ID   A0A091DZW7_FUKDA        Unreviewed;      4656 AA.
AC   A0A091DZW7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Apolipoprotein B-100 {ECO:0000313|EMBL:KFO36003.1};
GN   ORFNames=H920_02586 {ECO:0000313|EMBL:KFO36003.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC   Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO36003.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO36003.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO36003.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Lipid
CC       droplet {ECO:0000256|ARBA:ARBA00004502}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00557}.
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DR   EMBL; KN121576; KFO36003.1; -; Genomic_DNA.
DR   STRING; 885580.ENSFDAP00000005130; -.
DR   eggNOG; KOG4338; Eukaryota.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR   GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.80.10; Lipovitellin-phosvitin complex, chain A, domain 4; 1.
DR   Gene3D; 1.25.10.20; Vitellinogen, superhelical; 1.
DR   InterPro; IPR022176; ApoB100_C.
DR   InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR   InterPro; IPR009454; Lipid_transpt_open_b-sht.
DR   InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR   InterPro; IPR015816; Vitellinogen_b-sht_N.
DR   InterPro; IPR015255; Vitellinogen_open_b-sht.
DR   InterPro; IPR001747; Vitellogenin_N.
DR   PANTHER; PTHR13769; APOLIPOPROTEIN B; 1.
DR   PANTHER; PTHR13769:SF1; APOLIPOPROTEIN B-100; 1.
DR   Pfam; PF12491; ApoB100_C; 1.
DR   Pfam; PF06448; DUF1081; 1.
DR   Pfam; PF09172; Vit_open_b-sht; 1.
DR   Pfam; PF01347; Vitellogenin_N; 1.
DR   SMART; SM01169; DUF1943; 1.
DR   SMART; SM00638; LPD_N; 1.
DR   SUPFAM; SSF48431; Lipovitellin-phosvitin complex, superhelical domain; 1.
DR   PROSITE; PS51211; VITELLOGENIN; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00557};
KW   LDL {ECO:0000256|ARBA:ARBA00022710};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Lipoprotein {ECO:0000313|EMBL:KFO36003.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..4656
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001873785"
FT   DOMAIN          129..755
FT                   /note="Vitellogenin"
FT                   /evidence="ECO:0000259|PROSITE:PS51211"
FT   DISULFID        269..295
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00557"
SQ   SEQUENCE   4656 AA;  521437 MW;  7DD707EB5B7CEFB7 CRC64;
     MSLLLTMFVQ ASRSYPCTAA REHKDTGNDL LCKAGQRVDS PVPDSARVTL ADTETGRYVG
     FHQTPQAGTK LGNSKGNIEQ DCSQIPQSTK VVEDEQFTHA SADQHGDSSF AGIPTFLNFP
     NIQEEATRFK PLRKYVYSYE AESSSGVPGT ADSRSATRIG CKVELEVPQL CSFVLKTSQC
