ID   A0A091FP78_9AVES        Unreviewed;       946 AA.
AC   A0A091FP78;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Insulin-degrading enzyme {ECO:0000313|EMBL:KFO70974.1};
DE   Flags: Fragment;
GN   ORFNames=N303_09159 {ECO:0000313|EMBL:KFO70974.1};
OS   Cuculus canorus (common cuckoo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX   NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO70974.1, ECO:0000313|Proteomes:UP000053760};
RN   [1] {ECO:0000313|EMBL:KFO70974.1, ECO:0000313|Proteomes:UP000053760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO70974.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; KL447250; KFO70974.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091FP78; -.
DR   STRING; 55661.A0A091FP78; -.
DR   MEROPS; M16.984; -.
DR   Proteomes; UP000053760; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          36..172
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          199..377
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          383..660
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          664..847
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFO70974.1"
FT   NON_TER         946
FT                   /evidence="ECO:0000313|EMBL:KFO70974.1"
SQ   SEQUENCE   946 AA;  109515 MW;  B3910B1C86CC138A CRC64;
     NKMNNPAIKR ITNEIIKSPE DKREYRGLEL ANGIKALLIS DPTTDKSSAA LDVHIGSLSD
     PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN AFTSGEHTNY YFDVSHEHLE
     GALDRFAQFF LCPLFDESCK DREVNAVDSE HEKNLMNDAW RLFQLEKATG NPSHPFSKFG
     TGNKLTLETR PTKEGIDVRE ELLKFHSTYY SSNLMAICVL GRESLDELTC LVVKLFSEVE
     NKNVPVPEFP EHPFQEEHLR QLYKVVPIKD IRNLYVTFPI PDLQKYYKSN PGHYLGHLIG
     HEGPGSLLSE LKAKGWVNTL VGGQKEGARG FMFFIINVDL TEEGLLHVED IILHMFQYIQ
     KLRTEGPQEW VFQECKDLNA VAFRFKDKER PRGYTSKLGG MLHYYPIEEV LAAEYLLEEF
     RPDLIEMVLD KLRPENVRVA IVSKSFEGKT DRTEDWYGTQ YKQEAISDEK WQNADLNGKF
     KLPMKNEFIP TNFEILPLEK DATQYPALVK DTAMSKLWFK QDDKFFLPKA CLNFEFFSPF
     AYVDPLHCNM AYLYLELLKD SLNEYAYAAE LAGLNYDLQN TIYGMYLSVK GYNDKQHILL
     KKIIEKMATF EIDEKRFEII KEAYMRSLNN FRAEQPHQHA MYYLRLLMTE VAWTKDELKE
     ALDDVTLPRL KAFIAQLLSR LHIEALLHGN ITKQAALGIM QMVEDTLIEH AHTKPLLPSQ
     LVRYREVQLP DRGWFVYQQR NEVHNNCGIE IYYQTDMQST SENMFLELFC QIISEPCFNT
     LRTKEQLGYI VFSGPRRANG IQGLRFIIQS EKPPHYLESR VEAFLKTMEK CIEDMTEEAF
     QKHIQALAIR RLDKPKKLSA ECAKYWGEII SQQYNFDRDN IEVAYLKTLT KDDIIQFYKV
     LLAIDAPRRH KVSVHVLARE MDSCPVVGEF PCQNDVNLAP APPLPQ
//