ID A0A091DG61_FUKDA Unreviewed; 1099 AA.
AC A0A091DG61;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Apoptotic protease-activating factor 1 {ECO:0000313|EMBL:KFO31134.1};
GN ORFNames=H920_07428 {ECO:0000313|EMBL:KFO31134.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO31134.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO31134.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO31134.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN122320; KFO31134.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DG61; -.
DR STRING; 885580.ENSFDAP00000010996; -.
DR eggNOG; KOG4155; Eukaryota.
DR eggNOG; KOG4658; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR048975; APAF1_WHD.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF21296; APAF-1-like_WHD; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00400; WD40; 9.
DR PRINTS; PR00364; DISEASERSIST.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 9.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000313|EMBL:KFO31134.1};
KW Protease {ECO:0000313|EMBL:KFO31134.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 29..273
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 277..344
FT /note="Apoptotic protease-activating factor 1 winged-helix"
FT /evidence="ECO:0000259|Pfam:PF21296"
FT DOMAIN 352..486
FT /note="APAF-1 helical"
FT /evidence="ECO:0000259|Pfam:PF17908"
FT REPEAT 510..551
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 552..593
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 594..637
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 638..679
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 777..809
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 898..939
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 939..979
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 980..1021
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1022..1063
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 1099 AA; 125275 MW; EAAD9D492454E905 CRC64;
MLLVRDTENL VLSKCSESKL DERENVKRKK LVAAVQQKLL KLKGEPGWVT IYGMAGCGKS
VLAAEAVRDH SLLEGCFPGG VHWVSIGKQD KSGLLMKLQN LCTRLDQDES FSQRLPLNIE
EAKDRLRILM LHKHPRSLLI LDDIWDPWVL KAFDNQCHIL LTTRDKSVTD SVMGPKYVVP
VESGLGTEKG LEILSLFVNM KKADLPEQAH SIIKECKGSP LVVSLIGALL RDFPNRWEYY
LRQLQNKQFK RIRKSSSYDY EALDEAMSIS VEMLREDIKD YYTDLSILQK DVKVPTKVLC
ILWDMETEDV EDILQEFVNK SLLFCDRNGK SFCYYLHDLQ VDFLTEKNRS QLQDLHKKMI
TQFQRYHQPH TLSSDQEDCM YWYNFLAYHM ASANMHKELC ALMFSLDWIK AKTELVGPAH
LIHEFVEYRH ILDEKDCAVC ENFQEFLSLN GHLLGRQPFP NIVQLGLCEP ETSEVYQQAK
LQAKQEVDNG MLYLEWINKK TIKNLSRLVV RPHTDAVYHA CFSEDGQRIA SCGADKTLQV
FKAETGEKLL EIKAHEDEVL CCAFSTDDRF IATCSVDKKV KIWNSVTGEL VHAYDEHSEQ
INCCCFTNNS QNLLLATASN DFFLKLWDLN QKECRNTMFG HTNSVNHCRF SPDDEVLASC
SADGTLKLWD VRSANERKSI NVKQFFLNSE DPQEDVEVVL KCCSWSADGA RMMVAARSKI
FLFDIHTSGL VAEIHTGHHS TIQYCDFSPH NRLAVVALSQ YCVELWNTDS CVKVADCRGH
LSWVHGVMFS PDGSSFLTAS DDQTIRVWET KKVCKNSAVV LKQEIDVVFQ ENEVMVLAID
NIRRLQLING KTGQIDYLTE AQGSCCCLSP HLQYIAFGDE DGAIEILELL NNKVFQSRIG
HKKAVRHIQF TADEKTLISS SDDSAIQVWN WQSEEYVLLQ GHQETVTDFR HLESSRLLSW
SFDGTVKVWN IITGRIEKDF VCHQGTVLSC DISPDATKFS STSADKTAKI WSFELPSPLH
ELKGHNGCVR CSAFSEDSSL LATGDDNGEV RWWNVLTGEA VQTFYTNGTN LRKIRVSPDF
KTYVTVDNLG ILYILQILE
//