     TLKEVYGFNP EGKALLKKTK NSEDFAAAMS KYELRLAVPE GKQVVLYPAD KEPKHILNIK
     RGMVSALLVP PETEEAEREL FLDTVYGNCS THVTVKTRKG SVATEMSTDR NLRQCSGFQP
     VSAGASPLAL IRGLARPLST LISSSQSCQY SLDPKRKHVS EATCKEQHLF LPFSYKNKYG
     MMTQVTQTWK LEDTPKTNSR FFGEGTQKVG LAFESTKSPS LPKQAEAVLK TLQELKALSV
     SEQNAQRANL FNKLVTNLRG LSNEAVSSLL PQLIEVSSPI TLQALVQCGQ PQCYTHILQW
     LKSEKAHPLL IDAVTYLVAL IPDPSVQRLR EIFSIAKEQQ SRATLYALSH VASSYFQTTH
     TVNQDLQDVA NYLQEQIRDT CAGDEDHTYL ILRVIGNMGR TLESITPAIK SSVLSCIRSP
     KPSVLIQKAA IQALRKMELG DEAQELLLQT FVDSTFPVEK RLAAYLMLMK GPSQADVNKV
     IGLLPREGNE QVKNFVASHI ANILNLEELY VGDLKTLVRE ALKDSQLPTI MDFRKYSRNY
     HFSKSVSLPL LDPVSAKIEG NLLFDPNNYL PKESMLKTTL TVFGFASADL FEIGLEGKGF
     EPTLEALFGK QGFFPDSVSK ALYWVNGQVP DHVSKVLVDH FGYTQDDKHE QDMVNGIMPI
     VNKLIKDLKS RDMPEARAYL RILGKELGFF KLQDLQFLGR LLLSGARTLQ GVPQMIGEAI
     RKGSERDLFL HYIFMDNTFE LPTGAGLQLQ VSSSGVITPG IKAGVKLEVA NMKADLLMKP
     SVSVEFVTDM SVIMPDFARS GVQMNTNFFH ESGLEARMAL KAGQLKFIIP SPQRPVKLFS
     GRNTLHLVST TKTEVIPPLI EDRQSWSACR PFIAGLSYCT TGAYSNASST QSASYYPLTG
     DTRYELELKP TGEVEQYSAS ATYELQKEDK ALVDRLKFVI QAEGVKQTEA TLMFRYNRRS
     RTLSTEMQIP DLDVNLGTVL RVSDESSKDK KSYKLNLDIQ NKKITEIAFS GHISHDTKGD
     GKIKGVVSIP RLQAEARSEI LSHWSPTKLL LQMDSSATAY GSTVSKRVMW RYDDEKIEFE
     WNTGTNVDTK KVASNFPVDL SGYLRSLEMH ARGLLHHRIP QADMSFWDMG SKLIATTNTW
     LQEASGHLPY AQILQAHLSG LTQMDLQKMS LPYFHMPDNL FLKSDGQVKY TLNKNSIEVE
     IPLPFGGKSS KDLKIFETIR TPALNFKSVG LHLPSREFQV PTFTIPELYH LRVPLLGVLT
     LSTNVYSNLY NWSASYTGGN TSRDHFTLQA RYHVKADSVV NLLSYSVQGS GETTYDHRNT
     FTLSCDGALR HKFLDSNIKL SHVEKVGNNP ASKGLLTLDA STSWGPQVSA SVHLDLKKRQ
     HLYIKDVKID GQVRASAFYA KGTYGLTCQR DPATGQLSGE SNLSFNSSYL QGTNRITGRY
     EDGALSLTST SELQGGTLKN TASLKYENYE LTLKSDTSGK SDNLAAHNKV DLTFSKQNAL
     LRSEYAADYK SLKFFSLLSG SVNSHGVELN ADVLGTDKTN AGAHKATLRI ARDGISTSAT
     TSLKYSPLFL ENELNAELGL SGASVKLTAN GRFREHSTKF TLDGKAALTE VSLGSAYQAM
     ILGVDTKNIF NFKVSGEELK LTNDLKGSYG EMTLDHTNSL HIAGLSLEFS SKLDSIYSSD
     KFYKQNFNFQ IQPFSLVTAL NNDLKYSALG LTSSGKVRLE PLKLVVDGNL KGSYQNNEIK
     HIFAVSYVDV SASCKASTVA RIQGTEFSHQ LSAGLTGLAA SVDTSTNYHS DSLRFGSAFH
     AAMAPFTLAV DAHANGNGKL AVWGEHTGQL YSKFLLKAEP LALTFSHDHK GSTNHRLLSR
     KSISTAVDHK LSVLLTPSQQ TSTWKLKTQL NDNEYSQDFD AYNTKDKIGV ELRGRGLADL
     AALDSPIKVP LFLSEPVNVL EALQMKDAVQ QPQEFTIAAV VKYDKNQDVH TISLPFFRSL
     PEYLERNRLM LITVLEAMQK ELKSIKIDQF VGKYRAGLGK LPQQVNDYLN AFSWEGQVAS
     AKEKLTAFAE NYRITENDVQ AALNNAKINL NEILSQLQTY VIQFDQYIKD NYDLYDLKVA
     IAKIIDHIIE NLKILDERYH IRVNLVRTIH NAHLFIENID FNKMGSSTAS WIQNVDIQYQ
     IRSQMQEKLQ QVRTQLQNVD IQEIAAKLKQ QVEAIDARVL LNQLRTTIPF QRIKDIIEHI
