ID A0A090MUG1_STRRB Unreviewed; 4763 AA.
AC A0A090MUG1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=E3 ubiquitin-protein ligase MYCBP2 {ECO:0000313|EMBL:CEF62183.1, ECO:0000313|WBParaSite:SRAE_1000045700.1};
GN ORFNames=SRAE_1000045700 {ECO:0000313|EMBL:CEF62183.1,
GN ECO:0000313|WBParaSite:SRAE_1000045700.1,
GN ECO:0000313|WormBase:SRAE_1000045700};
OS Strongyloides ratti (Parasitic roundworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=34506 {ECO:0000313|EMBL:CEF62183.1};
RN [1] {ECO:0000313|EMBL:CEF62183.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 Heterogonic {ECO:0000313|EMBL:CEF62183.1};
RA Aslett A.Martin.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000035682, ECO:0000313|WBParaSite:SRAE_1000045700.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ED321 {ECO:0000313|Proteomes:UP000035682,
RC ECO:0000313|WBParaSite:SRAE_1000045700.1};
RA Martin A.A.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:SRAE_1000045700.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2020) to UniProtKB.
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DR EMBL; LN609528; CEF62183.1; -; Genomic_DNA.
DR STRING; 34506.A0A090MUG1; -.
DR EnsemblMetazoa; SRAE_1000045700.1; SRAE_1000045700.1; WBGene00257053.
DR WBParaSite; SRAE_1000045700.1; SRAE_1000045700.1; WBGene00257053.
DR WormBase; SRAE_1000045700; SRP02693; WBGene00257053; -.
DR eggNOG; KOG1428; Eukaryota.
DR OrthoDB; 167377at2759; -.
DR Proteomes; UP000035682; Chromosome X.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19799; Bbox2_MYCBP2; 1.
DR CDD; cd16463; RING-H2_PHR; 1.
DR Gene3D; 2.60.120.820; PHR domain; 2.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR012983; PHR.
DR InterPro; IPR038648; PHR_sf.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45943; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR PANTHER; PTHR45943:SF1; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR Pfam; PF08005; PHR; 2.
DR Pfam; PF13540; RCC1_2; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50012; RCC1_3; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Reference proteome {ECO:0000313|Proteomes:UP000035682};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 1024..1080
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 4491..4541
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 3834..3860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4763 AA; 548955 MW; 44309FBB4E163753 CRC64;
MEYFMANFDT KKRNVKKEKN NDRDVFDKLY KLLKKTSTFQ ETSINSNGEW NNNNNKYNNS
NNTTPEYSIL TSNEMYTKIF KNLVTTVKPS NFVANSMARN CISKADVLFD IDGDEFDEEH
