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Database: UniProt
Entry: A0A090V3S5_ESCVU
LinkDB: A0A090V3S5_ESCVU
Original site: A0A090V3S5_ESCVU 
ID   A0A090V3S5_ESCVU        Unreviewed;       487 AA.
AC   A0A090V3S5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   05-JUL-2017, entry version 23.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:GAL59525.1};
GN   ORFNames=EV102420_20_00350 {ECO:0000313|EMBL:GAL59525.1};
OS   Escherichia vulneris NBRC 102420.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=1115515 {ECO:0000313|EMBL:GAL59525.1, ECO:0000313|Proteomes:UP000029462};
RN   [1] {ECO:0000313|EMBL:GAL59525.1, ECO:0000313|Proteomes:UP000029462}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 102420 {ECO:0000313|EMBL:GAL59525.1,
RC   ECO:0000313|Proteomes:UP000029462};
RA   Yoshida Y., Hosoyama A., Tsuchikane K., Ohji S., Ichikawa N.,
RA   Kimura A., Yamazoe A., Ezaki T., Fujita N.;
RT   "Whole genome shotgun sequence of Escherichia vulneris NBRC 102420.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAL59525.1}.
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DR   EMBL; BBMZ01000020; GAL59525.1; -; Genomic_DNA.
DR   EnsemblBacteria; GAL59525; GAL59525; EV102420_20_00350.
DR   Proteomes; UP000029462; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029462};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029462}.
FT   DOMAIN      184    386       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      395    464       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     192    199       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   487 AA;  54938 MW;  278CCF1FB2772ED1 CRC64;
     MSTIINFSFR LLLSTFVRVE SAVSLSLWQQ CLARLQDELP ATEFSMWIRP LQAELSDNTL
     ALYAPNRFVL DWVRDKYLNN INGLLNEFCG SDTPQLRFEV GTRPVAHTLK EPASVAAPAQ
     VAAVQMPRVA PASRSSWDNV PAPAEPTYRS NVNVKHTFDN FVEGKSNQLA RAAARQVADN
     PGGAYNPLFL YGGTGLGKTH LLHAVGNGIV ARKPNAKVVY MHSERFVQDM VKALQNNAIE
     EFKRYYRSVD ALLIDDIQFF ANKERSQEEF FHTFNALLEG NQQIILTSDR YPKEINGVED
     RLKSRFGWGL TVAIEPPELE TRVAILMKKA DENDIRLPGE VAFFIAKRLR SNVRELEGAL
     NRVIANANFT GRAITIDFVR EALRDLLALQ EKLVTIDNIQ KTVAEYYKIK VADLLSKRRS
     RSVARPRQMA MALAKELTNH SLPEIGDAFG GRDHTTVLHA CRKIEQLREE SHDIKEDFSN
     LIRTLSS
//
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