ID A0A091EEV7_FUKDA Unreviewed; 1731 AA.
AC A0A091EEV7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Kinase D-interacting substrate of 220 kDa {ECO:0000313|EMBL:KFO33921.1};
GN ORFNames=H920_04681 {ECO:0000313|EMBL:KFO33921.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO33921.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO33921.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO33921.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN122047; KFO33921.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000012508; -.
DR eggNOG; KOG0502; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011646; KAP_P-loop.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR24116; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR PANTHER; PTHR24116:SF0; KINASE D-INTERACTING SUBSTRATE OF 220 KDA; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07693; KAP_NTPase; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 9.
DR PROSITE; PS50088; ANK_REPEAT; 10.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Kinase {ECO:0000313|EMBL:KFO33921.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:KFO33921.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 498..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..547
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 661..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 37..69
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 70..102
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 103..135
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 137..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 170..202
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 203..235
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 236..268
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 269..301
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 335..367
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 368..391
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 441..953
FT /note="KAP NTPase"
FT /evidence="ECO:0000259|Pfam:PF07693"
FT REGION 1172..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1436..1537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1550..1577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1647..1731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1731 AA; 190884 MW; 6691220B6E916FED CRC64;
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMLAAEQGN LEIVKELIKN
GANCNLEDLD NWTALISASK EGHLHVVEEL LRCGVDLEHR DMGGWTALMW ACYKGRTDVV
ELLLCHGANP SVTGLQYSVY PIIWAAGRGH ADIVHLLLQN GAKVNCSDKY GTTPLVWAAR
KGHLECVKHL LAMGADVDQE GANSMTALIV AVKGGYTQSV KEILKRNPNV NLTDKDGNTA
LMIASKEGHT EIVQDLLDAG TYVNIPDRSG DTVLIGAVRG GHVEIVRALL QKYADIDIRG
QDNKTALYWA VEKGNATMVR DILQCNPDTE ICTKDGETPL IKATKMRNIE VVELLLDKGA
KVSAVDKKGD TPLHIAIRGR SRKLAELLLR NPKDGRLLYR PNKAGETPYN IDCSHQKSIL
TQIFGARHLS PTETDGDMLG YDLYSSALAD ILSEPTMQPP ICVGLYAQWG SGKSFLLKKL
EDEMKTFAGQ QIEPLFQFSW LIVFLTLLLC GLVGLLFTFT LDLSLGVAVS LSCLALLYIF
LVVIYFGGRR EGESWNWAWV LSTRLARHIG YLELLFKLMF VNPPELPEQT TKALPVRFLF
TDYNRLSSVG GETSLAEMIA TLSDACEREF GFLATRLFRV FKTEESQGKK KWKKTCCLPS
FVIFLFLLGC IIAGITLLAV FRVDPRHLTV NAVLVSIASV VGLALVLNCR TWWQVLDSLL
NSQRKRLHHA ASTLHKLKSE GFMKVLKWEV ELMARMAKTI DGFTQNQTRL VVIIDGLDAC
EQDKVLQMLD TVRVLFSKGP FIAIFASDPH IIIKAINQNL SSVLRDSNIN GHDYMRNIVH
LPVFLNSRGL SNARKFLVTS ATNGDIACSD APGLQEDADR RVSQNSLGEL TKLGSRTALN
RRDTYRRRQM QRTITRQMSF DLTKLLVTED WFSDISPQTM RRLLNIVSVT GRLLRANQIT
FNWDRLASWI NLTEQWPYRT SWLILYLEET EGVPDQMTLK AIYERISKNI PTTKDVEPLL
EIDGDIRNFE VFLSSRTPVL VARDVKTFLP CTVNLDPKLR EIIADVRAAR EQINIGGLAY
PPLPLHEAAP RAPSGCSQPP SVCSSSTSFN GPFAGGVLSP QPHSSYYSGM TGPQHPFYNR
PFFAPYLYTP RYYPGGSQHL ISRPSVKTSL PVREQSSGLT VIQEDAAEGL PSPTDSSRGS
GPATGPVLSL NSMNVDAVCE KLKQIEGLDQ SLLPQYCTTI RKANINGRVL AQCNIDELKK
EMNMNFGDWH LFKSTILEMR NAENQAVPED PRLLPENASA AAAHGESARR SAHGAAELPH
TELSGQAPYT LNFSFEELNT LGLDEGAPRH SNLSWQSQTR RTPSLSSLTS QDSSMEISKL
TDKVQAEYRD AYREYIAQMA QLEGGPGSAA ASGRSSPHSA FDEARKPFLA KRADVLDHSS
SGVSTSDASP LDPITEEDER AEQPGSKLLP GRKGAERPSL FQTELKLKGG GLRYQKLPSD
EDESGPEESD HTPLLRESRD RRAEAQAPEL SAEPLRSLAK AKEFLSDALL DKKDSSDSGV
RSSESSPNHS LHGEVAGGAR LERADLIELD DGGRGGLPDP GLARMSICSE DKQSPSECSL
LASSPEEGWP ACHRAYNLNR TPSTVTLNNN SAPANRAGQV LDDTDGTRET SQVLLRPGPG
PAALQNENLK SLPHRRGQRT SYARLPKEPS ELHSGAPADS AGFGEERESI L
//
