ID   A0A090KZ76_STRRB        Unreviewed;      1537 AA.
AC   A0A090KZ76;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012494};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
GN   ORFNames=SRAE_1000097100 {ECO:0000313|EMBL:CEF62701.1,
GN   ECO:0000313|WBParaSite:SRAE_1000097100.1,
GN   ECO:0000313|WormBase:SRAE_1000097100};
OS   Strongyloides ratti (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF62701.1};
RN   [1] {ECO:0000313|EMBL:CEF62701.1, ECO:0000313|Proteomes:UP000035682}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC   ECO:0000313|WBParaSite:SRAE_1000097100.1}, and ED321 Heterogonic
RC   {ECO:0000313|EMBL:CEF62701.1};
RA   Martin A.A.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SRAE_1000097100.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (DEC-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517};
CC   -!- SIMILARITY: Belongs to the RdRP family.
CC       {ECO:0000256|ARBA:ARBA00005762}.
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DR   EMBL; LN609528; CEF62701.1; -; Genomic_DNA.
DR   STRING; 34506.A0A090KZ76; -.
DR   EnsemblMetazoa; SRAE_1000097100.1; SRAE_1000097100.1; WBGene00257571.
DR   WBParaSite; SRAE_1000097100.1; SRAE_1000097100.1; WBGene00257571.
DR   WormBase; SRAE_1000097100; SRP03498; WBGene00257571; -.
DR   eggNOG; KOG0988; Eukaryota.
DR   OMA; NDCISES; -.
DR   OrthoDB; 2876924at2759; -.
DR   Proteomes; UP000035682; Chromosome X.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF59; RNA-DIRECTED RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000313|EMBL:CEF62701.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000313|EMBL:CEF62701.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ   SEQUENCE   1537 AA;  180703 MW;  F34BB93853C672A2 CRC64;
     MITLENIRII FKLFLNDSSN VEKLKIILND CISESSTNLQ KIGDVAYIDN HFLDSEMHVL
     CKCNFGFLES GDFFEYLQLL KLKFKLLNIN FAIGIEKFLN NYTSFEICNT NICVQNFGWG
     TYYYPEIFYD HYNVDERWSN QYNDYNIKFK KFFNIKYQNI KLIYANFYHD IHKLNVFFSI
     PPCNKDSQFK QTENTISKLT LDYRNINRVA ISDIILSKKL KNYYIVTFNF WLFNPIKIET
     YQEISESFDE KIKKYWKWNQ VRTFCDDDNI IEVIHESSIF YLTLELSKNE MVNIIERFCT
     LISRNLEFVC WKKINLSITS LVKKPLDDKI LKKKLLKNGS FELSYLIETI LSMGLLTKVD
     LLISQEKRDT FIENVLSCYQ ENNKITLLAL ENIIKRIERM FFVKNICKMF QLIYKNESEN
     EYLVDDFIEE DIDQNIFYVR KVIVTPTRTL FKIPTAMIGN RVMRQYDPTG EKMLKVIFRT
     DNLRSTKEIG SDCILTEIIN KYLDKGIIVG GFIYNFLGAS NSQIRDGGCY FFRGSKYDMI
     SIREGLGSIK QEAIPKMMGR LGQCFTQSFL AKNAIIANDK YVKDNDYFTP VWKDSGEKEY
     CFSDGCGMIS NEMGRKIVSS FKNIFNQSST CYQFRFRGYK GVLVKYSTLD KVNQMAIDKK
     ISIKNIGRIN NDNLWTNDFS VDCVFRYSQC KFRGLLKDCQ LEIVKSSKPQ ELSLNRPLIN
     VLDQVSKLQS YECNKRICYR INELFEKHIS SIISIFLHEK NAYETLSNMS LKYFGIRKLN
     NHKLISFHKE IFFKNILKNY AIYQIKDNLK KLKIKIPTNL GRLMFGVIDE TGSLEYGQVF
     IQYSLNINSS SKKTKNKDDK KVHLGKVMIT KSPTIVAGDV RIFEAVDVNL LHDLVDVIVF
     PRDGPFPHTT EMAGSDLDGD EYSVIFDEEL FFEYNMKPFD FDVGTSTNEV VNGIKDHKDF
     DDRMKEFMLT YLTSDNVGVL ASSHLIQSDF FGINSEVCKR IAIKHNIAID FQKTGKFPQP
     LTKEWENDIP PEVPSVVAEF FDGNISKMPS YKSSRLISQL YNRLNKLETL LESSDLLLQD
     EEYTKNPLIS INGWEKYNDL AMKYYIKYST AIINLMDTFE IHDESELFCG YRINSNYNNI
     NDITNRLSYQ NINFLIQKKL TLIIYKIKTE ILETFCPLEH FYDVIPDIND YENIKRILEN
     PLSNYPKELE EFVVAGYNIL YDSTKKDIIK IYSFPWIFWD VLKKIAFINY YNNCNIISLS
     YPTFHDLLTK YIMEWYLSIN EKDKVLKKLV TEDEELKICL EYIKCYKNLN ILLTFLLSWS
     KLNNLNIKIK EDKLSDLSEE EIKNSFDINS SIGGIGKHFL NILFILSSFK FMKLDHIYGW
     EMDMECGYFL LQEHCYLIHQ AAEKTINSLV FYHAFDILPQ FKNKCNNLQD CKSYHSMYVY
     LPKNMKCHES YIFDRVKNIS GLEALKYRKE NYYFNGCKET TLWIVTPVGT YDAYLKFKQF
     IKVDVSTSFI ISEKHNFPYV LGLKLYEKII NRPVVMS
//