ID A0A091DJ96_FUKDA Unreviewed; 930 AA.
AC A0A091DJ96;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Methylosome protein WDR77 {ECO:0000256|ARBA:ARBA00040457};
DE AltName: Full=Methylosome protein 50 {ECO:0000256|ARBA:ARBA00041769};
DE AltName: Full=WD repeat-containing protein 77 {ECO:0000256|ARBA:ARBA00041554};
GN ORFNames=H920_15803 {ECO:0000313|EMBL:KFO22856.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO22856.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO22856.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO22856.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KN123939; KFO22856.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DJ96; -.
DR STRING; 885580.ENSFDAP00000005146; -.
DR eggNOG; KOG2806; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd02872; GH18_chitolectin_chitotriosidase; 1.
DR Gene3D; 3.10.50.10; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011583; Chitinase_II.
DR InterPro; IPR029070; Chitinase_insertion_sf.
DR InterPro; IPR001223; Glyco_hydro18_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46853; METHYLOSOME PROTEIN 50; 1.
DR PANTHER; PTHR46853:SF3; METHYLOSOME PROTEIN 50; 1.
DR Pfam; PF00704; Glyco_hydro_18; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00636; Glyco_18; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF54556; Chitinase insertion domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51910; GH18_2; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 121..162
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 163..198
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 373..736
FT /note="GH18"
FT /evidence="ECO:0000259|PROSITE:PS51910"
SQ SEQUENCE 930 AA; 101982 MW; 00DCF7C132A16A14 CRC64;
MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLAASSLS GRCWAGSLWL
FKDPCAAPNE GFCSAGVQTE AGVADLTWVG DRGILVASDS GAVELWELDE NETLIVSKFC
KYEHDDIVST VSVLSSGTQA VSGSKDFCIK IWDLAQQVVL NSYRAHAGQV TCVAASPHKD
SMFLSCSEDN RILLWDTRCP KPASQMSCSA SGYLPTSLAW HPQQSEVFVF GDENGAVSLV
DTKNASCALS SAVHTQCVTR LVFSPHSVPF LASLSEDCSL AVLDSSLSEV SPLTLAGLKL
SQTGCAHFFD CFCSTHSRGS HLTVGSGTAK QELKSIVSKQ SGIHVQHNLA QHFTIYHLLG
LALVLEHHDG AAYKLVCYFS NWAHSRPGPA SVLPHDLDPF LCSHLIFAFA SMSNNKIVAK
GLQDEKILYP EFNRLKERNK ELKTLLSIGG WNFGTMRFAT MLSTFANREK FIDSAISLLR
THNFDGLDLF FLYPGLRGSP TRDRWTFLFL IEELLFAFQK EALLTNRPRL LLSAAVSGVP
HIVQISYDVR LLGRLLDFIN ILSYDLHGSW EKFTGHNSPL FSLPEDPKSS AYAMNYWRRL
GAPSEKLLMG LPTYGRTFHL LKASKNGLQA AATGPASPGK YTKQAGFLAY YEVCSFVWRA
RKHWIDHQSV PYAYKGKEWV GYDDAISFSY KAMFVKREHF GGAMVWTLDM DDVRGTFCGT
GPFPLVNVLN EILVQAEVSS TPLPEFWSSS ATNSSRSDSE RLAVTEAMTT DTIKILPPGG
EAMATETHEK YENITTIPIS GIVTPGRETV SPRKHSVALG VKTKVPGTKT MTSVDHWSVT
AAETTVAFVH LQTETSGKKT ITTVGHQYVT PGGMTMTPVH LQTRIFGKKT MAPRRNSISP
ANGTVPFGKM SVTSAQKAVN LQGENFTQDG
//
