ID A0A091F624_CORBR Unreviewed; 1017 AA.
AC A0A091F624;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Rho guanine nucleotide exchange factor 18 {ECO:0000313|EMBL:KFO64686.1};
DE Flags: Fragment;
GN ORFNames=N302_05591 {ECO:0000313|EMBL:KFO64686.1};
OS Corvus brachyrhynchos (American crow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Corvidae;
OC Corvus.
OX NCBI_TaxID=85066 {ECO:0000313|EMBL:KFO64686.1, ECO:0000313|Proteomes:UP000052976};
RN [1] {ECO:0000313|EMBL:KFO64686.1, ECO:0000313|Proteomes:UP000052976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N302 {ECO:0000313|EMBL:KFO64686.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KK719666; KFO64686.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091F624; -.
DR STRING; 85066.A0A091F624; -.
DR Proteomes; UP000052976; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd15794; PH_ARHGEF18; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037744; ARHGEF18_PH.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47440:SF1; RHO_RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 18; 1.
DR PANTHER; PTHR47440; RIKEN CDNA A430078G23 GENE; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000052976}.
FT DOMAIN 127..303
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 343..445
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 557..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..815
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..922
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 950..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO64686.1"
FT NON_TER 1017
FT /evidence="ECO:0000313|EMBL:KFO64686.1"
SQ SEQUENCE 1017 AA; 115024 MW; 0B8B2C7AED967612 CRC64;
ATSLKEQPRS LLLGPDGTPA LSRNLGMTIA QRGHSQPSLN TAGAVNKFGL ISGDMDEGDS
GFIKFKQTSD DVVSLAPSTA DSIFLEDAYS VSLRSEIETD AHEFEAESWS VAVEQPYAKR
QRKDVIKRQD VIYELMQTEM HHVRTLKIML KVYSKAMLEM HGQFLLQLKE RRKESLEEGS
DRNYIIQNIG DLLVKQFSGE NGERMKEKYG VFCCGHNEAV SHYKDLLQSN KKFQNLIKKI
GNCSIVRRLG VQECILLVTQ RITKYPVLVE RIIQNTEAGT RDYEELTQAL GLIKDTITHV
DAMVNECEKG QRLKEIMHKM ELKSSGKFKN GLLFRKDDMS QRRLLLDGML YWKAASGRLK
DILAVLLTDV LLLLQEKDQK YTFASVDSKP PVISLQKLIV REVANEEKAM FLISASLKGP
EMYEIHTSSK EERNSWMAHI RRAVESCPDE EGGTFNEPEA ERRLAEARAA KLKDFQERLN
MKDDLILQSL TEKQQIYLEM SEVNGFEDHS QGSRARLLLR GDISENLQGE AILKSAVTEA
ENLQNFIFTH FGSASCQPED GSGSGLPRRG ETFGGYDSSP SVSSKSGRKN SSGDQRQWDW
RGPALSSDVQ LHDPSSDAEE GSQTSDGTRL DDSSGFQPTI ESQLVQRIQT LLQLLFSLQA
VISQQDSYIE VQRATMADRE KQYRLQSTRG NLLLEQEKQR NFEKQREELM NVQKLQSQLK
LDQQRLERER SRQQREFELT EARLQERTEE MRQLQERLSQ DREELERQRE AYQHDLERLR
EAQRAVEKEK ERLDQQKKLK KQNTVSGTFS PEMGQSQMIS HSISFNGEGV EPSPAGSKSS
VRVSSVAGLE YLERPDLVRR DSTTLENRPS LKNEVPIHLL SATNQIQKPA AVQQQIPTKL
ATFTKGSKEK GGKNKASHRT DSSASVDQKQ LLPPRLVGRE EAVLRGRRSA SPSLPSSQTP
AFQPELYGPT DAQPEALSSA SANLFKPNNV QVQPLVPSQP SLLNVQDDTS KEDVIFF
//
