ID A0A091EIM3_FUKDA Unreviewed; 494 AA.
AC A0A091EIM3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Keratin, type II cytoskeletal 8 {ECO:0000256|ARBA:ARBA00039429};
DE AltName: Full=Cytokeratin-8 {ECO:0000256|ARBA:ARBA00042964};
DE AltName: Full=Keratin-8 {ECO:0000256|ARBA:ARBA00042886};
DE AltName: Full=Type-II keratin Kb8 {ECO:0000256|ARBA:ARBA00043133};
GN ORFNames=H920_03204 {ECO:0000313|EMBL:KFO35331.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO35331.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO35331.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO35331.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Together with KRT19, helps to link the contractile apparatus
CC to dystrophin at the costameres of striated muscle.
CC {ECO:0000256|ARBA:ARBA00037766}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
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DR EMBL; KN121817; KFO35331.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091EIM3; -.
DR STRING; 885580.ENSFDAP00000014289; -.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF26; KERATIN, TYPE II CYTOSKELETAL 8; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 115..424
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 168..257
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 337..403
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 494 AA; 56405 MW; A383842646984ABB CRC64;
MWFFKKPWSH LPEAAAWLHP SLHHVHEGDP DLQGVHLWPP GFQQPLIHQW PRFPCQLLQL
LPSGQQQQLP GQPRSGRLWR CCWHGGITAV LVNQSLLNCL DLEVDPNIQA VRLQEKEQIK
TLNNKFASFI DKVRFLEQQN KMLATKWSLL QQQQTSQSNM DNMFESYNSH LRQQLDTLGQ
EKLKLEAELG NKQGLVEDFK NKYEDEINKR REIENKFVLI KKDVDEAYMN KVELESRLEL
TDEINFLRQQ YEEEICELQS QISDTSVVLS MDNSRSLDLD GIITEVKAQY EKTANLSHAE
ADSMYQIKYE ELQTLAGKHR DDLHCMKSEI SDKNHSISRL QGKIEALKGQ RASLEAAIAD
AKQRGELAIN DTNAKLAQLE GALQKAKQDM AQQLHEYQKL MNVKLVVDIE TTYHKLLEGE
ENRLEAGMQN MSIQMKTTSG YSGMVSSPYG GLPIPGFGSL QSPGFTPTKS AVVVKKIKTC
DRKLVSQTSD VLPK
//