ID A0A091DT74_FUKDA Unreviewed; 731 AA.
AC A0A091DT74;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Rac GTPase-activating protein 1 {ECO:0000313|EMBL:KFO33485.1};
GN ORFNames=H920_05146 {ECO:0000313|EMBL:KFO33485.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO33485.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO33485.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO33485.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN122084; KFO33485.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DT74; -.
DR STRING; 885580.ENSFDAP00000011567; -.
DR eggNOG; KOG3564; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20821; C1_MgcRacGAP; 1.
DR CDD; cd04382; RhoGAP_MgcRacGAP; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46199; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR PANTHER; PTHR46199:SF1; RAC GTPASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 385..434
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 448..638
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 278..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 158..206
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 731 AA; 81375 MW; 3FEC3F0D42F28613 CRC64;
MTLALYPSGS LPVVQRDLTL QLIISKSAIT LLGGDESNNH LYCTQEAAAL PFVNMASKKT
SGKGNGRPVD LSKNGCLQRR FNGTRMLNSI PSPPNCPGAK MDTMMLNLRS LFEQLVRRVE
ILSEGNELQF IQLAKDFEDF RKKWQRTDHE LGKFKDLLMK AETERSALDV KLKHARNQVD
VEIKRRQRAE ADCEKLERQI QLIREMLMCD TSGSIQLSEE QKSALAFLNR GQPTSGSAGN
KRLSTIDESG SLLSDISFDK TDESLDWDSS LVKNFKLKKR QKRRSTSQQF VDGPPGPVKK
TRSIGSTVDQ GNESIVAKTT VTVPNDGGPI EAVSTIETVP YLTRSRRKTG TLEPWNSDST
LNSRPLEPRE TGTSSTPQSN GGMRLHDFVS KTVIKPESCV PCGKRIKFGK LSLKCRDCRV
VSHPECRERC PLPCIPTLTG TPVRIGEGML ADFVSQTSPM IPSIVVHCVN EIEQRGLTET
GLYRISGCDR TVKELKEKFL RVKTVPLLSK VDDIHAVCSL LKDFLRNLKE PLLTFRLNKA
FMEAAEITDE DNSIAAMYQA VGELPQANRD TLAFLMIHLQ RVAQSPSTKM DISNLAKVFG
PTIVAHAVPN PDPMTMLQDI KRQPKVVERL LLLPLEYWSQ FMIVEQENID PLQVIENSNA
FSTPQTPDVK VSLLGPVTTP EHQLLKTPSS SSLSQRVRST LARNTPRFGS KTKSATNLGR
QGNFFASPML K
//
