Submitted (JAN-2017) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   STRING; 7460.GB12929-PA; -.
DR   PaxDb; A0A087ZV49; -.
DR   EnsemblMetazoa; GB42728-RA; GB42728-PA; GB42728.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   Proteomes; UP000005203; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005203};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005203};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    144    171       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    215    237       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    273    295       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    404    426       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    800    823       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    844    867       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    873    897       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    928    951       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1008   1029       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1289   1307       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1327   1346       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1353   1376       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1407   1425       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1446   1475       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1588       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1651   1669       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1681   1700       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1712   1731       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1775   1798       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1865   1888       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1905   1940       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       24     49       {ECO:0000256|SAM:Coils}.
FT   COILED      430    468       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2085 AA;  236834 MW;  A0FBCC3D3B755E44 CRC64;
     MSEDSDSVSE EERSLFRPFT RESLAAIEAR IAEEHAKQKE LEKKRAEGEG GFGRKKKKKE
     VRYDDEDEDE GPQPDPMLEQ GAPIPVRLHN EFPPELASTP LEDIDSFYHN QRTFVVISKG
     KDIFRFSATD AMWILDPFNP IRRVAIYILV HPLFSLFIIT TILVNCILMI MPTTPTIEST
     EVIFTGIYTF ESAVKVMARG FILQPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT
     FRVLRALKTV AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC
     IKNFPEDGSW GNLTDENWER FVSNETNWYV DEAKNMPLCG NSSGAGQCLP GYTCLQGYGE
     NPNYGYTSFD TFGWALLSAF RLMTQDYWEN LYQLVLRSAG PWHMLFFIVI IFLGSFYLVN
     LILAIVAMSY DELQKKAEEE EAAEEEAIRE AEEAALAKEN KLAAQAAARE AAAHAAVTAA
     DQIVKSPSDF SCHSYELFVG QEKGNDDNNK ERMSIRSIES VSEHRVKQIN NHTTTTKVRK
     VSAVSRAANG QFTYAYQESL RKASLSLPGS PFNLRRSSRG SHQFTIRNGR GRFVGPPGGD
     RKPLVLSTFL DAQEHLPYAD DSNAVTPMSE ENGTIVVPVY YANLGSRHSS YTSHASRLSY
     TSHGDLIGGI ANAGKPMTKE SQLRIRSVRP PSVNGHITDN NQKYHYEGDL EDAMGKAKQQ
     DNPFIEPSQQ HAVVDMKDVM VLNDIIEQAA GRQSRTPEQG DDDEEGPTFK DKLLTAVLRC
     IDIFCVWDCC WLWLEFQKYV ALLVFDPFVE LFITLCIVVN TLFMALDHHD MDKDMERVLK
     TGNYFFTATF GIEATLKLIA MSPKFYFQEG WNIFDFIIVA LSLLELGLEG VQGLSVLRSF
     RLLRVFKLAK SWPTLNLLIS IMGRTVGALG NLTFVLCIII FIFAVMGMQL FGKNYTDNVD
     RFPDGDLPRW NFTDFMHSFM IVFRVLCGEW IESMWDCMLV GDVSCIPFFL ATVVIGNLVV
     LNLFLALLLS NFGSSNLSAP TADNDTNKIA EAIDRIARFV KWIKRNVLYL AKMMRAKLTN
     QISDQAPDGI DRDGDLDLAD GELDAYRDKK SAKELNQLEV AIGDGMEFTI HGDLKNKLKK
     GKLCMNNSKV IANSINHRDY RLDNDYINQN EDDTISNKSY GSHKNRAFKD ESHKGSMDSL
     DGEEKKDASK EDLEQEEDLG EEGEEGEGVI GDAIIQAEED PIESDYPADC CPENCYKKFP
     FLAGDDDAPF WQGWANLRLK TFQLIENKYF ETAVILMILL SSMALALEDV HLQQRPILQD
     ILYYMDRIFT VIFFIEMLIK WLALGFKKYF TNAWCWLDFI IVMLSLINLG AIWAGAADIP
     AFRSMRTLRA LRPLRAVSRW EGMRVSLINF VASLCGAGGI QAFKTMRTLR ALRPLRAMSR
     MQGMRVVVNA LVQAIPSIFN VLLVCLIFWL IFAIMGVQLF AGKYFKCVDA NKTTLSHEII
     PDRNACLAEN YTWENSPMNF DHVGKAYLCL FQVATFKGWI QIMNDAIDSR ELNKQPIRET
     NIYMYFYFVF FIIFGSFFTL NLFIGVIIDN FNEQKKKAGG SLEMFMTEDQ KKYYNAMKKM
     GSKKPLKAIP RPRWRPQAIV FEIVTDKKFD MIIMLFIGLN MLTMTLDHYQ QTQTFSDVLD
     YLNMIFIVIF TSECLMKIFA LRYHYFKEPW NLFDFVVVIL SILGLVLSDI IEKYFVSPTL
     LRVVRVAKVG RVLRLVKGAK GIRTLLFALA MSLPALFNIC LLLFLVMFIF AIFGMSFFMH
     VKDKSGLDDV YNFKTFGQSM ILLFQMSTSA GWDGVLDGII NEEDCQEPNN EIGYPGNCGS
     STIGIAYLLS YLVISFLIVI NMYIAVILEN YSQATEDVQE GLTDDDYDMY YEIWQQFDPD
     GTQYIRYDQL SDFLDVLEPP LQIHKPNKYK IVSMDIPICK GDMMFCVDIL DALTKDFFAR
     KGNPIEETAE IEVQTRPGET GYEPVSSTLW RQREEYCARL IQNAWRKHKQ QRLGGPSEES
     DDADTDPRVR QTAVLVESDG FVTKNGHRVV IHSRSPSVTS RTADV
//
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