ID A0A089YK86_9PSED Unreviewed; 855 AA.
AC A0A089YK86;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=LT40_00575 {ECO:0000313|EMBL:AIS15979.1};
OS Pseudomonas rhizosphaerae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=216142 {ECO:0000313|EMBL:AIS15979.1, ECO:0000313|Proteomes:UP000029499};
RN [1] {ECO:0000313|EMBL:AIS15979.1, ECO:0000313|Proteomes:UP000029499}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16299 {ECO:0000313|EMBL:AIS15979.1};
RX PubMed=25483321; DOI=10.1016/j.jbiotec.2014.11.031;
RA Kwak Y., Jung B.K., Shin J.H.;
RT "Complete genome sequence of Pseudomonas rhizosphaerae IH5T (=DSM 16299T),
RT a phosphate-solubilizing rhizobacterium for bacterial biofertilizer.";
RL J. Biotechnol. 193:137-138(2015).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP009533; AIS15979.1; -; Genomic_DNA.
DR RefSeq; WP_043185150.1; NZ_CP009533.1.
DR AlphaFoldDB; A0A089YK86; -.
DR STRING; 216142.LT40_00575; -.
DR KEGG; prh:LT40_00575; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_6; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000029499; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000029499}.
FT DOMAIN 687..703
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 613..620
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 855 AA; 94216 MW; 21E1504F074E9F88 CRC64;
MSDFSNHTPM MQQYWKLKNQ HPDQLMFYRM GDFYEIFYED AKKAAKLLDI TLTARGQSAG
QSIPMCGIPY HAAEGYLAKL VKLGESVVIC EQIGDPATSK GPVDRQVVRI ITPGTVSDEA
LLDERRDNLI AAVLGDERLF GLAVLDITSG SFMVMELAGW ENLLAELERI NPVELLIPDD
WPQGLPAEKR KGSRRRAPWD FERDTAHKSL CQQFATQDLK GFGCEKLTLA IGAAGCLLGY
AKETQRTALP HLRSLRHERL DDTVVLDGAS RRNLELDTNL AGGRDNTLQS VIDRCQTAMG
SRLLTRWLNR PLRDLKVLQA RQGSISCLLE GYRFESLQPQ LKEIGDIERI LARIGLRNAR
PRDLARLRDA LAALPELQVA MAELEAPHLA QLAAIAGTYP ELADLLAKAI VDNPPAVIRD
GGVLKTGYDS ELDELLSLSE NAGQFLIDLE AREKARTGLS HLKVGYNRVH GYFIELPSKQ
AEQAPADYIR RQTLKGAERF ITPELKEFED KALSAKSRAL AREKSLYEAL LENLISHLPP
LQDTAAALAE LDVLSNLAER ALNLDLNRPR FVDEPCLRID QGRHPVVEQV LTTPFVANDL
SLDDSTRMLV ITGPNMGGKS TYMRQTALIV LLAHIGSFVP AAGCELSLVD RIFTRIGSSD
DLAGGRSTFM VEMSETANIL HNATERSLVL MDEVGRGTST FDGLSLAWAA AECLAGLRAY
TLFATHYFEL TVLPESQPLV ANVHLSATEH NERIVFLHHV LAGPASQSYG LAVAQLAGVP
GTVIQRAKEH LSRLETTSLP HEAPAAMPGK KATPHQADLF ASLPHPVLEQ LAKTDIDGLT
PRQALELLYA LKNRV
//
