ID A0A091G6K2_9AVES Unreviewed; 863 AA.
AC A0A091G6K2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
DE Flags: Fragment;
GN ORFNames=N303_15032 {ECO:0000313|EMBL:KFO77593.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO77593.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO77593.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO77593.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC Pro nor hydroxyproline.; EC=3.4.14.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001257};
CC -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC {ECO:0000256|ARBA:ARBA00010036}.
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DR EMBL; KL447826; KFO77593.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A091G6K2; -.
DR STRING; 55661.A0A091G6K2; -.
DR MEROPS; S09.019; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR045785; Dpp_8/9_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF109; DIPEPTIDYL PEPTIDASE 9; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF19520; Dpp_8_9_N; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053760}.
FT DOMAIN 36..163
FT /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19520"
FT DOMAIN 176..599
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 692..863
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT NON_TER 863
FT /evidence="ECO:0000313|EMBL:KFO77593.1"
SQ SEQUENCE 863 AA; 98731 MW; 8014CDF7FA062456 CRC64;
MQKIKRVRLE NETAGSWRSF LSSSEGEERM TAVDTLSDSS EVVEMEDVPS QFQVQKHSWD
GLRDIIHSSR KYSGMIVNKA PHDFQFVRKT EESSPHSHRL YYLGIPYGSR ENSLLYSEIP
KKVRKEALLL LSWKQMLDHF QATPHHGMYS REEELLRERK RLGVFGITSY DFHRESGLFL
FQASNSLFHC RDGGKNGFMV SPMKPLEIKT QCTGPRMDPK ICPADPAFFS FINNNDLWVA
NIETGEEKRM TYCHKGLSNV LDDPKSAGVA TFVIQEEFDR FTGYWWCPTA STEGSEDLKT
LRILYEEVDE SEVEIIHVPS PALEERKTDS YRYPRTGSKN PKITLKLAEF KTDAKGKIVC
AQDKELVQPF AALFPTVEYI ARAGWTRDGK YAWAMFLDRP QQRLQLILLP PALFIPVPEN
EEQRAEFAKT VPENVQPFVI YEETTDVWIN VHDIFYPFIQ PEGEEEELCF IRANECKTGF
CHLYRVTAVL KQGSYDWVQP YVHSEDDFKC PIKEEIALTS GEWEVLSRHG SKIWVNEATK
LVYFQGTKDT PLEHHLYVVS YESPGEIVRL TTPGFSHSCS MSQNFDMFIS HYSSVSTPPC
VHVYKLSGSD EDPLHKQPKF WASMMEAASC PPDYIPPEIF HFRTQSDVEL YGMIYKPHDV
QPGKKHPTVL FVYGGPQVQL VNNSFKGIKY LRLNTLASLG YAVVVIDGRG SCQRGLKFEG
ALKNQMGQVE IEDQVEGLHY VAEKYGFIDL SRVAIHGWSY GGFLSLMGLI CKPNVFKIAI
AGAPVTVWMA YDTGYTERYM DIPENNQQGY EAGSVALHVE KLPNEPNRLL ILHGFLDENV
HFFHTNFLVS QLIRAGKPYQ LQV
//
