ID   A0A091D0A6_FUKDA        Unreviewed;       799 AA.
AC   A0A091D0A6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=RasGAP-activating-like protein 1 {ECO:0000313|EMBL:KFO23585.1};
GN   ORFNames=H920_15158 {ECO:0000313|EMBL:KFO23585.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO23585.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO23585.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO23585.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN123762; KFO23585.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091D0A6; -.
DR   STRING; 885580.ENSFDAP00000013543; -.
DR   eggNOG; KOG2059; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001562; Znf_Btk_motif.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF3; RASGAP-ACTIVATING-LIKE PROTEIN 1; 1.
DR   Pfam; PF00779; BTK; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00107; BTK; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS51113; ZF_BTK; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00432}.
FT   DOMAIN          1..97
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          108..223
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          293..503
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          558..665
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   799 AA;  89146 MW;  86939BC2C44FA485 CRC64;
     MEPHFHTRTL RPHGSGSSDP YCLVKVDDEV VARTATVWRS LSPFWGEEYT VHLPLDFHHL
     AFYVLDEDTV GHDDVIGKIS LSKEAIMADP RGIDSWINLS RVNPDAEVQG EVRLAVRLLQ
     DVHGRCLRCH LLQARDLAPR DMSGTSDPFA RIFWGSQSLE SSIIKKTRFP HWDEVLELRE
     VPGSPTPLRV ELWDWDMVGK NDFLGMVEFP AQILQHKPPD GWFRLQPFPS AEEDCGGSLG
     ALRLKVRLAE DRVLPSQYYR PLMALLLESV RGSPEEDTAS PLAVLEELTS GDCRQDLATK
     LVKLFLGQGL AGPFLDYLTR REVARTTDPN TLFRSNSLAS KAVEQFMKLV GMRYLHEVLK
     PVLNRVFEEK KYMELDPGKM DLGRARRISF KGMPSEEQVR ETSLGLLTGY LGLIVDAVVS
     SAGRCPPTMR LAFRRLRQCV EEHFPATEHE DVKYLAVSGF LFLRFFAPAI LTPKLFDLRD
     QHADPQTSRS LLLLAKAVQS IGNLGQQLGQ GKELWMAPLH PFLLQSVARV RDFLDQLVDV
     QEDEEAGGPA RALVPPSVTV REGFLLKRKE ESGGLAARFA FKKRYFRLSG ETLSYAKGPE
     GQVPTSIPVS HICAVERVDE GAFQLPHVMQ VVTQDSAGML HTTYLQCKNV NDLNQWLSAL
     RKASAPNQDK LAACHPGAFR GGRWTCCLQA ERSAAGCSRT HAAVTLGDWS DPLDPDAEAQ
     MVYRQLLLGR DQLRLTVLEE PNPDAASEAD TGQGPCSEAL ARQRAAAAHL LEVLEDLDHA
     HEKFQWQGQG KVALGCRGP
//