ID A0A091EL69_CORBR Unreviewed; 1675 AA.
AC A0A091EL69;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Complement C4 {ECO:0000313|EMBL:KFO57367.1};
DE Flags: Fragment;
GN ORFNames=N302_00863 {ECO:0000313|EMBL:KFO57367.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO57367.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO57367.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO57367.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR EMBL; KK718531; KFO57367.1; -; Genomic_DNA.
DR STRING; 85066.A0A091EL69; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF86; COMPLEMENT C4-A-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1675
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001872836"
FT DOMAIN 685..720
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1537..1667
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT NON_TER 1675
FT /evidence="ECO:0000313|EMBL:KFO57367.1"
SQ SEQUENCE 1675 AA; 187980 MW; F00D3C0EFB664778 CRC64;
MERLVLLVSF CLLLSNTQQA PSFLITAPNV VHLGTHETIT VQVHGAQSPV QVTAYFKDET
KNQLVSERIY FNLNQNNGYQ EMKKIMVKPG ALQQNLFKKS NVPHVLLVTE SKELYTTVKS
TRILLSSKKG YIFIQTDKPI YTPSSQVRYR IFILDNAMRP THDTLTVAVL NSKGMVVKKL
DRKINTVVGD HFDIPDIAEP GTWKIKAWFH QHEMSNVSAE FEVKRYELPS FEVKLIPLHP
YYHIWNESFV FDIEAKHSYG KEIQGAAYVR FGIIDENENK IFIPGLEQQL SIQNGKGRVS
LNTPLLEEKL RKSISTLEGF HLYAAVTTVE TASGEMREDE LSSVKFVRSP YAVDLSNTKK
YFVPGAPFSV VASATLVDGT PAAFLFITAT VTLPGTPPMK KTAFCNREGL ASITFDIPKD
AQKLEIKVKA EEGKERLESP EASIRAERYQ SASPNYLSIS IPHTVVAPGD TLPITLNDIH
QSGSGNIGYF YYMVVTRGQA EVLGRVPASS KVINLRITEK MVPAFRFLAY YFIGNEGQQE
IVADSVWVDV MDVCEGKIKV KTEQEIYEPT DHVNLEIEMD HAGKVALAVV DKAVFILNKK
NKLTAKKVFN AMNSYDLGCS AGGGANSIQV FTDVGLAFIS DTIQSSIREG YKCLQGTRRQ
KRSLDFQKKM SGIANTYQNP DLRKCCQDGM KLSPMRFSCV KRLEKVSGSH ECRKAFQDCC
DKATALRKQA KQRNRVGLAR QYNEHEELFD ETSVTLRSYF PESWWWSFEE VESPGKHSVK
NFAPDSITTW EVQAISISPE KGFCVADPHT FAVFKDFFVS LRLPYSVRRN EQLEIKAVVY
NYLPNDLQVV VKMDAVKGLC TAETTEKAVQ LPLLAKGNSA TPAFFSVVPL IVGEIPITII
AFDQDSGHSD SIRKNLKVVA EGVLQREEET ICINSGLKSH TVDLNRPSNM VPGSDSHVLV
SLKGNIMDES VENCLSLSGV EKLIQVPTGC AEQTMVKMAP AVYAIEYLDA SEQWVNFNPE
RKQEAIGMIE KGYTRLLEFQ KEDGSYGAFK ETPSSVWLTA FIVKVLTRSR EYFSIQDSHI
INSISYLVNQ QQADGSFHDH HPVMDRSMQG GIKSAEEDLA MTAFVTIALQ QTLHVYQSPD
VARVITGTVA YMKNQFSRNT DCYSTVITAY ALTLVQSDSE DAQFVKEKLR DCSSFDGAKQ
QRYWGNGNNA VSVETTAYAL LQTLLLEDME YARPIAAWLT ERRNYGGGYC STQDTVVALE
ALSAYSIQTL NTVSTDLTVR LGTPGRQNYY SIVLTGAHEE FQKQLEFELG RKLEVSVNGK
GNGTMSILKM YWSPELKNTT CNDLILTVEV EGSLKYSEAE YSDEDDDYED LTTSGHNTSE
TLSKIDWFDI RSRRKRDVTT PSKTESLQYK VCVRSTGSKA PKMSLVDLTL LSGLEPDTKE
LEQLMTASDR YIQHYEYKEG KVLLYFGELP SGPDPDCISF GAKQINPMGL VQPANAILYD
FYNPDRKCSV FYSAPKHSAM LSKLCHANVC QCAEGPCPKQ KSTFSKALTQ TTRVSFVCYQ
PTADYAYEVE ILNSTKKNVF DYYEAKIHKI LKAAADESIQ VGDHRQFLTR SMCKLNIVPG
KRYLLMGRDG ETVDCNNKMQ YLLDAQAWVE KIPEASECRS TLRRQSCAHL QEFLS
//