ID A0A091DF20_FUKDA Unreviewed; 997 AA.
AC A0A091DF20;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Protein unc-13 like protein C {ECO:0000313|EMBL:KFO21401.1};
GN ORFNames=H920_17195 {ECO:0000313|EMBL:KFO21401.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO21401.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO21401.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO21401.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN124379; KFO21401.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DF20; -.
DR STRING; 885580.ENSFDAP00000020616; -.
DR eggNOG; KOG1011; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:UniProt.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR027080; Unc-13.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF2; PROTEIN UNC-13 HOMOLOG C; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 394..537
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 669..811
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 827..952
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 997 AA; 113557 MW; 1C4E35CC184542D5 CRC64;
MEKLLLQALQ APKLNIWSVQ GRQSTVSLTS ECHNSTDRIK VRVWDEDDDL KSRVKQHFKK
ESDDFLGQTI VEVRTLSGEM DVWYNLEKRT DKSAVSGAIR LKINVEIKGE EKVAPYHIQY
TCLHENLFHY LTEVKSNGGV KIPEVKGDEA WKVFFDDAPQ EIVDEFAMRY GIESIYQAMT
HFSCLSSKYM CPGVPAVMST LLANINAFYA HTTATTNVQV SASDRFAATN FGREKFIKLL
DQLHNSLRID LSKYRENFPA SNSERLQDLK STVDLLTSIT FFRMKVLELQ SPPRASTVVK
DCVRACLDST YKYIFDNCHE LYAQLIDPSK KQDVPREDQG PTTKDLDFWP QLITLMVMII
DEGNAAYTPI LNQFPQELNM GKISAEIMWT LFALDMKYAL EEHQRQRFCK STEYMNLHFT
VKWFYNEYVR DLPAFKDAVP EYSLWFEPFA MQWLEENEDV SMELLHGALG RDKKDGFQQT
SDHALFSCSV VDVFAQLNQS FEIIKKLECP NPEALSHLMR RFAKTINKVL VQYAAIVSSD
FSSYCDKENV PCILMNNIQQ LRIQLEKMFE SMGGKELPYD KHKGRRCVSQ SCKVMLLAIS
LQLDPEASTI LKDLQVRLSG VLDGLSVAYG ESFQLGIEEC IKQMSFELHQ MRANGSTVSN
RNSAALDAEM VLRPLMEFLD KTLSLSAKIC EKTVLKRILK ELWKLVLNKI EKQIVLPPLT
DQGGPQMIFI AAKDLGQLSK LKEHMSREDA RGLTPRQCAV LEETLATIKQ YFHAGGNGLK
KNFLEKSPDL QSLRYALSLY TQTTDALIKK FIDTQTSQCR SSKNAVGQIS VHVDIAATPG
TGEHKVTVKV IAIHDLHWQT TAMFRPFVEV CMLGPNLGDK KRKQGTKTKS NTWSPKYNET
FQFTLSKENR PAAYELHLAV KDYCFAREDR VIGMTVIQLQ SIAEKGSHGA WYPLLRNVSV
DETGLTILRV LSQRAGDEVA KEFVRLKSEM RVAEDSA
//
