ID A0A091D974_FUKDA Unreviewed; 1423 AA.
AC A0A091D974;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Latrophilin-2 {ECO:0000313|EMBL:KFO19386.1};
GN ORFNames=H920_19226 {ECO:0000313|EMBL:KFO19386.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO19386.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO19386.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO19386.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KN125096; KFO19386.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000019771; -.
DR eggNOG; KOG3545; Eukaryota.
DR eggNOG; KOG4193; Eukaryota.
DR eggNOG; KOG4729; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF61; ADHESION G PROTEIN-COUPLED RECEPTOR L2; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 1.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 793..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 832..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..919
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 939..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 999..1021
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1027..1050
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..73
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 83..342
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 416..473
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 795..1051
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 367..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1322..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1322..1353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 84..266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1423 AA; 159174 MW; 7FE1B821450149D3 CRC64;
MIESANYGRT DDKICDADPF QMENTDCYLP DAFKIMTQRC NNRTQCIVVT GSDVFPDPCP
GTYKYLEVQY ECVPYKVEQK VFVCPGTLKA IVDSPCIYEA EQKAGAWCKD PLQAADKIYF
MPWTPYRTDT LIEYASIEDF QNSRQTTTYK LPNRVDGTGF VVYDGAVFFN KERTRNIVKF
DLRTRIKSGE AIINYANYHD TSPYRWGGKT DIDLAVDENG LWVIYATEQN NGMIVISQLN
PYTLRFEATW ETVYDKRAAS NAFMVCGVLY VVRSVYQDNE SETGKNAIDY IYNTRLNRGE
YVDVPFPNQY QYIAAVDYNP RDNQLYVWNN NFILRYSLEF GPPDPAQVPT TAVTITSSAE
LFKTTVSTTT TTSQKGPVTT TVAGSQEGSK GTKPPPAAST TKIPPVTNIF PLPERFCDAL
EARGIKWPQT QRGMMVERPC PKGTRGTASY LCVVSTGTWS PKGPDLSNCT SHWVNQLAQK
IRSGENAASL ANELAKHTKG PVFAGDVSSS VRLMEQLVDI LDAQLQELKP SEKDSAGRSY
NKLQKREKTC RAYLKAIVDT VDNLLRPEAL ESWKHMNSSE QAHTATMLLD TLEEGAFVLA
DNLLEPTRVS MPTENIVLEV AVLSTEGQIQ DFKFPLGIKG AGSSIQLSAN TVKQNSRNGL
AKLVFIIYRS LGQFLSTENA TIKLGADFIG RNSTIAVNSH VISVSINKES SRVYLTDPVL
FTLPHIDPDN YFNANCSFWN YSERTMMGYW STQGCKLVDT NKTRTTCACS HLTNFAILMA
HREIVYKDGV HELLLTVITW VGIVISLVCL AICVFTFCFF RGLQSDRNTI HKNLCINLFI
AEFIFLIGID KTKYTIACPI FAGLLHFFFL AAFAWMCLEG VQLYLMLVEV FESEYSRKKY
YYVAGYLFPA TVVGVSAAID YKSYGTEKAC WLHVDNYFIW SFIGPVTFII LLNIIFLVIT
LCKMVKHSNT LKPDSSRLEN INNYRVCDGY YNTDLPGSWV LGAFALLCLL GLTWSFGLLF
VNEETIVMAY LFTIFNAFQG VFIFIFHCAL QKKVRKEYGK CFRHSYCCGG LPTESPHSSV
KASTTRTSAR YSSGTQSRIR RMWNDTVRKQ SESSFISGDI NSTSTLNQGM TGNYLLTNPL
LRPHGTNNPY NTLLAETVVC NAPSAPVFNS PGHSLNNARD TSAMDTLPLN GNFNNSYSLR
KGDYSDGVQV VDCGLSLNDT AFEKMIISEL VHNNLRGGGK THNLELALPV KPVLGGGGSE
DDALVPDASS LMHGDNPGLE LHHRELEAPL IPQRTHSLLY QPQKKVKPEG TDSYVSQLTA
EAEDHLQSPN RDSLYTSMPN LRDSPYPESS PDTEEDLSPS RRSENEDVYY KSMPNLGSGH
HQLQMCYQIS RGNSDGYIIP IHKEGCIPEG DVREGQMQLV TSL
//
