ID A0A091CYR0_FUKDA Unreviewed; 1363 AA.
AC A0A091CYR0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Nuclear receptor coactivator 1 {ECO:0000313|EMBL:KFO23383.1};
GN ORFNames=H920_15284 {ECO:0000313|EMBL:KFO23383.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO23383.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO23383.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO23383.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR EMBL; KN123775; KFO23383.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000009389; -.
DR eggNOG; KOG3561; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:InterPro.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:UniProt.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd18948; bHLH-PAS_NCoA1_SRC1; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR028819; NCOA1_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF1; NUCLEAR RECEPTOR COACTIVATOR 1; 1.
DR Pfam; PF07469; DUF1518; 2.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 3.
DR SMART; SM01151; DUF1518; 2.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000313|EMBL:KFO23383.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 23..80
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 109..180
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1327..1363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1099
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1344..1363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1363 AA; 147689 MW; A74490A58275DEBD CRC64;
MSGLGDSSSD PANPDSHKRK GSPCDTLASS TEKRRREQEN KYLEELAELL SANISDIDSL
SVKPDKCKIL KKTVDQIQLM KRMEQEKSTT DDDVQKSDIS SSSQGVIEKE SLGPLLLEAL
DGFFFVVNCE GRIVFVSENV TSYLGYNQEE LMNTSVYSIL HVGDHAEFVK NLLPKSLVNG
VPWPQEATRR NSHTFNCRML IHPPDEPGTE NQEACQRYEV MQCFTVSQPK SIQEDGEVMT
RGTASSPSYR FILNDGTMLS AHTKCKLCYP QSPDMQPFIM GIHIIDREHS GLSPQDDTNS
GMSIPRVNPS VNPSISPAHG VARSSTLPPS NSNMVSTRVN RQQSSDLHSS SSHTNSSNSQ
GSFGCSPGNQ IVANVALSQG QASSQSSNPS LSLNNSAMEG TGISLTQFMS PRRQVTSGLA
TRARMPNNSF PPNIPTLNSP VGMTSSGCNN SNRSYSNIPV TSLQGMNEGP NNSVGFSANS
PVLRQMSSQN SPSRLNLQPA KSESKDNKEI ASILNEMIQS DNSSSDGKPL DSGLLHNNDR
VSDGDSKYAQ TSHKLVQLLT TTAEQQLRHA DLDTSCKDVL SCTGTSNSAS ANSSGGTCPS
SHSSLTERHK ILHRLLQEGS PSDITTLSVE PDKKDSASTS VSATGQAQGN SNIKLELDAS
KKKETKDHQL LRYLLDKDEK DLRSTPNLSL DDVKVKVEKK EQMDPCNTNP TPVTKPAPEE
IKLESQSQFT ADLDQFDQLL PTLEKAAQLP GLCETDRMDG AATSVTIKSE ILPASLQSTT
ARPTARLNRL PELELEAIDN QFGHPGTGDQ IPWANNAVTA VNQTKPEDQC ISSQLDELLC
PPTTVEGRND EKALLEQLVS FLSGKDETEL AELDRALGID KLVQGGGLDV LSERFPPPQA
TPPLMMEERP NLYPQPYSSP SPTANLPSPF QGMVRQKPSL GTMPVQVTPP RGAFSPGIGM
QPRQTLNRPP AAPNQLRLQL QQRLQGQQQL IHQNRQAILN QFAAATPVGI NMRSGMQQQI
TPQPPLNAQM LAQRQRELYS QQHRQRQLIQ QQRAMLMRQQ SFGNNLPPSS GLPVQMGNPR
LPQGAPQQFP YPPNYGTNPG TPPASTSPFS QLAANPEASL ATRNSMVSRG MAGNMGGQFG
TAINPQMQQN VFQYPGSGMV PQNEANFAPS LSPGSSMVPM PIPPPQSSLL QQTPPASGYQ
SPDMKAWQQG AMGSNNVFGQ AVQNQPTPAQ PGVYNNMSIT VSMAGGNTSV QNMNPMMGQM
QMSSLQMPGM NPVCPDQIND PALRHTGLYC NQLSSTDLLK TEADGTQQVQ QVQVFADVQC
TVNLVGGDPY LNQPGPLGSQ KPTPGPQTPQ AQQKSLLQQL LTE
//
