ID A0A091EJI5_FUKDA Unreviewed; 4475 AA.
AC A0A091EJI5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Dynein heavy chain 17, axonemal {ECO:0000313|EMBL:KFO35666.1};
GN ORFNames=H920_02895 {ECO:0000313|EMBL:KFO35666.1};
OS Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Bathyergidae;
OC Fukomys.
OX NCBI_TaxID=885580 {ECO:0000313|EMBL:KFO35666.1, ECO:0000313|Proteomes:UP000028990};
RN [1] {ECO:0000313|EMBL:KFO35666.1, ECO:0000313|Proteomes:UP000028990}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Liver {ECO:0000313|EMBL:KFO35666.1};
RA Gladyshev V.N., Fang X.;
RT "The Damaraland mole rat (Fukomys damarensis) genome and evolution of
RT African mole rats.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KN121670; KFO35666.1; -; Genomic_DNA.
DR STRING; 885580.ENSFDAP00000009873; -.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000028990; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 2.
DR Pfam; PF12781; AAA_9; 2.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000028990}.
FT DOMAIN 285..856
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1348..1753
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1866..2166
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2324..2442
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2658..2719
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2764..2893
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2894..2997
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3010..3361
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3449..3614
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3651..3704
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3945..4065
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4097..4222
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4209..4473
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 864..898
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3002..3053
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3225..3281
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3694..3724
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4475 AA; 508182 MW; 223364EB05588C51 CRC64;
MLMCPRLPDA PDLALRDSGL FLKVKNGRRA KKDAEDNGDA FRKRKEASHT GAMLGDEFLT
LIMAVEWPGA HVVTVSSMEK MDHDNNEVGG IVSVKMTITP DVRLEYVEQV ASIILKFKPD
KWSKLIGAEE NIATFTEFFE KPDVSVLVLT LNAAGMIILC LGFPESLKSK GVYFIKTKPE
