ID A0A091CVR5_FUKDA Unreviewed; 1084 AA.
AC A0A091CVR5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Ubiquitin-protein ligase E3B {ECO:0000313|EMBL:KFO23729.1};
GN ORFNames=H920_14933 {ECO:0000313|EMBL:KFO23729.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO23729.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO23729.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO23729.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN123755; KFO23729.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091CVR5; -.
DR STRING; 885580.ENSFDAP00000009988; -.
DR eggNOG; KOG4427; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR45700:SF3; UBIQUITIN-PROTEIN LIGASE E3B; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:KFO23729.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 718..1084
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 1052
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1084 AA; 124519 MW; 89518A54E1C8D9FB CRC64;
MFTVSQTSRA WFIDRTRQAR EERLVQKERE RAAVDIQAHV RSFLCRHRLH RDIRREIDEF
LKDDDSGSSK RSALCIFKTA RKLLFLFKIK EDNERFEKLC RCILSSMDAE NEPKVWYVSL
ALSKDLTLLW IKQIKSILWY CCEFLEQLKP EILQDSKLIT LYLTMLVTFT DASTWKILRG
KGESLRPAMN HICANIMGHL NQHGFYSVLR VLLTRGLARS RPCLSKGTLT AAFSLALRPV
IAAQFSDNLI RPFLIHILSV PALVTHLSTV TPEPVATVGN AYVSSAKKQR LTVLESHDTL
RKFILFLRDA DRCHDICENL EGCHTLCLMG NILQLGSLSP QVLEEETDGF VSLLTRMLCY
CQKYVSQKKS NLTHWHPVLG WFSQSVDYGL NESMYLITKQ LQFLWGVSLI RTFFSDILSK
KLLEHQEPAP AQPASPQNVL PVKSLLRRAF QKSASVRNIL RPVGGKRVDS AEVQKVCSIC
VLYQTSLTTL TQIRLQILTG LTYLDDLLPK LWAFICELGP HGGLKLFLEC LNNDTEESKQ
LLAMLMLFCD CSRHLITILD DIEVYEEQIS FKLEELVTIS SFLNSFVFKM IWDGIVENAK
GETLELFQSV HGWLMVLYER DCRRRFAPED HWLRKDLKPS VLFQELDKDR KRAQLILQYI
PHVIPHKNRV LLFRNMVTKE KEKLGLVETS SASPHVTHIT IRRSRMLEDG YEQLRQLSQH
AMKGVIRVKF VNDLGVDEAG IDQDGVFKEF LEEMIKRVFD PALNLFKTTS GDERLYPSPT
SYIHENYLQL FEFVGKMLGK AVYEGIVVDV PFASFFLSQL LGHHHSIFYS SVDELPSLDS
EFYKNLTSIK RYDGDIADLG LTLSYDEDVM GQLVCHELIP GGKTIPVTNE NKISYIHLMA
HFRMHTQIKN QTAALISGFR SIIKPEWIRM FSTPELQRLI SGDNAEIDLD DLKKHTIYYG
GFHGSHRVII WLWDILASDF TPEERAMFLK FVTSCSRPPL LGFAYLKPPF SIRCVEVSDD
QDTGDTLGSV LRGFFTIRKR EPGGRLPTSS TCFNLLKLPN YSKKSVLREK LRYAISMNTG
FELS
//