     KYFVISLIED FDVTEKINAF RAIAHELIKK YEVDQQIQVL LDKSVQLAHQ YKLKDTVQKL
     SNVLQQVDMK DCYEKLLVFV DDIIRQLKAF SFKHFLEELN QFLDILVKKL RSFDYHQFVD
     DTNHKIREVT QIINTEFQVL DLPQKAEALK LFVEDVRAML CAFLEKLKDT KINVFVNSLQ
     DALNSAHLVP IKAKFQETLE DLRDRIYQMD IQQELEHYLS LAGQVYSTLV TYISDWWVVV
     AKNLTDFAEQ YSVQAWAENV KALVEQGFTV PKIQLILGTL PAFQISLRAL QEASFQTPDF
     TVPLTDLRIP SVQINFKELK DIKIPPRFST PEFTILNTFH IPSFTIDFLE IKIKIIRTID
     QMLSSEFQWP VPEVYLGDLK VEDVLPARLV LPDFHLPEIA IPEFLIPNLN LTEFQVPDLH
     IPEFQLPPIS YTAEIPAFGK LNSILKIQSP LFTLDAKADI HNITTSEHQA GTEASIAAKG
     ESKFEVLNFD FQANAQLLNP KTNPLFLKES MNFSSKYLRM EHESEIRFSI NAIEGKSDTL
     ASLHTEKNTL ELHNGVVVKI KDRLTLDSHT KYFHKLSIPT LDFSSKADLS NAVKTLLEVG
     YITLTSSGAG SWKWACPNFS DEGTHESQIN FTVEGLLASL GVANKINSKH LKVSQNLAYE
     SGFLNFSKFE IRSDVESQHL GHSVLTAKGI ALLGKGRAEI TADHNAHLNG KVIGTLKNSL
     FISAQPLEIT ASASNEGNLK VSFPLRLTGK IDFLNDYALL VSPAAQQTSW QASAGFNQYK
     YNQNFSATNN ENSIDAHVSI NGVANLDFLN IPFTIPEMNL PYTALTTPSL KDFSIWEETG
     LKEFLKTTKQ SFDLNVSVQY KKNKDKHSIA VPLGAFYKFI SQNVNSLDSY FEDVRDKALD
     FLTTSYNEVK IKLDEYKAER SLNKLPQTFP RPGYTIPVVN VEVTPFLVET LPSGHVIPKA
     VHTPSFTIPG SDFYVPSYTL VLPSFELPDL HIPRNLLQLS LPDFKELSTV NNIFIPAMGN
     ITYDFSFKSS VITLNANAGL YNQSDLVAHF LSSSSFVIDA LQYKLEGTSR LTRKRGPKLA
     TALSLSNKFV EGSHDSTISI TKKIMEASAT TTAKVHVPVL RMNFKQELNG NTKSKPTVSS
     SIELTYDFNS PQLLSTVKGA IDHKLSLESL TSYFSIESST KGDIEGVVLS REYSGAIANE
     ASTYLSSKVT RSSVKLQGSS KVDGIWNVEL KENFAGEATL RRIYAMWEHS VKNHLQPHRH
     WSSHGEHTSK ATLELFPGSV SALIQIRARE INSVFDIPHL DQEVALNANT KHQKFSWKSE
     VQAPYGTLQH NGQLSNDQKE ARFDIAGSLE GHLHFLKFVT LPVYDKSIWD LLKLDVTTSS
     RKRQYLRAST ALVYTKNPKG YPFSVPVQEL ADKFIIPGLK LSDLSSDLAT PTFRVPFTDL
     QIPAYTLDFN EIKIYKKLST SPFALNLPAL PEVKFPQVDV LTKYSEPEES SVPFFEITVP
     EVQLTVSQFT LPKSLAVGST VLDLNEVASR VGDFELPTIT VPEQTIEIPS IKFSVPAGVF
     IPFFGTLTAH FGVASPLYNA TWNAGLKNKA DHVETFLDST CSSTLQFLEY DLNVVGTHRI
     EDGMLICKTE GMLAHHDFSA EYKEDGKYKG LEDWEGELSL DISSPAFTEL HLHYQENEKS
     VSSSAASPAI GTVGLDMETE GGRSFEFKLY FQPQSSPGQQ LNIFKTKWRY RESDDKTQMK
     FNWEEEAASR LLNSLRDNVP KATGAFHAYV DKYHREYTGL SLEDASVKLG RSLLDSAEGA
     YQRARRQIDK IDVGLQRAAS STTGAYQEWK EKAQDLYQGL LADEGQATSH RLKDKVFDSL
     LQVTQESHMA AKHMIDSSIG FLQLTRIHLP GIAGMYTRDE LCTMVMKEIG KALSQAYSNI
     QSGLEKLLSY VQDLVEKSEL IKDLQIKFPF YSESHTLTEV ILKSRKLLEF LSKEAQEVFT
     DLQSIKFSET LTELQSLLQR VFQEIEEEIK LLKETRLIHP INAIHTVFNT YIPLAFRVLK
     ESLCLNLTKF NELVQNNLQM ASEGLQQTHQ YIKALREEYF DPSVVGWTVK YYELEDKIID
     LVMDLVIALH NFHSTYAAYV TSYVSQLSAL AEQFVHKDVQ EYLFILADAD GKGKEKIAEL
     SNTAQQVIKT LITATKEIVS DYQEKFTSKL QEFPDQFSDY HEKFIAESQR VMDLFIQNYH
     MILSYITELL QKLQAATASG GNAYIKLAPG ELTVTY
//