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Database: UniProt
Entry: A0A090IQI2_9BACI
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ID   A0A090IQI2_9BACI        Unreviewed;       448 AA.
AC   A0A090IQI2;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   25-OCT-2017, entry version 26.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CED99877.1};
GN   ORFNames=B4064_2256 {ECO:0000313|EMBL:KIO66366.1}, B4065_2611
GN   {ECO:0000313|EMBL:KIO65313.1}, B4166_2370
GN   {ECO:0000313|EMBL:KIO67674.1}, B4167_2216
GN   {ECO:0000313|EMBL:KIO73362.1}, BT1A1_0001
GN   {ECO:0000313|EMBL:CED99877.1};
OS   Bacillus thermoamylovorans.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=35841 {ECO:0000313|EMBL:CED99877.1, ECO:0000313|Proteomes:UP000040576};
RN   [1] {ECO:0000313|EMBL:CED99877.1, ECO:0000313|Proteomes:UP000040576}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Wibberg Daniel;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000032071, ECO:0000313|Proteomes:UP000032076, ECO:0000313|Proteomes:UP000032078}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4064 {ECO:0000313|EMBL:KIO66366.1,
RC   ECO:0000313|Proteomes:UP000032078}, B4065
RC   {ECO:0000313|EMBL:KIO65313.1, ECO:0000313|Proteomes:UP000032071},
RC   B4166 {ECO:0000313|EMBL:KIO67674.1,
RC   ECO:0000313|Proteomes:UP000032097}, and B4167
RC   {ECO:0000313|EMBL:KIO73362.1, ECO:0000313|Proteomes:UP000032076};
RA   Krawcyk A.O., Berendsen E.M., Eijlander R.T., de Jong A.,
RA   Wells-Bennik M., Kuipers O.P.;
RT   "Draft Genome Sequences of Four Bacillus thermoamylovorans Strains,
RT   Isolated From Food Products.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CCRF01000001; CED99877.1; -; Genomic_DNA.
DR   EMBL; JXLS01000057; KIO65313.1; -; Genomic_DNA.
DR   EMBL; JXLR01000045; KIO66366.1; -; Genomic_DNA.
DR   EMBL; JXLT01000051; KIO67674.1; -; Genomic_DNA.
DR   EMBL; JXLU01000049; KIO73362.1; -; Genomic_DNA.
DR   RefSeq; WP_034766745.1; NZ_JXLU01000049.1.
DR   EnsemblBacteria; CED99877; CED99877; BT1A1_0001.
DR   EnsemblBacteria; KIO65313; KIO65313; B4065_2611.
DR   EnsemblBacteria; KIO66366; KIO66366; B4064_2256.
DR   EnsemblBacteria; KIO67674; KIO67674; B4166_2370.
DR   EnsemblBacteria; KIO73362; KIO73362; B4167_2216.
DR   PATRIC; fig|35841.6.peg.3644; -.
DR   Proteomes; UP000032071; Unassembled WGS sequence.
DR   Proteomes; UP000032076; Unassembled WGS sequence.
DR   Proteomes; UP000032078; Unassembled WGS sequence.
DR   Proteomes; UP000032097; Unassembled WGS sequence.
DR   Proteomes; UP000040576; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000032071,
KW   ECO:0000313|Proteomes:UP000032076, ECO:0000313|Proteomes:UP000032078,
KW   ECO:0000313|Proteomes:UP000032097};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000040576}.
FT   DOMAIN      144    272       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      356    425       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     152    159       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   448 AA;  50989 MW;  306ACE1121CC8116 CRC64;
     MENIDDLWGK TLNVIEKKIS KPSFETWLKS TKAIALNKNT LIVEAPNDFA REWLDGNYKE
     ILTEILYELI GENMSLKFVI PESNMDDPIM VSPANKKPAK PEVITDSAQH MLNPKYTFET
     FVIGSGNRFA HAASLAVAEA PAKAYNPLFI YGGVGLGKTH LMHAIGHYVL EHNPMAKVVY
     LTSEKFTNEF INSIRDNRPD DFRNKYRNVD ILLIDDIQFL AGKESTQEEF FHTFNTLHEE
     NKQIIISSDR PPREIPTLED RLRSRFEWGL ITDITPPDLE TRIAILRKKA KADGLDIPNE
     VMLYIANQID SNIRELEGAL IRVVAYSSLE NKDINADLAA EALKSIIPSS KPRVITIQDI
     QRVVGEQFGV KLEDFSAKKR TKSIAFPRQI AMYLSRELTD FSLPKIGEEF GGRDHTTVIH
     AHEKISNLIK TDPQFQKQIQ ELENKLKI
//
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