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Database: UniProt
Entry: A0A091DJZ9_FUKDA
LinkDB: A0A091DJZ9_FUKDA
Original site: A0A091DJZ9_FUKDA 
ID   A0A091DJZ9_FUKDA        Unreviewed;      1998 AA.
AC   A0A091DJZ9;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-OCT-2017, entry version 18.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=H920_07973 {ECO:0000313|EMBL:KFO30595.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO30595.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO30595.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO30595.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; KN122397; KFO30595.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005451; VDCC_L_a1csu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01635; LVDCCALPHA1C.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24   1998       Voltage-dependent L-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001872108.
FT   TRANSMEM     69     89       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    101    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    173    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    254    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    287    309       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    430    447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    467    490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    559    578       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    631    658       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    819    842       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    854    873       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    880    902       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    914    940       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    961    994       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1086   1112       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1163   1180       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1192   1214       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1226   1243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1319   1342       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1412   1436       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1570   1604       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      661    687       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1998 AA;  224587 MW;  BE6AF1E9A5F09589 CRC64;
     MLMLHLVVSS GVLAVALLTG ARCVCPPLLL PYAGVLTMAQ SVPELPCVHL PLVQVQGATL
     GTSQERVEYL FLIIFTVEAF LKVIAYGLLF HPNAYLRNGW NLLDFIIVVV GLFSAILEQA
     TKADGANALG GKGAGFDVKA LRAFRVLRPL RLVSGVPSLQ VVLNSIIKAM VPLLHIALLV
     LFVIIIYAII GLELFMGKMH KTCYNQEGIA DVPAEEDPSP CALESGHGRQ CQNGTVCKPG
     WDGPKHGITN FDNFAFAMLT VFQCITMEGW TDVLYWMQDA MGYELPWVYF VSLVIFGSFF
     VLNLVLGVLS GEFSKEREKA KARGDFQKLR EKQQLEEDLK GYLDWITQAE DIDPENEDEG
     MDEEKPRNMS MPTSETESVN TENVAGGDIE GENCGARLAH RISKSKFSRY WRRWNRFCRR
     KCRAAVKSNV FYWLVIFLVF LNTLTIASEH YNQPHWLTEV QDTANKALLA LFTAEMLLKM
     YSLGLQAYFV SLFNRFDCFI VCGGILETIL VETKIMSPLG ISVLRCVRLL RIFKITRYWN
     SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG KFNFDEMQTR RSTFDNFPQS
     LLTVFQILTG EDWNSVMYDG IMAYGGPSFP GMLVCIYFII LFICGNYILL NVFLAIAVDN
     LADAESLTSA QKEEEEEKER KKLARTASPE KKQEVVEKPA VEETKEEKIE LKSITADGES
     PPTIKINMDD LQHNENEDKS PYPNPDAAVL VYVSGVTKDV NSCYREGEDD EEEPEMPVGP
     RPLPLSELHL KEKAVPMPEA SAFFIFSPNN RFRLQCHRIV NDTIFTNLIL FFILLSSISL
     AAEDPVQHTS FRNHILFYFD IVFTTIFTIE IALKILGNAD YVFTSIFTLE IILKMTAYGA
     FLHKGSFCRN YFNILDLLVV SVSLISFGIQ SSAINVVKIL RVLRVLRPLR AINRAKGLKH
     VVQCVFVAIR TIGNIVIVTT LLQFMFACIG VQLFKGKLYT CSDSSKQTEA ECKGNYITYK
     DGEVDQPIIQ PRSWENSKFD FDNVLAAMMA LFTVSTFEGW PELLYRSIDS HTEDKGPIYN
     YRVEISIFFI IYIIIIAFFM MNIFVGFVIV TFQEQGEQEY KNCELDKNQR QCVEYALKAR
     PLRRYIPKNQ HQYKVWYVVN STYFEYLMFV LILLNTICLA MQHYGQSCLF KIAMNILNML
     FTGLFTVEMI LKLIAFKPKG YFSDPWNVFD FLIVIGSIID VILSETNHYF CDAWNTFDAL
     IVVGSIVDIA ITEVNNAEEN SRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL
     PYVALLIVML FFIYAVIGMQ VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD
     IMLACMPGKK CAPESEPSNS TEGETPCGSS FAVFYFISFY MLCAFLIINL FVAVIMDNFD
     YLTRDWSILG PHHLDEFKRI WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC
     KRLVSMNMPL NSDGTVMFNA TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL
     LDQVVPPAGD DEVTVGKFYA TFLIQEYFRK FKKRKEQGLV GKPSQRNALS LQAGLRTLHD
     IGPEIRRAIS GDLTAEEELD KAMKEAVSAA SEDDIFRRAG DLFGNHVSYY QSDSRSTFPQ
     TFTTQRPLHI NKAGNSQGDT ESPSHEKLVD STFTPSSYSS TGSNANINNA NNTALGRFPR
     PAGYPSMVST VEGHAPPSSP ATWAQETTRK LGAMRCHSRE SQIAVVCPEE ASQDKTYDVG
     LREDAEYCSE PSLLSTEMLA YQSDETRQLT PPEEDRRDTR PSPKRGFLRS ASLEEPSPCG
     GGGSAARRVR PVSLMVPSQT GAPGRQFHGS ASSLVEAVLI SEGLGQFAQD PKFIEVTTQE
     LADACDMTIE EMENAADNIL SGGAPQSPNG TFLPFVNCRD PGQDRAGGGD EDEGCAGALG
     RGRSEEELAD SRVHVRSL
//
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