ID A0A091D900_FUKDA Unreviewed; 913 AA.
AC A0A091D900;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Protein FAM13B {ECO:0000313|EMBL:KFO19301.1};
GN ORFNames=H920_19232 {ECO:0000313|EMBL:KFO19301.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO19301.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO19301.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO19301.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the FAM13 family.
CC {ECO:0000256|ARBA:ARBA00007549}.
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DR EMBL; KN125101; KFO19301.1; -; Genomic_DNA.
DR RefSeq; XP_010612055.1; XM_010613753.2.
DR AlphaFoldDB; A0A091D900; -.
DR STRING; 885580.ENSFDAP00000009834; -.
DR eggNOG; KOG4270; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04393; RhoGAP_FAM13A1a; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR039102; FAM13.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15904; FAM13; 1.
DR PANTHER; PTHR15904:SF16; PROTEIN FAM13B; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 23..212
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 220..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 913 AA; 104087 MW; 2036F317936AACB4 CRC64;
MRKSSSPSLS NCNSVLANKI FGIPLDELQQ GGHPDNEVPF IVRHVVDYIE EHGGLEQQGL
FQVNGNAETV EWLRQRYDSG EEVDLVKEAD VPSAISLLRF FLQELPEPVI PASLHIHLMH
LSQDYNNEDE FGRKLRFLLQ QLPPVNYSLL KFLCRFLANV ASHHDEIWSA NSLAAVFGPD
VFHIYTDVED MKEQEIVSRI MAGLLENYYE FFENEEEDFS SNDLSSITEQ VNDLSEEEDE
KLEHIEELPE EGAEKSNDMP EVVQLRMTEN ILESSNVTAS TSAHISPTSI LPASADVLER
TVRAAVEQHL FDLQSSINHD LKNLQQQSLV CSNEAGSINC DEQRPNNQVD IADGIVNASD
SNKECSEPVA GANLDNEVMQ QDFVFEDEEN QSAGVLLEPC SDHGDSEDGC PERKEYLVFD
SDKLSHLFLE SSSKICDLNA NTESEVPRGQ SVGVQGEAAC IQIPQLDLKN ASDGDKWEEP
FPAFKSWQED SESGEAQLSP QAGRMNHHPL EEDCPPVLSH RSLDFGQSQR FLHDPETLSS
SSKALSYARI RRSSFSSKDE KREDRTPYQL VKKLQKKIRQ FEEQFEREKN SKPSYSDIAA
NPKVLKWMTE LTKLRKQIKD AKPKSSDGEF VPQTRPRSNT LPKSFGSSLD HEGETSEDES
RTIQKEKKLS KEATLEFILK KLKEKRVERC LPEDIKKMTK DHLVEEKTSL QKSLLYYESQ
HGRPVTREER HIVKPLYDRY RLVKQMLTRA SITPLLGSPS TKRRVQMLQP IIEGETAHFF
EEIKEEEEED GISLSSELND ILKTAIQAQS SLENSESDIE ESQKLALDLR LSSTRAASMP
ELLEQLWKAR AEKKKLRKTL REFEEAFYQQ NGRNAQKEDR VPVLEEYREY KKIKAKLRLL
EVLISKQDSS KSI
//
