ID A0A091D171_FUKDA Unreviewed; 1261 AA.
AC A0A091D171;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Papilin {ECO:0000313|EMBL:KFO24233.1};
GN ORFNames=H920_14363 {ECO:0000313|EMBL:KFO24233.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO24233.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO24233.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO24233.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN123629; KFO24233.1; -; Genomic_DNA.
DR RefSeq; XP_010643734.1; XM_010645432.2.
DR AlphaFoldDB; A0A091D171; -.
DR STRING; 885580.ENSFDAP00000019224; -.
DR Ensembl; ENSFDAT00000012935; ENSFDAP00000019224; ENSFDAG00000009295.
DR GeneID; 104877102; -.
DR CTD; 89932; -.
DR eggNOG; KOG3510; Eukaryota.
DR eggNOG; KOG4597; Eukaryota.
DR OMA; KLDSGWF; -.
DR OrthoDB; 2910701at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd22635; Kunitz_papilin; 1.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF179; PAPILIN; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF16626; Papilin_u7; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 4.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00406; IGv; 3.
DR SMART; SM00131; KU; 1.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1261
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001871229"
FT DOMAIN 740..790
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT DOMAIN 889..981
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1019..1106
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1113..1198
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1212..1251
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 546..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..601
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..74
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 42..79
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 53..64
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 1261 AA; 136238 MW; F7544B28C0C49D5A CRC64;
MRLLLLLPLL VVWAPGSSAP EARQQSDTWG PWGEWSPCSR TCGGGISFRE RPCYSQRKDG
GPSCVGPARS HRICRTESCP EGARDFRAEQ CAELDGALFH GRRYRWLPYY GAPNKCELNC
IPEGENFYYK HREAVLDGTP CDPSRRDVCV DGHCRVVGCD HELDSSKEED KCLQCGGDGT
TCYPVTGTFA ANDLSRGYNR IFIIPAGATS IRIEEATASR NFLAVRSVRG EYYLNGHWAI
SEAKALPVAS TILHYERGSE GDLAPERLQA RGPTSEPLII ELISQEANPG VHYEYYLPLR
SPESSQGFSW SHTSWGDCSA ECGGGHQSRL VFCTSDKEVY PSHMCQRHPR PADHRSCNSH
PCPQTKRWKI GPWAPCSASC GGGVQSRSVY CVSSDGAGGQ EAAEEAECAG LPGKPPSTQA
CNLQRCAAWS AGPWGECSVT CGAGIRRRSV TCRGDQGSLF PASACSLEDR PPIMETCVQA
ACPLLSDQAW RVSAWGLCSK SCSSGIRKRQ VICAIGPPSH CRNMQQSKPR DVEHCNMQPC
HLPQEVPSVQ DSHAHPRGPW MPLGPRKTLA SDSRDQRPWV PNRSRGLPDS PPSPPGQTPS
LQQPPRSGLR AHNCRHSTYG CCPDGHTASL GPQGQGCPRT EAWCQQSRYG CCPDGVSAAK
GPQQAGCGRS YGSDNAGRRP GSKEVPSTAS KVHRPQAQQN EPTECRGSQF GCCYDNMASA
AGPLGEGCTG QPSSAYPVRC LLPSAHGSCA DWAPRWYFIP SVGLCNRFWY GGCHGNANNF
ASEQECMDSC RGAQHGPHLP EPAATGLGTH TDGRGSGARG RQETNRHRPG DTDQRLSPSS
GGPWRREQEP LPGETHPTRT FGEWPGGQEI GHRTPGLGRD SRWPVPPSPS SSYRISLAGS
GPSEVQAAMG QQIQLFCPAD VSRESQAGWQ KDGQPISSDR HQLQSDGSLV IGPLRAEDAG
VYSCGGNRPG RDPQRIQLRV TGGDLAVPSE SEPRHFPRTR DPARGQGEGT GVPSSQPRPA
TRLRLDHTQP GVVDTNPGQQ VRLSCRAEGF PSPVIQWQRD GQPVASPRHQ VQPDGSLVIS
RVAVEDGGFY ACVAFNGQYQ DQRWVQLRVL GELTITGLPP SMTVSEGDTA RLSCVVGDAS
ANIRWSRNGV PVQADGHRVH QSPDGTLLIH NLRAQDEGSY TCSAYRGSQA VSRSTEVKVA
VPAATTQPRE AGGGECIDQP ELANCDLILQ AQLCGNEYYS SFCCASCARF QPRARPAQQQ
G
//
