ID A0A090LA15_STRRB Unreviewed; 615 AA.
AC A0A090LA15;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Dbl homology (DH) domain and Pleckstrin homology domain and Pleckstrin homology-like domain-containing protein {ECO:0000313|EMBL:CEF64983.1};
GN ORFNames=SRAE_1000323600 {ECO:0000313|EMBL:CEF64983.1,
GN ECO:0000313|WBParaSite:SRAE_1000323600.1,
GN ECO:0000313|WormBase:SRAE_1000323600};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF64983.1};
RN [1] {ECO:0000313|EMBL:CEF64983.1, ECO:0000313|Proteomes:UP000035682}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000323600.1}, and ED321 Heterogonic
RC {ECO:0000313|EMBL:CEF64983.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SRAE_1000323600.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
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DR EMBL; LN609528; CEF64983.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090LA15; -.
DR STRING; 34506.A0A090LA15; -.
DR EnsemblMetazoa; SRAE_1000323600.1; SRAE_1000323600.1; WBGene00259853.
DR WBParaSite; SRAE_1000323600.1; SRAE_1000323600.1; WBGene00259853.
DR WormBase; SRAE_1000323600; SRP01615; WBGene00259853; -.
DR eggNOG; KOG3521; Eukaryota.
DR OMA; ALSRQFC; -.
DR OrthoDB; 2873655at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040181; PKHG5/7.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR PANTHER; PTHR13217:SF6; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000035682}.
FT DOMAIN 187..385
FT /note="DH"
FT /evidence="ECO:0000259|SMART:SM00325"
FT DOMAIN 441..565
FT /note="PH"
FT /evidence="ECO:0000259|SMART:SM00233"
SQ SEQUENCE 615 AA; 71219 MW; D24A6719254B2A58 CRC64;
MTESPSLTLF HHLRGNCLIK QHEDAEIMTL HPNREQLVRR DALTGLEKET DSDNDNETGT
VTDNVIIVPH LQVSTNELHL FNRAISSGGG LLADLQRATM AAQNFYEDIG SETNKRSPWV
LKRLYEWSHR AKSREIVKHV EKALQECTIS VDVDEGALKQ YIEYSWFDIF PLLPYNLNEN
EKKKFQAVWE LFHSELVFLY KQLAVLKYVY KEPLKKCQVE GCLLSIEPEL LFGNLDQIFK
ISHKFCQSFL SLLPDVCKDI NNDGKLYKEY DVVTLIVQLF ERFNKGPSTI SAYQAYCINY
KATIEYLTSI RQREERFLEF EKVCMGDRRC GRLQLEDLLI CPLQRITRLP ILLKEILKNI
TDLDEKIKIE KVIETMNESL RSIDDSVQWL HNFERIQQLQ NQVVWPSIME LDSKSFIPDF
LKTILSRQFC ENLLAHPRRK LIHEGVLTLV ESGGKLIDSY AFLFNDMFLL TKLKKANGKI
VKRGSNVGSK QEVFIVQKQP VPLDSCVFCD ADSGESQVGS SLKNAFVVIH LTRYYQVVSV
STLQASSKEE KEFWINKFQE SIENYECIQL KDMLKCTPLF SSINLRQSNL QKNSNDIYYK
ENDKSSTNIS PKKTP
//
