ID A0A090IUZ2_9BACI Unreviewed; 664 AA.
AC A0A090IUZ2;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN ECO:0000313|EMBL:CEE01517.1};
GN ORFNames=B4166_0379 {ECO:0000313|EMBL:KIO70969.1}, B4167_0497
GN {ECO:0000313|EMBL:KIO74219.1}, BT1A1_1689
GN {ECO:0000313|EMBL:CEE01517.1};
OS Caldibacillus thermoamylovorans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Caldibacillus.
OX NCBI_TaxID=35841 {ECO:0000313|EMBL:CEE01517.1, ECO:0000313|Proteomes:UP000040576};
RN [1] {ECO:0000313|EMBL:CEE01517.1, ECO:0000313|Proteomes:UP000040576}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wibberg Daniel;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000032076, ECO:0000313|Proteomes:UP000032097}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B4166 {ECO:0000313|EMBL:KIO70969.1,
RC ECO:0000313|Proteomes:UP000032097}, and B4167
RC {ECO:0000313|EMBL:KIO74219.1, ECO:0000313|Proteomes:UP000032076};
RA Krawcyk A.O., Berendsen E.M., Eijlander R.T., de Jong A., Wells-Bennik M.,
RA Kuipers O.P.;
RT "Draft Genome Sequences of Four Bacillus thermoamylovorans Strains,
RT Isolated From Food Products.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; CCRF01000048; CEE01517.1; -; Genomic_DNA.
DR EMBL; JXLT01000005; KIO70969.1; -; Genomic_DNA.
DR EMBL; JXLU01000010; KIO74219.1; -; Genomic_DNA.
DR RefSeq; WP_034769971.1; NZ_JXLU01000010.1.
DR AlphaFoldDB; A0A090IUZ2; -.
DR PATRIC; fig|35841.7.peg.3431; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000032076; Unassembled WGS sequence.
DR Proteomes; UP000032097; Unassembled WGS sequence.
DR Proteomes; UP000040576; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000040576}.
FT DOMAIN 208..326
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 478..620
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 410..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..430
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 75123 MW; 5556BD617BB7D2EB CRC64;
MGKIIQLDEV LSNKIAAGEV VERPASVVKE LVENAIDAGS TMIEVEVEEA GLKKIRVIDN
GSGIEPEDVP LAFERHATSK IKDEKDLFRI KSLGFRGEAL PSIASVAKVE LVTSTGSGPG
SRLVVEGGTK LLFEPAPSRK GTDFTVTDLF FNTPARLKYM KTIHTELGNI TDVMNRLALS
HPEVAMKLIH NGRTLLQTTG NGDSRQVLAG IYGLNIVKKM IPIHGESLDF QVDGYITLPE
VTRASRNYIS IMVNGRFIKN YPISNAVIAG YHTLLPIGRF PIVYLNITMD PILVDVNVHP
AKLEVRLSKE KELSELITET IKQSFKKETL IPAGQAPKQE KLKSEQISLS LDHLPENLGQ
QDEPFDQKRE KVARSNIDNG HSTLTKEERT VAGLFLQSLK EHESVNEIKE SEESFHQTNH
NQEENFDKVT ENSIGENLNG IDLDEATNEK KAHDDHEPFD NNPDFTKQPV SRIPVLYPIG
QMHGTYIFAE NEKGLYIIDQ HAAQERIKYE YFKEKIGEVS NDLQELLIPL TLQFSNDEFI
KLEENLEELK KVGLFLEPFG TNTFIIRNHP QWFPRGEEEE TIQEIIEQVL TMKKVDIKKL
REETAIMMSC KGSIKANHRL RHDEIQQLLD TLRMTSDPFT CPHGRPIIIH FSTYEMEKMF
KRVM
//
