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Database: UniProt
Entry: A0A091E6D4_FUKDA
LinkDB: A0A091E6D4_FUKDA
Original site: A0A091E6D4_FUKDA 
ID   A0A091E6D4_FUKDA        Unreviewed;      1891 AA.
AC   A0A091E6D4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   10-MAY-2017, entry version 20.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=H920_00270 {ECO:0000313|EMBL:KFO38318.1};
OS   Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
OC   Hystricomorpha; Bathyergidae; Fukomys.
OX   NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO38318.1, ECO:0000313|Proteomes:UP000028990};
RN   [1] {ECO:0000313|EMBL:KFO38318.1, ECO:0000313|Proteomes:UP000028990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Liver {ECO:0000313|EMBL:KFO38318.1};
RA   Gladyshev V.N., Fang X.;
RT   "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT   African mole rats.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KN120547; KFO38318.1; -; Genomic_DNA.
DR   Proteomes; UP000028990; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF263; PTHR10037:SF263; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000028990};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KFO38318.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    249    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    370    398       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    732    753       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    804    834       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    866    886       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    898    921       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1137   1155       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1176   1194       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1214   1233       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1264   1290       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1333   1357       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1480   1499       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1535   1563       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1631   1654       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      218    404       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      702    925       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      935   1131       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1135   1365       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1415   1664       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      406    429       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1891 AA;  213536 MW;  1CC6488CBBF940DD CRC64;
     MGPRTVRAGD EDPSVICVEI RSEDLEGDEL LSRDCPSLKY TFFLEKNEKM EFPLGSLETT
     HFRRFTPESL AEIEKQIAAH RTEKKIRDKH REQKDEEEKP RPQLDLKACN QLPKFYGELP
     AELVGEPLED LDPFYSTHRT FMVLNKGRTI SRFSATRALW LFSPFNLLRR TAIKVSVHSY
     VFTVIYTFEA LIKILARGFC LNEFTYLRDP WNWLDFSVIT LARCHRHLPT GLKVIVGALI
     HSVRKLTDVT ILTVFCLSVF ALVGLQLFKG NLKNKCVRNS TTALQATNCS SRTYEYAIKP
     GTSDPLLCGN GTGAGLCPDG YICLKTCDNP DFNYTSFDSF AWAFLSLFRL MTQDSWERLY
     QQTLRASGKI YMVFFVIVIF LGSFYLVNLI LAVVTMAYEE QNQATIAEIE AKEKKFQEAM
     EMLRKEQEVL VALGMDTASL HSGSPLASKN AGERRHRMKS RVSDGSTDDN KSPQSEPYNQ
     RRMLPKGPEN KGAEVGAGEV RSPFSEEQAP NPPPFLFIWG NAQSFLGLAS GRRRASHGSV
     FHFRAPGQDV SFPDGITDDG LCHGDHESHR GSLLLGRNAG QQGPLLRSPL SQPPNHGSQH
     GEEERPTLPA VELPPGPPEV VALDAGQRKA FLSAEYLNEP FRAQRAMSVV SIMTSVIEEL
     EESEHRCPVC LTSLAQKYLI WECCPTWVKL KAVLFELVTD PFAELIITLC IVVNTVFMAM
     EHSCMSPAFE SMLQIGNIVF TIFFTAEMVF KIIAFDPYYY FQKKWNIFDS IIVTVSLLEL
     SVVRKGSLSV LRTFRLLAKS WPTLNTLIKI IGNSVGALGN LTIILAIIVF IFALVGKQLL
     GEAYCNHQAK LTLPGDKEPR WHMMDFFHSF LIVFRILCGE WIENMWACME VSEKPICLIL
     FLTVMVLGNL VVLNLFIALL LNSFSADNLT APEDDGEVNN LQVALARLQV YGHQSRQALR
     SFFCRPCLLP RPKAELQLPA KPQLSSPKAE NHIAAEAAPG SPRALPPLRA PRDERSDLIT
     DPNLWVSVPI AEGESDLDDS EDDGEQDAPS SWQEVTPEGQ RVEDTSSSEG STVDCPDPDE
     ILRKIPELAD DLEEPDECFT EGCLRHCPCC RVNTTKFPWA MGWQLRKACY RIVEHSWFES
     FIIFMILLSS GSLAFEDCYL DQKPMVQALL EYTDRVFTFI FVFEMLLKWV AYGFKKYFTN
     AWCWLDFLIV NATAGLALQH GNISLISLIA KILKYSDMAS IKALRTLRAL RPLRALSRFE
     GMRVVVDALV GAIPSIVNVL LVCVIFWLIF SIMGVNLFAG KFGRCINRTD EEFDLVNWTV
     VNSQPKWEDN VYMYLYFVIF IIFGGFFTLN LFVGVIIDNF NQQKKKIRGQ DIFMTEEQKK
     YYNAMKKLGS KKPQKPIPRP LNKYQGFIFD IVTRQAFDIS IMVLICLNMV TMMVETDEQS
     EEKTRVLGKI NQFFVAIFTG ECVLKMFALR HYYFTNGWNV FDFIVVLLSI GSLIFSAILT
     SLENYFSPTL FRVIRLARIG RILRLIRAAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY
     SIFGMASFPH VKAEAGIDDM FNFKTFANSM LCLFQITTSA GWDGLLSPIL NTGPPYCNGT
     RGDCGNPAVG ILFFTTYIII SFLIVVNMYI AVILENFNVA TEESTEPLSE DDFDMFYETW
     EKFDPEATQF ITFSALSDFA DTLSGPLRIP KPNRNILIQM DLPLVPGDKI HCLDILFAFT
     KKVLGESGEL DTLKANMEEK FMATNISKAS YEPIATTLRW KQEDISATVI QKAYRSYMQH
     RSLVLSNSSY PTPPRVEEEA ESLPDEGFVA FMANENYVLP DKSETSSATS FPPSYDSVTR
     GLNDRVNMST SSSVQNEDEA MSKEATVSGL Q
//
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