ID A0A089LYY6_9BACL Unreviewed; 768 AA.
AC A0A089LYY6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=PSTEL_26475 {ECO:0000313|EMBL:AIQ66132.1};
OS Paenibacillus stellifer.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=169760 {ECO:0000313|EMBL:AIQ66132.1, ECO:0000313|Proteomes:UP000029507};
RN [1] {ECO:0000313|EMBL:AIQ66132.1, ECO:0000313|Proteomes:UP000029507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14472 {ECO:0000313|EMBL:AIQ66132.1,
RC ECO:0000313|Proteomes:UP000029507};
RA den Bakker H.C., Tsai Y.-C., Martin N., Korlach J., Wiedmann M.;
RT "Comparative genomics of the Paenibacillus odorifer group.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
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DR EMBL; CP009286; AIQ66132.1; -; Genomic_DNA.
DR RefSeq; WP_038699713.1; NZ_CP009286.1.
DR AlphaFoldDB; A0A089LYY6; -.
DR STRING; 169760.PSTEL_26475; -.
DR KEGG; pste:PSTEL_26475; -.
DR HOGENOM; CLU_363634_0_0_9; -.
DR OrthoDB; 9775096at2; -.
DR Proteomes; UP000029507; Chromosome.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR InterPro; IPR001119; SLH_dom.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 2.
DR Pfam; PF00395; SLH; 3.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 2.
DR PROSITE; PS51272; SLH; 3.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Reference proteome {ECO:0000313|Proteomes:UP000029507};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..768
FT /note="beta-lactamase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001846791"
FT DOMAIN 587..650
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
FT DOMAIN 651..709
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
FT DOMAIN 712..768
FT /note="SLH"
FT /evidence="ECO:0000259|PROSITE:PS51272"
SQ SEQUENCE 768 AA; 81421 MW; 602C5A07BEE51B8A CRC64;
MRKKSRSLKV LTAVTLSAAL LLPSVQAPSA YAAASGEHLT GLATVLQPII DAAEEHGVGV
SVDIEDLSGT YGHETIELGS QDAYYSASII KLALIATLMQ EVDAGQHTLD ETLTVKPEDV
VGGAGSLQKE KFPQDVTIGR LAKLMITQSD NTATNVLIGL VGFDKVNAFI KSQGFTVTHL
GRKMMTPAKS PAEDNYTSAP EMLTLLDRIY NAEVVSAKSR DQILEWMKAQ EVNTKFGAVL
QGKPIAHKTG ELGDVSHDVG YFLIPGREIA IAVLTKVLKP EDAGKAQELD NPYVQRIAKA
TYNYLSDHPS SAASTASAWP AMSLAVAPII DAAEREGIRV SVDIKDLSGQ AGGAEVLLGS
RQSYMPASTI KMALVSTLMQ QVDKGALTLG QKVTVEPDDV VGGTGSLQKE TFPQDVTIER
LARLMITQSD NTATNVLIDV VGLDKVQALM DQLGLKTMHL GRKMFAAAPT PAQDNYIDAA
DLVTLLAKIY NHEFLSTQSS EQIINWMKAQ EVNTKFGAAL PDAPIAHKTG ENANVTHDVG
YFLVPGKEVA ISVMTEVTTT GSFDEAQAIG NPVVQSVAKA VYSSLTNNVK FTDVKPGYWA
ESLIESAAAA NVVKGSTSST FSPERDITRA EFVSLLARSL GLAASTGGQP FADVPSEAWY
ASDVAAAQAA GIALGSDGSF RPNASISRAE VMSLITRAYE YKHGKVAVPS AAASFKDGKS
IPSWASEAVA KAVSLQLVNG YPDGTLRPGN PATRAEAVKL IADLRFQL
//
