ID A0A091DTW1_FUKDA Unreviewed; 732 AA.
AC A0A091DTW1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=LON peptidase N-terminal domain and RING finger protein 3 {ECO:0000313|EMBL:KFO33933.1};
GN ORFNames=H920_04658 {ECO:0000313|EMBL:KFO33933.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO33933.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO33933.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO33933.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN122036; KFO33933.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091DTW1; -.
DR STRING; 885580.ENSFDAP00000008788; -.
DR eggNOG; KOG4159; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16514; RING-HC_LONFs_rpt2; 1.
DR Gene3D; 2.30.130.40; LON domain-like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003111; Lon_prtase_N.
DR InterPro; IPR046336; Lon_prtase_N_sf.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23327:SF41; LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN 3; 1.
DR PANTHER; PTHR23327; RING FINGER PROTEIN 127; 1.
DR Pfam; PF02190; LON_substr_bdg; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00464; LON; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51787; LON_N; 1.
DR PROSITE; PS50005; TPR; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 164..197
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 440..478
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 526..726
FT /note="Lon N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51787"
FT REGION 27..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 82345 MW; 04132DC369BFD835 CRC64;
MDSFQTERML SLPAELGSNN LELAESVERE ATTAEVDTGP QQEAAIEGSE PPQMREPEQE
QPPRTSTPPE CKVLLSQADA LASGGRLREA LEVYRQLSER QQLVAEQLEQ LVRCLAENVP
QVEAQAPALA PSDGNSSTGC TVTAEEAGEA AASATELFPG PARASQLRHE GNRLYRERQV
EAALLKYNEA VRLAPNDHLL YSNRSQIYFT LESHEDALHD AEIACKLRPM GFKAHFRKAQ
ALATLGKVEE ALREFLYCVS LDVKNKRARS EAQRLLLSFF SPSVPGDSQE HSPDILKLLA
PHPRLKEHVE SMSTEGTSHN LLKLSQENPE LPHCSSQKEA SASRDGSKLM NSAKVRADGQ
QDNMKEQEEE EEKQDTASPD TASVKSGKCQ EKKRKHCQIE LREDTEVFNK AYKQDLPTDQ
GAKAALNIPL ASFDASDLEC SLCMRLFYEP VTTPCGHTFC LKCLERCLDH NAKCPLCKDG
LSQCLASRKY SKNVIMEELI AKFLPEELKE RRRLYEEEME ELSNLNKNVP IFVCTMAYPT
VPCPLHIFEP CYRLMIRRCI ETGTRQFGMC LGDPVKGFAE YGCMLEIRNV QFFADGRSVV
DSIGKRRFKV LHQGQRDGYN TADIEYIEDQ KVQGEDCAEL MGLHNCVYEQ ASLWFHSLKS
SLKNRILNHF GPMPEKDADP QINPNGPAWC WWILAVLPLE SRAQLPFLAM RSLKDRLNGI
RRVLAFISRN QN
//