SINKDNYRTR LLYGDISPAP VDQLITVVEE VLHSLLNQSE NTFGWPQVVS EDIVKQVHKL
KNEMFVMGGK IKGKTLLPIP EHLGRLGSMP DSMERIPSAL NSSLLHAIET IIIDWSHQIR
DVLSKDSAQA LLDGLHPLPR VEFEFWGTRL MNLECIHEQL NRPKVNRIVE ILEKAKSCYW
PALQNVYVNV TEGLKEANDI VLYLKPLQIL LEEMEQADFT LLPSFIAKVL DTICFIWATS
EHYNTPSRVI VILQEFCNQI IDMTRSFLSP DEVLKGLQGE IEEVLDGISL SVNVLRELFR
TYDFCCANMK LFFKDKESVP WEFPSSLAFS RMNAFFHRIQ TIEDLYKTAI EFLKLEKIEL
GGVRGNILGN LVTQIYDEVF ELVKVFTDCR YDPLDPGDSS FDNDYADFET KIEDLDRRLA
TIFSQAFGDC SSIESSAKLL YMCGGLLERP LILAEVVPRY TVMLEMFDAE LDEAKFMYDA
QMAACAEGTI PPIHKNMPPV AGQLKWSLEL QERLEVSMRH IKHIEHPVVS GPEAKMIYRK
YEEMMELLRG YREKTYRQWA GGVDQDCHFN LGQPLILRSA ASGLIQVNFS KELVAVLREV
KYLNFQQQKE IPSSAESLFS ENETFRKFVG NLELIVGWYN EIKMTVMDVE FPLIKLELEA
IDVKLLSAEK TLFWNGGEGV FQYIQEMREI LYNLQNRMQK VKQNIEEITQ VMEDWSANPL
FERKDNKKEA LLDLDGRVVH LNKRYTAVKE AGVRIQAMVA ENAELFRADT ASLPWKDYVN
CLDEMVLEAL DRFIRKSLNY LISNMTVDES VAPLFEIRME LSEEGLTFNP SLEVGSDFGF
LALIDSLITD IYNVARLIPR LAKGRMNYKC LSQHVVHSKG QTDLEDTTDL IEMREELCTL
VINAMKEAEE YQDTLEKYSY LWMDDLQEFM KNFLIFGHTP TPEELDTLTQ DAVPKSPPGL
AQFQQQIDSY EKLYEEVSRC ENTRVFHSWL QCDCRPFKQA LLNTIKRWSF MFKRYLSDHV
VDSLADLEAF MKVARVGLTK PLKEGDYDGL VAVMGHLMKV RERQAATDGM FEPLTRTVEL
LKSYGEDLPE ETYLKLQELP EQWTNTKKLA FQVKQNVAPL QANEVNILRR KCQHFEQQRS
IKAMETAMEA LCKSGSLFEV TVPDYKQLKA CRREVCLLKE LWDMIVMVNS SIDDWKTTKW
RDINVEQMDI NCKKFAKDVR SLDKEMKAWD AFVGLDNTGK NMITSLRAVS ELQNPAIRER
HWQQLMQATQ VKFRMSEETT LADLLQLNLH KYEDEVRNIV DKAVKESGME KVLKALDSTW
TTMEFEHEPH PRTGTMMLKA DEVLVETLED NQVQLQNLMM SKYLSHFLKE VTGWQQKLST
ADSVIAMWFE VQRTWSHLES IFIGSEDIRA QLPKDSQRFD AIDLEFKALM EDAVKTPNVV
EATNKPGLYH KLEALKKSLA MCEKALAEYL ETKRLAFPRF YFVSSADLLD ILSNGNDPVE
VSRHLSKLFD SLCKLKFQLD ASGKPLKFGL GMYSKEDEYV EFDRECDLSG QVEVWLNRVL
DRMCATLRHE IPEAVVTYEE KPREQWIFDY PAQVRGHAAV FGIALTCTQI WWTTEVGLAF
SRLEEGYENA IKDYNKKQIS QLNALITLLI GSLSASDRMK IMTICTIDVH ARDVVAKMIT
AKARARSLHL IMGGAPAGPA GTGKTETTKD LGRALGTMVY VFNCSEQMDY KSCGNIYKGL
AQTGAWGCFD EFNRISVEVL SVIAVQVKCI QDAIRAKKKL FNFLGERISL IPTVGIFITM
NPGYAGRTEL PENLKALFRP CAMVVPDFEL ICEIMLVAEG FLEARLLARK FITLYTLCKE
LLSKQDHYDW GLRAIKSVLV VAGSLKRGDP TRAEDQVLMR ALRDFNIPKI VTDDLPVFMG
LIGDLFPALD VPRKRDLNFE KIIKQSIVEL RLQAEDSFVL KVVQLEELLQ VRHSVFVIGN
AGSGKSQVLK SLNKTYQNLK RKPVAVDLDP KAVTCDELFG IINPATREWK DGLFSTIMRD
LANITHDGPK WIVLDGDIDP MWIESLNTVM DDNKVLTLAS NERIPLNRTM RLVFEISHLR
TATPATVSRA GILYINPADL GWNPVVSSWI ERRKVQSEKA NLTILFDKYL PTCLDKLRFG
