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Database: UniProt
Entry: A0A091EVX5_CORBR
LinkDB: A0A091EVX5_CORBR
Original site: A0A091EVX5_CORBR 
ID   A0A091EVX5_CORBR        Unreviewed;       491 AA.
AC   A0A091EVX5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   03-MAY-2023, entry version 19.
DE   RecName: Full=Wiskott-Aldrich syndrome protein family member {ECO:0000256|RuleBase:RU367034};
DE            Short=WASP family protein member {ECO:0000256|RuleBase:RU367034};
GN   ORFNames=N302_09439 {ECO:0000313|EMBL:KFO61106.1};
OS   Corvus brachyrhynchos (American crow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC   Corvus.
OX   NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO61106.1, ECO:0000313|Proteomes:UP000052976};
RN   [1] {ECO:0000313|EMBL:KFO61106.1, ECO:0000313|Proteomes:UP000052976}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO61106.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Downstream effector molecule involved in the transmission of
CC       signals from tyrosine kinase receptors and small GTPases to the actin
CC       cytoskeleton. Promotes formation of actin filaments. Part of the WAVE
CC       complex that regulates lamellipodia formation. The WAVE complex
CC       regulates actin filament reorganization via its interaction with the
CC       Arp2/3 complex. {ECO:0000256|RuleBase:RU367034}.
CC   -!- SUBUNIT: Binds actin and the Arp2/3 complex.
CC       {ECO:0000256|RuleBase:RU367034}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367034}.
CC   -!- SIMILARITY: Belongs to the SCAR/WAVE family.
CC       {ECO:0000256|ARBA:ARBA00006993, ECO:0000256|RuleBase:RU367034}.
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DR   EMBL; KK719050; KFO61106.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091EVX5; -.
DR   STRING; 85066.A0A091EVX5; -.
DR   Proteomes; UP000052976; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 6.10.280.150; -; 2.
DR   InterPro; IPR028288; SCAR/WAVE_fam.
DR   InterPro; IPR003124; WH2_dom.
DR   PANTHER; PTHR12902; WASP-1; 1.
DR   PANTHER; PTHR12902:SF1; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER; 1.
DR   Pfam; PF02205; WH2; 1.
DR   SMART; SM00246; WH2; 1.
DR   PROSITE; PS51082; WH2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|RuleBase:RU367034};
KW   Cytoplasm {ECO:0000256|RuleBase:RU367034};
KW   Cytoskeleton {ECO:0000256|RuleBase:RU367034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052976}.
FT   DOMAIN          429..446
FT                   /note="WH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51082"
FT   REGION          172..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  55164 MW;  1BA2638E023D953D CRC64;
     MPLVKRNIEP RHLCRGALPD GVTSELECVT NSTLAAIIKQ LGSLSRHAED IFGELFNEAN
     SFYMRMNSLQ ERVDLLVIKV TQLDSTVEEV SLQDINMRKA FKSSTVQNQQ VVSRNSIPNP
     VMEMYQRCDK PPPLNILTPY RDDKKDGLKF YTDPSYFFNL WKEKMLQATE DKRKEKRRQK
     EQRLVEDSTR EVKKVRKARN RRLEWNMMAY DKEFRPDNRF SPSPYHMASS EGSLSPDNSY
     ASDAADHSYP ASPNHPAQLL APASHLAPAE HKEGVLAATN PPEHVFRPAA GSRQNSLTRL
     QQPHVPPPPE AVLNGPRPHL VKDYGFYGPK LPVRLKAKSV RTAFGVTSSP IRDGVDGGFF
     PGLLPALPHS MPHSPSHQQS PTTILTLGQS FLWGSEQTKP ERSQLGAGMG GGAGMSKRVP
     SFMMPMSDAR SDLLAAIRRG IQLRKVQEQW EQEAKKEPVG NDVATILSRR IAVEYSESDD
     DSELDDNEWS D
//
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