ID A0A091EVX5_CORBR Unreviewed; 491 AA.
AC A0A091EVX5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 03-MAY-2023, entry version 19.
DE RecName: Full=Wiskott-Aldrich syndrome protein family member {ECO:0000256|RuleBase:RU367034};
DE Short=WASP family protein member {ECO:0000256|RuleBase:RU367034};
GN ORFNames=N302_09439 {ECO:0000313|EMBL:KFO61106.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO61106.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO61106.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO61106.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Downstream effector molecule involved in the transmission of
CC signals from tyrosine kinase receptors and small GTPases to the actin
CC cytoskeleton. Promotes formation of actin filaments. Part of the WAVE
CC complex that regulates lamellipodia formation. The WAVE complex
CC regulates actin filament reorganization via its interaction with the
CC Arp2/3 complex. {ECO:0000256|RuleBase:RU367034}.
CC -!- SUBUNIT: Binds actin and the Arp2/3 complex.
CC {ECO:0000256|RuleBase:RU367034}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367034}.
CC -!- SIMILARITY: Belongs to the SCAR/WAVE family.
CC {ECO:0000256|ARBA:ARBA00006993, ECO:0000256|RuleBase:RU367034}.
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DR EMBL; KK719050; KFO61106.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091EVX5; -.
DR STRING; 85066.A0A091EVX5; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 6.10.280.150; -; 2.
DR InterPro; IPR028288; SCAR/WAVE_fam.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR12902; WASP-1; 1.
DR PANTHER; PTHR12902:SF1; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00246; WH2; 1.
DR PROSITE; PS51082; WH2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|RuleBase:RU367034};
KW Cytoplasm {ECO:0000256|RuleBase:RU367034};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367034};
KW Reference proteome {ECO:0000313|Proteomes:UP000052976}.
FT DOMAIN 429..446
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 172..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 55164 MW; 1BA2638E023D953D CRC64;
MPLVKRNIEP RHLCRGALPD GVTSELECVT NSTLAAIIKQ LGSLSRHAED IFGELFNEAN
SFYMRMNSLQ ERVDLLVIKV TQLDSTVEEV SLQDINMRKA FKSSTVQNQQ VVSRNSIPNP
VMEMYQRCDK PPPLNILTPY RDDKKDGLKF YTDPSYFFNL WKEKMLQATE DKRKEKRRQK
EQRLVEDSTR EVKKVRKARN RRLEWNMMAY DKEFRPDNRF SPSPYHMASS EGSLSPDNSY
ASDAADHSYP ASPNHPAQLL APASHLAPAE HKEGVLAATN PPEHVFRPAA GSRQNSLTRL
QQPHVPPPPE AVLNGPRPHL VKDYGFYGPK LPVRLKAKSV RTAFGVTSSP IRDGVDGGFF
PGLLPALPHS MPHSPSHQQS PTTILTLGQS FLWGSEQTKP ERSQLGAGMG GGAGMSKRVP
SFMMPMSDAR SDLLAAIRRG IQLRKVQEQW EQEAKKEPVG NDVATILSRR IAVEYSESDD
DSELDDNEWS D
//