ID A0A090N389_OSTTA Unreviewed; 355 AA.
AC A0A090N389; A0A1Y5ILR1; A0A454Y337;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase {ECO:0000313|EMBL:CEF97698.1};
DE SubName: Full=Flavonol reductase {ECO:0000313|EMBL:OUS49607.1};
GN ORFNames=BE221DRAFT_188915 {ECO:0000313|EMBL:OUS49607.1},
GN OT_ostta04g04220 {ECO:0000313|EMBL:CEF97698.1};
OS Ostreococcus tauri.
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Bathycoccaceae; Ostreococcus.
OX NCBI_TaxID=70448 {ECO:0000313|EMBL:CEF97698.1, ECO:0000313|Proteomes:UP000009170};
RN [1] {ECO:0000313|Proteomes:UP000009170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OTTH0595 {ECO:0000313|Proteomes:UP000009170};
RX PubMed=16868079; DOI=10.1073/pnas.0604795103;
RA Derelle E., Ferraz C., Rombauts S., Rouze P., Worden A.Z., Robbens S.,
RA Partensky F., Degroeve S., Echeynie S., Cooke R., Saeys Y., Wuyts J.,
RA Jabbari K., Bowler C., Panaud O., Piegu B., Ball S.G., Ral J.-P.,
RA Bouget F.-Y., Piganeau G., De Baets B., Picard A., Delseny M., Demaille J.,
RA Van de Peer Y., Moreau H.;
RT "Genome analysis of the smallest free-living eukaryote Ostreococcus tauri
RT unveils many unique features.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11647-11652(2006).
RN [2] {ECO:0000313|EMBL:CEF97698.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RCC4221 {ECO:0000313|EMBL:CEF97698.1};
RA Derelle E., Ferraz C., Rombauts S., Rouze P., Worden A.Z., Robbens S.,
RA Partensky F., Degroeve S., Echeynie S., Cooke R., Saeys Y., Wuyts J.,
RA Jabbari K., Bowler C., Panaud O., Piegu B., Ball S., Ral J.P., Bouget F.Y.,
RA Piganeau G., De Baets B., Picard A., Delseny M., Demaille J.,
RA Van de Peer Y., Moreau H.;
RT "Genome analysis of the smallest free-living eukaryote Ostreococcus tauri
RT unveils many unique features.";
RL Proc. Natl. Acad. Sci. U.S.A. 131:11647-11652(2006).
RN [3] {ECO:0000313|EMBL:CEF97698.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RCC4221 {ECO:0000313|EMBL:CEF97698.1};
RX PubMed=25494611; DOI=10.1186/1471-2164-15-1103;
RA Blanc-Mathieu R., Verhelst B., Derelle E., Rombauts S., Bouget F.Y.,
RA Carre I., Chateau A., Eyre-Walker A., Grimsley N., Moreau H., Piegu B.,
RA Rivals E., Schackwitz W., Van de Peer Y., Piganeau G.;
RT "An improved genome of the model marine alga Ostreococcus tauri unfolds by
RT assessing Illumina de novo assemblies.";
RL BMC Genomics 15:1103-1103(2014).
RN [4] {ECO:0000313|EMBL:OUS49607.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC 1115 {ECO:0000313|EMBL:OUS49607.1};
RG DOE Joint Genome Institute;
RA Blanc-Mathieu R., Krasovec M., Hebrard M., Yau S., Desgranges E.,
RA Martin J., Schackwitz W., Kuo A., Salin G., Donnadieu C., Desdevises Y.,
RA Sanchez-Ferandin S., Moreau H., Rivals E., Grigoriev I.V., Grimsley N.,
RA Eyre-Walker A., Piganeau G.;
RT "Population genomics of picophytoplankton unveils novel chromosome
RT hypervariability.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAID01000004; CEF97698.1; -; Genomic_DNA.
DR EMBL; KZ155771; OUS49607.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A090N389; -.
DR STRING; 70448.A0A090N389; -.
DR InParanoid; A0A090N389; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000009170; Chromosome 4.
DR Proteomes; UP000195557; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000009170}.
FT DOMAIN 19..270
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 355 AA; 39880 MW; 00E6D516454D65DA CRC64;
MARASSSSAA LPPVPKNCVV TGGSGFVGRR LVEMLVERGA ERVVAFDVAP RPADAKDDSR
IIWQRGDLTS PSDVDEAIKG ADCVWHIAAL VGPYHARDMY DKVNRVGTLN VIEACKRHGV
SKCVMSSSPS TRFDGGDING KRESELCIPK TFLQPYAESK AMGERAMMEA CDGKTFFTIA
VAPHQVYGPR DMLFLHNFLI NAKRLRIFGS GENLISMCYV DNYCHGLILA ERALYPDSPA
LRKFYICTDG EPVKLWDFLD RAFVELGYPS LRAKFRLPGW SFMMPLAHVC DAVGYVLGRK
FKLTPFSVRM LLINRWFNID AARQDLGYEP IVDPEEAWSR TKSWFETEWK PKYGK
//