FKRITPVPEV TVIQMILYLL ECLLTEKNTP PDSPKELYEL YFVFACLWAF GGAMFQDQLV
DYRVEFSKWW INEFKTIKFP SQGTVFDYYI DPDSKKFLPW TDKVPHFELD LDVPLQASLV
HTTETTRIRY FMDLLVGKSW PVMLVGNTGS GKSVLMGEKL ESLGTDDYLV QAVPFNFYTT
SAMLQGVLEK PLEKKSGRNY GPPGNKKLIY FIDDMNMPEV DKYGTVAPHT LIRQHMDHGH
WYDRQKLTLK DIHNCQYVAC MNPTAGSFTI DPRLQRHFCV LAVSFPGQEA LVTIYSTILS
QHLAYRSAPT VIQKLSSQLV ASALELLKTP LDIVRLWLHE AERVYSDKMV DERDQDALRR
VTIASTKKFF DDLGEELLFD RPNIFCHFAQ GIGDPKYFSV TDVAHLNKLL VDALDSYNEV
NAVMNLVLFE DAVAHVCRIN RILESPRGNA LLVGVGGSGK QSLSRLAAYI SALDVFQITL
KKGYGIPDLK MDLAAQYIKA AVKNVPSVFL MTDSQVAEEQ FLVLINDLLA SGEIPGLFTD
DEVENIIASM RPQVILCFSP VGSVLRVRAR KFPAVVNCTA IDWFHEWPEA ALVSVSARFL
EETEGIQPEV KSSVSSFMAY VHTTVNEMSK TYLATERRYN YTTPKTFLEQ IKLYQSLLGK
KRMELVAKIE RLENGLMKLQ STASQVDDLK AKLAVQELEL KQKNENADKL IQVVGVETEK
VSKEKAIADE EEIKVEVINK NVTEKQQACE TDLAKAEPAL LAAQEALDTL NKNNLTELKS
FGSPPDAVVN VTAAVMTLTA PGGKIPKDKS WKAAKIMMGK VDTFLDSLKK FDKEHIPEAC
LKAFKPYQGN PTFDPEFIRS KSMAAAGLCS WCINIVRFYE VYCDVAPKRQ ALEEANAELA
EAQEKLSRIK SKIADLPDLT FQELNANLSN LTLAFEKATA EKIKCQQEAD ATSRVISLAN
RLVGGLASEN VRWAESVGNF KSQGVTLCGD VLLVSAFVSY VGYFTKKYRN ELMDKFWVPY
INSLKAEAWP ILLGLTVQSY KTCCIGQHHQ ASPAPNAGRG AIREPLSAGC QGRTAPHHRM
PSLARQVRIP ITAGLDPLSL LTDDADVATW NNQGLPSDRM STENATILCN TERWPLIVDA
QLQGIKWIKN KYGSQLKAVR LGQKSYLDII EQAISSGDIL LIENIGESVD PVLDPLLGRN
TIKKGKYIKI GGKEVEYHPN FRLILHTKYF NPHYKPEMQA QCTLINFLVT RDGLEDQLLA
AVVAKERPDL EQLKPWAPRS VGALAGWVPF LSFEARLAGF TLWLQEGPVP RRAKLTKSQN
EFKIVLKELE DSLLAHLSAA SGNFLGDTAL VENLETTKHT ASEIEEKVQE AKITEMKINE
ARENYRPAAE RASLLYFILN DLNKINPIYQ FSLKAFNVVF EKAIQKTAPA DEVRQRVINL
TDEITYSVFM YTARGLFERD KLIFLAQVTF QVLSMKKELN PVELDFLLRF PFKAGVVSPV
DFLQHQGWGG IKALAEMDEF KNLDSDIEGS AKRWKKLVES EAPEKEVFPK EWKNKTALQK
LCMVRCMRPD RMTYAVKNFV EEKMGSKFVE GRSVEFSKSY EESSPSTPIC FILSPGVDPL
KDVEALGKKL GFTIDNGKLH NVSLGQGQEV VAENALDVAA ENGHWVILQN IHLVARWLST
LDKKVERYST GSHDDYRVFI SAEPAPSPES HIIPQGILEN AIKITNEPPT GMHANLHKAL
DLFTQDTLEM CSKEIEFKCI LFALCYFHAV VAERRKFGAQ GWNRSYPFNN GDLTISINVL
YNYLEANAKV PWDDLRYLFG EIMYGGHITD DWDRRLCRTY LAEYVRMEML EGEVLLAPGF
QIPPNLDYKV KAVLDDILEK IPESFNMAEI MAKAAEKTPY VVVAFQECER MNILTNEMRR
SLKELNLGLK GELTITTDME DLSTALFYDT VPDTWVARAY PSMMGLAAWY ADLLLRIREL
EAWTTDFALP TVVWLAGFFN PQSFLTAIMQ SMARKNEWPL DKMCLSVEVT KKNREDMTAP
PREGSYVHGL FMEGARWDTQ TGVIAEARLK ELTPAMPVIF IKAVPVDRME TKNIYECPVY
KTRIRGPTYV WTFNLKTKEK AAKWILAAVA LLLQV
//