LMDNVNLISI LDRNIVENFI RKQKVYKNGI FDSTIEDTDT GDSSSFRSFT KPSSNNLIFS
GYQVIFSIIL DLQDQNPHMC IKALQELKRQ LECIPFRKLH YTNTGKFKNN NIFQMADTPS
NEIEVMTHSM TTKLKILRLH YNKTIADLAQ NCLLGLSIAY GSINMIFDII TSIIINERST
SERLVESGEF FKQQQIFCND DYCRVPYNFY QFVLFIQKMS LSCGWNLDRY LDLWYEDTID
NHSLLCQFNI KFKSTLKKNE NKLFSSITSD GTYLYILNNN GLFKIGTGFN ETKRGHIYMS
NVTIYGSENR NLYLFQKNKH EYLLIDNTLI TSSDFNFHKT FLLIDKGTLQ DLYHIVVKAP
AISTKTTFKD HIYFVDNSKK ENYDDSKLMF TCLDEKSNDL VIEELEINEM FEAIQKNSDN
DEKYCYSKQR YQLVYYSFVK INSSSDGNDI KKIKIPKYLF QRNIKNYYEI KDSSNKEIIG
KVLLTNCGNL WYYGDCQKFG LQNNGTEIDS EIDDDDDDEN LDDDNENLSN ERKWKRFTLS
NFFIIDNDNE KIKYISYTHD IPDSMLLTLD NGKVLLLGKS IFTLPLIKGN EFINTPTKIS
SPNNFIPSLY VKEEILLDND KNQKTSIPVR RIRFNYNKKK IVKAILKKEF CFFISETGMS
YMIPLPKLGK NNCFIKTIPD SPEVASLENI SVKDIVFGKS HGVVLDKHGK VWTLGFNDKF
QCGRDGKNND NNMTNFLFND KILNLSPRNE EHSPVRISTK NIPINSLCRN DNHYFSPDDP
PTICLICNKC SARGNRCSYA MTHSEVTYNK KSGIGLKKGD LCKCLTKSNG KVIGVCCRCG
ICKGCATNYS TYIRDAHKNP NETKKRKEID DKINYEWALQ LPINEIIIDI KAGDNHSIIL
TKDGSVYTFG SNDYGQLGIE NIENERKEKK YFYKVSFGDK KVKIDQIIAG PNISIAKTDT
GVLWFWGLIE KGCKNKNKLR IIKTKPTLLS DIINEIIDDD LKTKSDKILK NCSCSWLCMS
NNSLILQLRK NLLQSNFCDT KSNNNQLKLN NCKIIADNDY YVIMPKKVTK NQVPKYILLN
KKRQGTFTQY IPFNDNLLYP KTSISFDTIN TDIIWCYDSI DMSIKCYKKY LLKLYHHQIN
DYEDKITKLN IHENILVSEA LELLNLPEYI IPDNLSYITS INKLSDTQIG LIYLKSILSY
TIISSLSHST YENCYLKEDR SYDPENFKAC IKNENNANIF PYPNLTRYVG SKVNDKNNFK
IFKVSRFTSY SNGWSYYIPN ALTAVEAISF KSNKIINLCG IGLFGGKGNY KANVRIYKLK
GIKKIEEFGN DDEFAEILAN EEVMYETGVQ RFSSRREIDI YCVNLKKPIK LEREEWYTVV
VNMTGEPGFC GKNGKEKVRI DSGTGKEEKN GDIIITFKNS LAANNGTDIK VGQVPELFIE
IPKKDFHDND YKGETNTILT SPALSTLNVV MAETIISTMT DEMYNLNTLI TINTDGISNL
LKIIECTIDT CFGFKNDLTI YDDNIESLTN SDDIKWNKER SISLCIMGIK MLTYCMKLRY
PKEYFNYKTN GNLKHKYRYI SNPLNIDFLY TEADADIIIR FYQLLTCILK QASKNISCND
KGIYSLAKQT SETFIFCGYL FFSIKEVIMG NLIKCIIRSD MNKKISVENF NYWKLYSLFK
FIYDNKEDGH IDDLYSFMKF YEPNFCGNEF GRRSSGCNVF ENTKFGYDLG QRLITSIDTI
GYGNGTLLQR EIDVTTDDFD KASKPVNIIK FLFGFAFEKN SNKRDDDENI GENYKKIRFK
LKDITQKLLT CTFKKIIKSY SNMCQQQNIM ASLCRFSKIS GGKSWEYLNN INIKTGTSNT
NGRKGSLTGI QERSVDAISF SINNSGVILY GFSIFTGSLI MEKKEDIICM FEAELIEINE
NESKENHKIL DHVTGSVELL KSSKTQPWNG EATEDGVDAF QCHDIFFSKS ILLSPNMVYT
IKISFYFSIP LITAISLPNC CYITYFGENG TSTLQLINGT KITFFTSELC NNGTTVSRGQ
VPRILYTIRE EQSRIVDRET TKEILRNLAD IIIGNVVENT KNLIVNEKVI HENENQEIKS
NDNRNDSKIM DLNFMINIIN YSHIFSELDK RNTSIILMNL QSLIKIIGPI LMEMKCKYYS
FTNFPENKIL LSNYCRLYNG TNICTIESDH PYKRGSFVAQ FVKLHEKVDY MTLLFDPDCC
SYSTNDKLSI FLVKDNLDEK DFTNINDVVV NGNLEKNFIK ICTFSGRGKK FEKNSGNWPI
EFITLPGKKL LFIFESVSSD GKNLLTNEEE NTFCWGFKCT VTGYKNFVNE NKYFGVWNEM
