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Database: UniProt
Entry: A0A091ETF2_CORBR
LinkDB: A0A091ETF2_CORBR
Original site: A0A091ETF2_CORBR 
ID   A0A091ETF2_CORBR        Unreviewed;      1949 AA.
AC   A0A091ETF2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   10-MAY-2017, entry version 17.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
DE   Flags: Fragment;
GN   ORFNames=N302_16169 {ECO:0000313|EMBL:KFO60281.1};
OS   Corvus brachyrhynchos (American crow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC   Corvus.
OX   NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO60281.1, ECO:0000313|Proteomes:UP000052976};
RN   [1] {ECO:0000313|EMBL:KFO60281.1, ECO:0000313|Proteomes:UP000052976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO60281.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KK718925; KFO60281.1; -; Genomic_DNA.
DR   Proteomes; UP000052976; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000052976};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KFO60281.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052976};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    145       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    190    209       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    221    242       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    248    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    417    444       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    774    792       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    804    827       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    839    863       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    884    912       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    974    997       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1210   1228       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1249   1271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1277   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1326   1352       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1450   1473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1531   1549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1561   1579       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1586   1611       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1648   1676       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1750   1775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      126    451       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      775   1001       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1011   1204       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1208   1482       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1530   1785       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      448    479       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KFO60281.1}.
FT   NON_TER    1949   1949       {ECO:0000313|EMBL:KFO60281.1}.
SQ   SEQUENCE   1949 AA;  219548 MW;  293E0E1ECD3315A7 CRC64;
     PGPENLRPFT PASLAAIEQR MAEAEALWIK RQQVEMPEEE EVKPSSDLEA GKNLPLIYGD
     PPLELIGIPL EDLDPFYKDK KTFIVLNKGK SIFRFSATPA LYMLGPFHPI RRGAIKVLIH
     SYPCFKLFSM FIMITILTNC VFMTLSNPPA WSKNVEYTFT GIYTFESLIK ILSRGFCIDD
     FTFLRDPWNW LDFMVISMAY ITEFVDLGNI SALRTFRVLR ALKTITVIPG LKTIVGALIQ
     SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LRQKCVRWPP PNITFLEDLG LDNNTLVNST
     FYNFMDDFTE NFTGDFTGNF TGNFTSNSTF DFEAYINDEG NYYFLEGALD ALLCGNSSDA
     GKCPEGYECM KAGRNPNYGY TSYDTFSWAF LALFRLMTQD YWENLFQLTL RAAGKTYMIF
     FVVVIFLGSF YLINLILAVV AMAYAEQNDA TMLEEQQKEE EFQQLLEQLK KQQEEQEKQV
     GGKGEGQNEG GVLGIGEGME AATSMVSNSA VECSVQGGKG KGEGEGQGEG KGRGKGKGEG
     EGEGEGKAWK SQDGLGWKGP ESSASPTPAM GHLPLPQVAP SLIHPTLPGM EGTPWSPRPL
     SDSLPSSVAG KGHDSDLNSD QDKAKDCNGQ VVPKITLQRS NTVIDVGASS VSAIPEGARP
     HRPPEGTGLC PPRRGAWNKT LHPSLLSSQF NPTYEPEKSD LNHLTVGNQE GPGLEKRVGS
     AISVISNAVE ELEEAHQKCP PWWYKFAHTF LVWNCCPPWV KLKEFVKLVV MDPFVDLGIT
     ICIVLNTLFM AMEHYPMTEE FENVLTVGNL VFTGIFTAEM VLKLIALDPY EYFQQGWNIF
     DSLIVTLSLV ELGLANVQGL SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN SVGALGNLTL
     VLAIIVFIFA VVGMQLFGKS YIECVCKISV DCTLPRWHMN DFFHSFLIVF RILCGEWIET
     MWDCMEVAGQ TMCLIVFMMV MVIGNLVVLN LFLALLLSSF SADSLAASDD DGEMNNLQIA
     IGRITRGIAF AKATLLALLR RLWKGKKVAP EEEQDPSKRD NSVLNHVDTA PEPKPGYLDG
     ITGKEHIFMD ELDHMNFINN PNLTVQVPIA SEESDLYEET STQSDTEDTT KNPLSSDNAS
     SVCSTVDYKP PAPEEEEVAE AAEESNEPEE CFTEGCVKRF PCLYVDITSE KGKIWWNLRK
     TCFRIVEHDW FETFIVFMIL LSSGALAFED IYIEQHKVIR TILEYADKVF SYVFVIEMLL
     KWVAYGFKVY FTNAWCWLDF LIVDVSLISL TANWLGYSEL GAIKSLRTLR ALRPLRALSR
     FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKYYRCVNT TTGELFDIDV
     VNNKSDCMAL LHTNEVRWVN VKVNFDNVGL GYLSLLQVAT FKGWMDIMYA AVDSREIEEQ
     PQYEINLYMY IYFVIFIIFG AFFTLNLFIG VIIDNFNQQK KKMSKDIFMT EEQKKYYNAM
     KKLGSKKPQK PIPRPSNKFQ GKVFDFVTKQ VFDITIMILI CLNMVTMMVE TDDQSELKTS
     VLYKINLVFI VIFTGECVLK MFALRYYYFT VGWNIFDFVV VILSILGIVL SDIIEKYFVS
     PTLFRVIRLA RIGRVLRLIR GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYSIFGMSN
     FAYVKKESGI DDIFNFETFG NSMICLFQIT TSAGWDGLLN PILNSGPPDC DPELENPGSS
     VKGDCGNPSI GIFFFCSYII ISFLIVVNMY IAIILENFNV ATEESSEPLC EDDFEMFYET
     WEKFDPDATQ FIAYSTLSDF VDTLQEPLRI PKPNKIKLVT MDLPMVAGDK IHCLDILFAL
     TKEVLGDSGE MDALKATMEE KFMAANPSKV SYEPITTTLK RKHEEVCATK IQRAFRRYLL
     RRSVKQASYM YRHSQDPLGE DAPEKEGLI
//
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