ID A0A091FWQ4_9AVES Unreviewed; 473 AA.
AC A0A091FWQ4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 28-JUN-2023, entry version 24.
DE RecName: Full=Nicotinamide phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00035036};
DE EC=2.4.2.12 {ECO:0000256|ARBA:ARBA00035024};
DE Flags: Fragment;
GN ORFNames=N303_05881 {ECO:0000313|EMBL:KFO73521.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO73521.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO73521.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO73521.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-
CC ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and
CC nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00035007}.
CC -!- SIMILARITY: Belongs to the NAPRTase family.
CC {ECO:0000256|ARBA:ARBA00010897}.
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DR EMBL; KL447430; KFO73521.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091FWQ4; -.
DR STRING; 55661.A0A091FWQ4; -.
DR UniPathway; UPA00253; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01569; PBEF_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041529; DUF5598.
DR InterPro; IPR041525; N/Namide_PRibTrfase.
DR InterPro; IPR016471; Nicotinamide_PRibTrfase.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR PANTHER; PTHR43816; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43816:SF1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF18127; NAMPT_N; 1.
DR Pfam; PF04095; NAPRTase; 1.
DR PIRSF; PIRSF005943; NMPRT; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:KFO73521.1};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KFO73521.1}.
FT DOMAIN 1..97
FT /note="Nicotinamide phosphoribosyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18127"
FT DOMAIN 169..446
FT /note="Nicotinate/nicotinamide phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04095"
FT BINDING 177
FT /ligand="diphosphate"
FT /ligand_id="ChEBI:CHEBI:33019"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 200
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 228
FT /ligand="diphosphate"
FT /ligand_id="ChEBI:CHEBI:33019"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 292..294
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 292
FT /ligand="diphosphate"
FT /ligand_id="ChEBI:CHEBI:33019"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 334..335
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 365
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT BINDING 373
FT /ligand="beta-nicotinamide D-ribonucleotide"
FT /ligand_id="ChEBI:CHEBI:14649"
FT /evidence="ECO:0000256|PIRSR:PIRSR005943-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFO73521.1"
FT NON_TER 473
FT /evidence="ECO:0000313|EMBL:KFO73521.1"
SQ SEQUENCE 473 AA; 53545 MW; 9A2467A09F2AD9BE CRC64;
VTHYKQYPPN TSKVYSYFEC REKKTENSKL RKVKYEETVF YGLQYILNKY LKGKVVTKEK
IKEAKEVYRE HFQDDVFNEK GWNYILEKYD GHLPIEIKAV PEGSVIPRGN VLFTVENTDP
ECYWLTNWIE TILVQSWYPI TVATNSREQK KILAKYLLET SGSLEGLEYK LHDFGYRGVS
SQETAGIGAS AHLVNFKGTD TVAGIALIKK YYGTKDPVPG YSVPAAEHST ITAWGKDHEK
DAFEHIVTQF SSVPVSVVSD SYDIYNACEK IWGDDLRHII EARSPEAPLI IRPDSGNPLD
TVLKVLEILG KKFPITENSK GYKLLPPYLR VIQGDGVDIN TLQEIVEGMK KNKWSIENIA
FGSGGALLQK LTRDLLNCSF KCSYVVTNGL GVNVFKDPVA DPNKRSKKGR LSLHRTPTGD
YVTLEEGKGD LEEYGQDLLH TVFKNGKVTK SYSFDEVRQN ARLKNSELEV ASH
//