NMIERLEILE KELVHIISDG CRLLMLNQNK KNLNHGMIGW CEENERGKNF YNFISKHENI
LKKGLFIDVK LHIKDIIEDG IIEDMDIDDI YDEEDDLLTR MGNGHTIERS FFNDFIEDKL
FSKGSIFLRD ILFESNENDE IGSDRYGNIM AHVDSFDNLL TEFIDLRTSE IEVHLLGKDE
DDCDTNNGNL ESIQEQVLVG QKIILRLILK DQHGKILRNV DNLKKCFIEI RESIGEIMTS
NIQYSNVIPP YISNINNYDS FEECYEGRKR AQLFSLIAAH PYKPSIAMKS KYIAMTINPI
FQDYSFEEIR WSYMTGMKKV TKEKYEFIYD NETNSRIVEW IPKKKGIYKI LAYLEDKQFL
INQNVSLNVE DVERLRIKGK KTILSFTTVT KEKSLKASWD YNPYNSGVRI RHAPSLQSYT
IGVIVHTTRF NFIDIIDNKD GIWLKVNINE DGLKNFLFNK TEIGLPDKDW QYGYVLQYSK
TLNVELIKRE DLLLNERGKS PFEVEISHIS NDIKELSTNI NNFESKQDYG SNWNNKEEHI
RSTKIIYNDK KILLTPFVFK SCRALFASYL WHTNKSKKIV NVIDRLTGGN NDNENDDFIH
ELKNLWKKII KEVLKYLENQ RYIMSSIESM RASIPDSDLL YHNNYKIYET PTKDLTTKNN
GNTIALSLSP VGNPNVPPSA LFKGTPVHVS SNMGHCELCS KYFDKPVTSH MKTSHPGCGA
PSGGKGYNSA GNYTSGWSGS CGEGAPSNCA WYILCLKCRD KYMNTDVTVV NKNSFSYGTG
AVEDISDKNS SDETDETFIE DKLEEDIIKK AIFLLKLNPY INENNNIKKN FHQTKVEDYD
DEVFKTIDQS DPEILHSILK RKSSLRKKHY SGSDLIIGNQ NTSAISDPGP SKFSINLIDD
NIEDMKKDDI KKLKVNKNLN TNKEIYKRTA RSQGNYQEYE DLGRESYSFF DTPNNSKIID
VRKIEHELFS FVFDNTPTVD LNLIKNHLKN CIKTSFLLSF TYQTFLNLIR IVSSEESIED
ILFSHIETLT IFSNNMYNYI STRQKKSYSF FKNLKILPHP GKICLLSGED LVKEVVEDFH
NFIVSLSLII KAEDEVKEVQ DMTIIEIDKF RRLKNLCLKN WNFQYTRFDK DILKELCCIV
KILGSIMSSG SPKEGKKMFL MKLKEIQDPS LSLWSSTGCG ESEVNKFINI TKKLKFDSSS
NTEILNAIME DNLETFWESS EDNKNKERYI EVEFGNLAIL KHKEKSSNTS SNTIREVPEI
VAVYIDNSID DKNFYINEVV FKAYTFNLEC CYEDNKVDGN CEFVVLKDIK LKKNFKGWVN
CYLGKIRYDL KKIRVTLRSP NQLVRLRRLI ILAGEDNVME RKIDYQERGE KNISKSFSFP
DSTLEDTSSD EEQSSTNNTP KVESDAFILF KAITGQVFEE NLNDSVDGGC CEDEKRYDDT
KVVNVKDGNG TKLRNQILDY LFSKNHLEPI KGYVSVQITK ALQKEISILK ESKKKRIPKI
KNEYDGIINK NQLNSKYKYA LNLVSIIEKL CSHNFEDIYD GPEFKSHDLL TSIEKIPVEV
KALKTDVLVL FSELLEVVSD DITTAKSVLD GIDKTIKMIN ISEKKNFVCE DVGRKVIKNM
LNIVVNGAEV GVRVKGQRSM EMFGYEDGEV IVKGDNKPGF DGIQNDNSNE NIDIEFIIKR
WLEKVITNDV DGEYGNWPIF IKDEICYNII EAINYCLGIK KSFNKEDKIL LIDECYSDTN
TNNLSSILLY NQNITNYIKL IEKPIFWMAL TSLSLLTNKQ WLDLSIFQNN ISKSTYSKSP
VEGIQDIKEL PFCENHDDYE TRASLICYDC DEMKLCKTCF KTLHLSKKKR GHSVLTLPSI
NLEDDTNNLD ESQKCSNKVS VEVHEGSIRL KIENKFLLLV NNKRLKGILE LHDIKNNVDN
DIESNIHNEN GIHRALNRLK LFDNPILYKI CRFCEGPLQT EVEKLNGVCY QSECEKYKGN
VCKKVHSNCG HFCNGIIGEK ECLPCLKCPQ IFIEFDNNIK GKINQDSDDL CSICYTDKLG
SAPCIQVTCG HIFHYHCLMT VLENKWNGPR ISFRFMKCPL CLSNLEHKDK ESKFEKIMND
YRILYEDVKK KSLMRYKYYC NIGTPKQYLI DIEDQDNDDV LVEEALQKFM YCLCYKCGKA
YYGGDVNCHQ VLLQEDDGNQ HKIIFKPEEL ICGGCSNVAG GGSCTKHGTE YIEYKCRFCC
SVAVYFCFGT THFCQICHSD FQRLMILKGD ELPNCPVGPK ATPIVIEGEI KDKKDVCPLK
INHPDTGIEF SLGCGACRNI REF
//
