GenomeNet

Database: UniProt
Entry: A0A089X684_STRGA
LinkDB: A0A089X684_STRGA
Original site: A0A089X684_STRGA 
ID   A0A089X684_STRGA        Unreviewed;       615 AA.
AC   A0A089X684;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   30-AUG-2017, entry version 25.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AIR99372.1};
GN   ORFNames=SGLAU_17030 {ECO:0000313|EMBL:AIR99372.1};
OS   Streptomyces glaucescens.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1907 {ECO:0000313|EMBL:AIR99372.1, ECO:0000313|Proteomes:UP000029482};
RN   [1] {ECO:0000313|Proteomes:UP000029482}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GLA.O {ECO:0000313|Proteomes:UP000029482};
RX   PubMed=25499805; DOI=10.1016/j.jbiotec.2014.11.036;
RA   Ortseifen V., Winkler A., Albersmeier A., Wendler S., Puhler A.,
RA   Kalinowski J., Ruckert C.;
RT   "Complete genome sequence of the actinobacterium Streptomyces
RT   glaucescens GLA.O (DSM 40922) consisting of a linear chromosome and
RT   one linear plasmid.";
RL   J. Biotechnol. 194:81-83(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP009438; AIR99372.1; -; Genomic_DNA.
DR   EnsemblBacteria; AIR99372; AIR99372; SGLAU_17030.
DR   KEGG; sgu:SGLAU_17030; -.
DR   KO; K02313; -.
DR   Proteomes; UP000029482; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029482};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029482}.
FT   DOMAIN      308    436       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      522    591       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     316    323       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   615 AA;  67601 MW;  3A4B1D7DBCD185C4 CRC64;
     MEAKDEHWIR RCQPLALVAD TALLAVPNEF AKGVLEGRLA PIVSETLSRE CGRPIRIAIT
     VDDSAGEPPA PAPAPPAPPA QPRYEEPELP SGPYEQGYGR HRAEPLPGTD DQQLPAARPA
     YPGEYQRPEP GGWPRPAQDE YGWQQPRLGF PERDPYATPP QDAYRSPAQD TYGSGGGEGY
     GSQPGDGYGR HRHAPSHDYR PQGTDRPPYD QQRTEHGPSR GDYEQQDGRR DLPEPASGSP
     AHRGQGGAAP SASGAPGPLA AQPAPAAGPG EPTARLNPKY LFDTFVIGAS NRFAHAAAVA
     VAEAPAKAYN PLFIYGESGL GKTHLLHAIG HYARSLYPGT RVRYVSSEEF TNEFINSIRD
     GKGDSFRKRY REMDILLVDD IQFLADKEST QEEFFHTFNT LHNANKQIVL SSDRPPKQLV
     TLEDRLRNRF EWGLITDVQP PELETRIAIL RKKAVQEQLN APPEVLEFIA SRISRNIREL
     EGALIRVTAF ASLNRQPVDL GLTEIVLKDL IPGGEDSAPE ITSTAIMGAT ADYFGLTVED
     LCGTSRGRAL VTARQIAMYL CRELTDLSLP KIGALFGGRD HTTVMHADRK IRNLMAERRS
     IYNQVTELTN RIKNG
//
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