GenomeNet

Database: UniProt
Entry: A0A091CX45_FUKDA
LinkDB: A0A091CX45_FUKDA
Original site: A0A091CX45_FUKDA 
ID   A0A091CX45_FUKDA        Unreviewed;      1811 AA.
AC   A0A091CX45;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=H920_16156 {ECO:0000313|EMBL:KFO22460.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO22460.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO22460.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO22460.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; KN124048; KFO22460.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR028803; SCN9A.
DR   PANTHER; PTHR10037:SF221; PTHR10037:SF221; 4.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KFO22460.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    212    232       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    283    310       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    641    668       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    680    703       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    715    739       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    760    788       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    850    873       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1097   1115       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1136   1152       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1164   1184       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1213   1239       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1339   1357       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1369   1387       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1399   1419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1456   1484       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1560   1583       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      170    316       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      389    599       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      650    878       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      887   1091       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1095   1332       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1338   1593       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      307    352       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1811 AA;  204823 MW;  0E3CA3416EEE9D0E CRC64;
     MATLPPPGPQ SFVHFTKQSL AHIEQRITER KAQEPKEEKK DDDEEGPKPS RDLEAGKQLP
     FIYGDIPPGM VSEALEDLDP YYADKKTFIV LNRGKAIFRF NATPALYILS PFSPLRRISI
     KILVHSYPFQ SAYLKCMLIM CTILTNCIFM TMSNPPEWTK NVEYVTEFVD LGNVSALRTF
     RVLRALKTIS VIPGLKTIVG ALIQSVKKLS DVMILTVFCL SVFALIGLQL FMGNLKHKCL
     HKDLVTNETA INILKNFESE EELKSKNAPV VVNRTLRAAG KTYMIFFVVV IFLGSFYLIN
     LILAVVAMAY EEQNQANIEE AKQKELEFQQ MLDQLKKEQE EAEAIAAAAA EYTSIGRSQI
     MGLSESSSET SKLSSKSAKE RRNRRKKKNQ KKLSTGGEKR DDEKLPKSES DGSIQKKSFF
     LGVEGRREAR EKRLSTPNQS PLSIRGSLFS PRRSSRTSLF SFKGRGKDIG SETEFADDEH
     SIFGDNESRR GSLFLPPRFR ERRSSNISQA SRSPPMLPVN GKMHSAVDCN GVVSLVDGPS
     ALMLPNGQLL PEVIIDKATS DDSGTTIQIR KKRCSSSHFL SEDLLNDPHV RQRAMSRASI
     LTNTVEELEE SRQKCPPWWY RFAHTFLIWN CSPYWIKFKK IIYFIVMDPF VDLAITICIV
     LNTLFMAMEH YPMTLEFKNV LAVGNLVFTG IFAAEMVLKL IAMDPYEYFQ VGWNIFDSII
     VTLSLVELFL SDVEGLSVLR SFRLLRVFKL AKSWPTLNML IKIIGNSVGA LGNLTLVLAI
     IVFIFAVVGM QLFGKSYKEC VCKINEDCTL PRWHMHDFFH SFLIVFRVLC GEWIETMWDC
     MEVAGQTMCL IVYMMVMVIG NLVVLNLFLA LLLSSFSSDN LTAIEEDPDA NNLQIAVARI
     KKGIDYVKQT AREFILKAFS KKPKLSQEIR PAEDLNGKKE NCISNRTLAE MSKDSNFHKE
     NEKSSGCGSS MGRNLMEESD YHSFIHNPSL TVTVPIAPGE SDLENMNTEE LSSDSDSDYS
     KERLNRTSSS ECSTVDNPVP GDEEAESEPT NSDEPEACFT DGCVRRFPCC QVSIESGRGK
     VWWNIRKTCY RIVEHSWFES FIVLMILLSS GALAFEDIYI EKKKTIKIIL EYADKIFTYI
     FILEMLLKWV AYGYKTYFTN AWCWLDFLIV DVSLVTLVAS TLGYSDLGPI KSLRTLRALR
     PLRALSRFEG MRVVVNALIG AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK FYECVNTTDG
     LRFLESQVQN RSECFALMNG TTDVRWKNLK VNFDNVGLGY LSLLQVATFK GWMDIMYAAV
     DSVGNKFQGC IFDLVTNQAF DITIMVLICL NMVTMMVEKE GQSVEMENVL YWINVVFIIL
     FTGECVLKLI SLRHYYFTVG WNIFDFVVVI LSIVGMFLAG LIEKYFVSPT LFRVIRLARI
     GRILRLIKGA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI YAIFGMSNFA YVKREVGIDD
     MFNFETFGNS MICLFQITTS AGWDGLLAPI LNSGPPDCDP EKDHPGSSVK GDCGNPSVGI
     FYFVSYIIIS FLVVVNMYIA VILENFSVAT EESTEPLSED DFEMFYEVWE KFDPDATQFI
     EFAKLSDFAA ALDPPLLIAK PNKVQLIAMD LPMVSGDRIH CLDILFAFTK RVLGEGGEMD
     SLRSQMEERF MSANPSKVSY EPITTTLKRK QEDVSATVIQ RAYRHYRLRK NVKNISSIYI
     KDGDRDDDLP NKEEIVFDNV NGNSSPEKTD ATPSTISPPS YDSVTKPEQE KYETDKTEKE
     DKGKDGKDSK K
//
DBGET integrated database retrieval system