ID A0A091CTB0_FUKDA Unreviewed; 622 AA.
AC A0A091CTB0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Histone-lysine N-methyltransferase PRDM9 {ECO:0000313|EMBL:KFO21642.1};
GN ORFNames=H920_16972 {ECO:0000313|EMBL:KFO21642.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21642.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO21642.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO21642.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KN124332; KFO21642.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091CTB0; -.
DR STRING; 885580.ENSFDAP00000009205; -.
DR eggNOG; KOG1721; Eukaryota.
DR eggNOG; KOG2461; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR003655; aKRAB.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR048414; PDRM9-like_Znf-C2H2.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019041; SSXRD_motif.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14112:SF1; KRAB-RELATED DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14112; SYNOVIAL SARCOMA, X MEMBER; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF09514; SSXRD; 1.
DR Pfam; PF21225; zf-C2H2_5; 1.
DR SMART; SM00349; KRAB; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50806; KRAB_RELATED; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KFO21642.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KFO21642.1};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 27..90
FT /note="KRAB-related"
FT /evidence="ECO:0000259|PROSITE:PS50806"
FT DOMAIN 214..308
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 338..361
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 69280 MW; 27A253ECDC0BB290 CRC64;
MSAQSSPEHR PEEEKEEDSA GAGPPPKVKD AFKDISRYFS KEEWAKMGEF EKKRYRNVKN
NYSTMLSIGL KARRPAFMCR RRRTSTTNPP VGDSDDSDEE WTPRQPVKPP WVALRVEQSK
HRKGLPRALL NSEPRPKGPP GTASLQDTGG PDRTQTPASC PGEARDSGQH SRRKLEARGK
RVAPKMYSLR ERKCHTYQEV SEPQDDDYLY CEKCKNYFLE SCPAHGPPAF VKDSAWKLSP
PDTQITKGRH CYEYVDGKDT SRANWMRYVN CARDEEEQNL VAFQYHRQIF YRTCQAIRPG
SELFVWYGNE YGEELGIKWG SKWKKQRAAG TGPKAEVHPC PSCSLAFSSQ RFLSQHVKRS
HPSQICPGTP VRKNPKTESP HLEDHRQESD PRSRRKDEGG GPEPLMSTSS CGKFWNVTRR
RPLLGSALCP LGSPESFQSL RFCTDRGEEG QRVIVCVTGP GYVGGGDTSA SGVSSPPQGP
EASGFPTGGS HDTMTYCLNS KSPVSRTQSR LLHFLNKAAP CITGPVVLKW AVTQVWFQNR
RAKCRKQENQ MHKGVILGTA SHLDACRVAP YVNMGALRMP FQQCTLPAVG AVLGALCSGP
EPGKQAFALR PPHTTVSVTA GT
//
