ID A0A091D7X2_FUKDA Unreviewed; 1053 AA.
AC A0A091D7X2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Protein transport protein Sec24A {ECO:0000313|EMBL:KFO26588.1};
GN ORFNames=H920_11987 {ECO:0000313|EMBL:KFO26588.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO26588.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO26588.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO26588.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Cytoplasmic vesicle, COPII-coated
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR EMBL; KN123144; KFO26588.1; -; Genomic_DNA.
DR RefSeq; XP_019065428.1; XM_019209883.1.
DR AlphaFoldDB; A0A091D7X2; -.
DR STRING; 885580.ENSFDAP00000007812; -.
DR GeneID; 104873242; -.
DR CTD; 10802; -.
DR eggNOG; KOG1985; Eukaryota.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803:SF1; PROTEIN TRANSPORT PROTEIN SEC24A; 1.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 388..424
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 461..699
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 704..788
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 799..899
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 925..998
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 30..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..112
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..181
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 115565 MW; 5B08EA91499F8D83 CRC64;
MSSHAPVNQG YNSQLPGSYP HLLPAKTLNL ASGQSSYHGS QGSGQTLHKP PVASLSVAPS
PYSGPVPRMP PPASQSPAAA PRLSGGFPPG ASPLPPVNWQ HSSPPMAPQT NHCPPEPSQL
AVLGNTNLSV HHQYVSSGDP SLQNNYVTSG SALSLRNPPL PTTFQPGAPP GPPPAGGPPL
VRAPVPQNVS LRAAPQPSFN SAANQEGITS NTNNGSMMVH GSYDEIEGGG FLATPQFATK
NPQMSRGVGY AYPSLPPGYQ NTAPPTSATG MPSSLNYRSG PQAFPQTPLG ANHLTASMSG
LSLHPEGLQV VNLLQERKML PTTPLQPPAP NLHEDIQKLN CNPELFRCTL TSIPQTQALL
NKAKLPLGLL LHPFKDLVQL PVVTSSTIVR CRSCRTYINP FVSFLDQRRW KCNLCYRVND
VPEEFMYNPL TRVYGEPHRR PEVQNATIEF MAPSEYMLRP PQPPVYLFVF DVSHNAFETG
YLNSVCQSLL DNLDLLPGNT RTKIGFITFD STIHFYSLQE GLSQPQMLII SDIDDIFIPM
PENLLVNLNE SKELVQGLLK TLPQMFNKSL ETQSALGPAL QAAFKLMSPT GGRMSVFQTQ
LPTLGVGALK PREEPNQRSS AKEIHLTPST DFYKKLALDC SGQQVAVDLF LLSGQYSDLA
SLGCISRYSA GSVYYYPSYH HQHNPVQVQK LQKELQRYLT RKIGFEAVMR IRCTKGLSIH
TFHGNFFVRS TDLLSLPNVN PDAGYAVQMS VEETLTDTQL VSFQSALLYT SSKGERRIRV
HTLCLPVVST LNEIFLGADV QAISGLLANM AVDRSMTASL SDARDALVNA VIDSLSAYRS
SVLSNQQPGL VVPFSLRLFP LFVLALLKQK SFQTGTNTRL DERIFAMCQV KNQPLVYLML
TTHPSLYRVD TLSDEGALNI NDRTIPQPPV LQLSVENLSR DGAFLMDAGS VLMLWIGKNC
AQHFLSQVLG VQNYASIPQA MTDLPELDTP ESSRTLAFIS WLREQRPFFP ILHIIRDESP
MKANFLQNMV EDRTESALSY YEFLLHIQQQ VNK
//
