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Database: UniProt
Entry: A0A091DI31_FUKDA
LinkDB: A0A091DI31_FUKDA
Original site: A0A091DI31_FUKDA 
ID   A0A091DI31_FUKDA        Unreviewed;      1066 AA.
AC   A0A091DI31;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=H920_16157 {ECO:0000313|EMBL:KFO22461.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO22461.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO22461.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO22461.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KN124048; KFO22461.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF14; PTHR10037:SF14; 4.
DR   Pfam; PF00520; Ion_trans; 3.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KFO22461.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     79    102       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    150    169       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    195    214       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    226    252       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    493    512       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    518    535       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    542    564       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    665    684       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    691    715       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    721    741       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    753    781       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    857    883       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      897    932       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1066 AA;  122647 MW;  D15893FD2E71A2A3 CRC64;
     MKKRFPTSLS TSEEMLEEST LGHKEAKSLA LLIFNFSLIS ELNKSRKKCP LCWYRIAKIF
     LIWDCSPCWL KLKDFVHRII MNPFTDLFLV ICIILNIHIL ALDHYPMNED TANFLSNGSI
     LQIFKLGKYW PTFKRLMLTL GNSLMALKDL ILLLFTFIFF SAVFGMKLFG QSYKDCVCRI
     DKDCHLPRWH MHDFFHSYLL VFRILCGEWI EALWDCMEVA GQSSCVCFYM MVILIGNLLI
     LYLFLGFVSS FLSYKDATTE ESNEAKNIQL AMARIKKGIN YVLLKLLCKK QNVPKKTVDH
     VNDTYVKENI SDHALSELSN PHDFPQDKEK ISDTEKNAMT ENESQSLIPS PSFSETVPIA
     SGESDIENLD NKRIQSKSGS GESKWKIKQS SSSECSTVDI ALSEEEMVNE HEKSMHLIND
     RRRSSLGQIS KEYKKGKIWQ NIRKTCCKIV ENSWFKCFIG LVTLLSTGAL AFEDIYIDQR
     KTIKILLEYA DMIFTYIFIL EMLLKWMAYG FKAYFSNAWY RLDFMVVIVV VRALIKTTLP
     AWNVFLVCFM IWLSFSIMGV QIFAGKFYAC IDQLNGEMFS VSEVWDKTQC ESLMHNESLS
     WKNAKMNFDH VGNGFLSLLQ VNMFQGFIFD LVTNQVFNVI SMVLICLQAM IMMTESDDQS
     RQMDIALYWI NATFVMLYTV ECILKLISFH CYYFTVVWNI LDFMVVIFSI TGLLLPMTVG
     YYLVPPTLVQ LVLLSRIIHI LRLGKGPKVF RDLMLPLMLS LPALLNISLL IFLVMFIYAI
     FGMYNFAYVK KEAGINDVSN FETFGSSMIC LFQVTVFAGW DGMLYAIFNS KWSDCDPDKI
     NPGTQVRGDC GNPSVGIFYF VSYIFIIWLI IVNMYIVVIM ELLNIVSKKK TRTLSEDDFR
     KFFQVWKRFD PDRTQYIDSS QLSDFAAALD PPLFMAKPNK GQLVAMDLPM AVGDRIHCLD
     ILLAFTKRVM GKDTGMEKIL SEIESAFSLA NPFKITYEPI TTTLKRKQEA VSATIIQRAY
     KNYRSRQNDK NTSDISTLGG KQEVQAITEG ICLEKTKEKS AIRSQI
//
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