ID   A0A090LAZ4_STRRB        Unreviewed;       793 AA.
AC   A0A090LAZ4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00026121};
DE            EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
GN   ORFNames=SRAE_1000353100 {ECO:0000313|EMBL:CEF65278.1,
GN   ECO:0000313|WBParaSite:SRAE_1000353100.1,
GN   ECO:0000313|WormBase:SRAE_1000353100};
OS   Strongyloides ratti (Parasitic roundworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF65278.1};
RN   [1] {ECO:0000313|EMBL:CEF65278.1, ECO:0000313|Proteomes:UP000035682}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC   ECO:0000313|WBParaSite:SRAE_1000353100.1}, and ED321 Heterogonic
RC   {ECO:0000313|EMBL:CEF65278.1};
RA   Martin A.A.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SRAE_1000353100.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (DEC-2020) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC         CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC         ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00024484};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422;
CC         Evidence={ECO:0000256|ARBA:ARBA00024484};
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DR   EMBL; LN609528; CEF65278.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A090LAZ4; -.
DR   STRING; 34506.A0A090LAZ4; -.
DR   EnsemblMetazoa; SRAE_1000353100.1; SRAE_1000353100.1; WBGene00260148.
DR   WBParaSite; SRAE_1000353100.1; SRAE_1000353100.1; WBGene00260148.
DR   WormBase; SRAE_1000353100; SRP06493; WBGene00260148; -.
DR   OrthoDB; 443463at2759; -.
DR   Proteomes; UP000035682; Chromosome X.
DR   GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:UniProt.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43272:SF83; ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J; 1.
DR   PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CEF65278.1};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035682}.
FT   DOMAIN          169..597
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   793 AA;  90990 MW;  582831278C3E06C6 CRC64;
     MLKKVVKFKC LDRKNYIHIS SQVNKSMTYN HTPTAHEKIH KYHKILLRSE EITKKDVPML
     TKTCLNITKK CFALADIITH IPNIILEKEK NQIKLSRKKK SIKIEEDDFC KIFSNPKNKN
     GNIVESSFQN ITTLDKYIDY SFKKFSNQKL LGERKIEKIY EYKDNYGIKT KLIEQSSYEW
     ETYDDVYNNI QKIRSGLKKF GLKKGDKVLF YSDTRKEVLT TMLACIKEGI IVSTYSPNMS
     LKEINTVLND LNVNTIITEE AQFDKLVKIC QYSKKINQIV YFKDKHRLSK HGSNKPVKIN
     ERKLIPTKIV EKIKTILPYD EFLNYSPINK PLENVNIEKN DISFICYTSG TTSQPKGCTL
     THSNLISNIV GIKNEICFNH SNPTYVAYLP LSYIFEICGE LLCLGKGVRI GYSTTTTLTK
     KSMKVIPGTN GDLDVLKPTI VPSVPTMLNR FKRAVCEELM KKSELEQKLF TLCYNRKLNR
     KMKGLSTPIL DKTIFKITSS FLGGKVNTII CGGAPLDKDL QRFCQIISNS TFIQGYGATE
     GCAVALSSPD DITTGNVGGP TITTNFMITN WNEGGYDIKN NEGELLISGP CVINNYYKNY
     NDESFVKRNG IKWFKTGDIV KIRNDGAIMV IGRKKEFIKN ANGEFISLNK IEKTLLNCIY
     VKQICVIVNP KLDYTSAIVV INKDAIKKLG EKVELKENII NLCKNKLIRS TVVYTFEEEF
     KEILAKYEIP RKVILVSETF NQENGMLTSS GKLRRKVIEE FYKNIIELSY TPYKDELIEP
     EHLNENYIEQ KKR
//