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Database: UniProt
Entry: A0A091DDI8_FUKDA
LinkDB: A0A091DDI8_FUKDA
Original site: A0A091DDI8_FUKDA 
ID   A0A091DDI8_FUKDA        Unreviewed;       832 AA.
AC   A0A091DDI8;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   07-JUN-2017, entry version 11.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=H920_10181 {ECO:0000313|EMBL:KFO28320.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO28320.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO28320.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO28320.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KN122776; KFO28320.1; -; Genomic_DNA.
DR   RefSeq; XP_010634069.1; XM_010635767.1.
DR   GeneID; 104870259; -.
DR   CTD; 10312; -.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    399    424       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    538    556       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    576    595       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    602    620       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    632    657       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    739    757       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    769    793       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
FT   COILED      247    278       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   832 AA;  92844 MW;  0017C048C2F6EDC2 CRC64;
     MGSMFRGEEV ALVQLFLPTA AAYSCVSQLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE
     LEKTFTFLQE EVRRAGLVLP QPEGKLWAPP PRDLLRLQEE TDRLAKELRD VRGNQQELQA
     QLHQLQLHEA VLGQSHGPLQ AADHTDGPSS ERSPLLPPPG GPHQDLRVNF VAGAVEPHKA
     AALERLLWRA CRSFLIASFQ EMEQQLEDPV TGEPTRWMTF LISYWGEQIG QKIRKITACF
     HCHVFPYLEQ EEARRGALQQ LQQQSQELQE VLGETERFLS QVLGRVQQLL PAAQVQIRKM
     KAVYLALNQC SVSSTHKCLI AEAWCAAHDL PTVQQVLQDS STEEGVSAVA HRIPCQDMPP
     TLIRTNRFTA SFQDIVDAYG VGRYQEVNPA PYTIITFPFL FAVMFGDVGH GLLMFLFALA
     MVLAENQPAM KAAQNEIWQT FFGGRYLLLL MGLFSVYTGF IYNECFSRAT TIFPSGWSVA
     TMANQSGWSD AFLAQHPLLT LDPNVSGVFL GPYPFGIDPV WSLATNHLSF LNSFKMKMSV
     ILGVTHMVFG VVLGIFNHMH FGQGHRLLLE TLPELIFLLG LFGYLVFLVI YKWLCYSAAS
     SASAPSILIH FINMFLFSSS STNQPLYHGQ KVVQYALVIL ALAAVPVLLL GKPLYLLRQQ
     HSHRLQRRPA GGQDEEKAKL IDTPDAAESG WGPDEEKAGC SGDEKEVEFV PSEVFMHQAI
     HTIEFCLGCI SNTASYLRLW ALSLAHAQLS EVLWAMVMRV GLSAGLKLGV QAVMLVPVFA
     AFAVLTVAIL LVMEGLSAFL HALRLHWVEF QNKFYSGTGY KLSPFTFAAQ DE
//
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