ID A0A091E7K5_FUKDA Unreviewed; 359 AA.
AC A0A091E7K5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Transmembrane protease serine 5 {ECO:0000313|EMBL:KFO31126.1};
GN ORFNames=H920_07561 {ECO:0000313|EMBL:KFO31126.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO31126.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO31126.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO31126.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR EMBL; KN122326; KFO31126.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091E7K5; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF15494; SRCR_2; 1.
DR Pfam; PF00089; Trypsin; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF56487; SRCR-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50287; SRCR_2; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000313|EMBL:KFO31126.1};
KW Membrane {ECO:0000313|EMBL:KFO31126.1};
KW Protease {ECO:0000313|EMBL:KFO31126.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Transmembrane {ECO:0000313|EMBL:KFO31126.1}.
FT DOMAIN 91..317
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 98..129
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
SQ SEQUENCE 359 AA; 39806 MW; D1E3D1F366B3B83D CRC64;
MWESWVPDNC PQNLKPDDQV STEAQYAEEA SGPEIFRAQT GDQLQRVLYL WPAASQPTSG
ISQDEMTLSC SEASSEDALF PSLPKTVSFR ISSEDFLLEV QVRAWPDWLL VCYEGWNPVL
GVQICRSLGH LRLVHHKGVN LSDLKLSSSQ VFSQLSPGLP GELWQHSWRV HAGLVSHSTV
RPHQGAMLEK IISHPFYNAQ SHDYDIALLR LQTPLNFSGH SSDMLQDTVV PLLNTQLCNS
SCIYSGALTR RMLCAGYLDG RTDACQGDSG GPLVCPDQGT WHLVGVVSWG RGCAEPNHPG
VYAKVAEFLD WIYYTVRRPS AGLHVQAESK KKPIPVETKE QLFPYAAVGE LHALVLQCL
//
