ID   A0A091G7C2_9AVES        Unreviewed;       729 AA.
AC   A0A091G7C2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Prestin {ECO:0000256|ARBA:ARBA00040148};
DE   AltName: Full=Solute carrier family 26 member 5 {ECO:0000256|ARBA:ARBA00042390};
DE   Flags: Fragment;
GN   ORFNames=N303_09093 {ECO:0000313|EMBL:KFO78265.1};
OS   Cuculus canorus (common cuckoo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX   NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO78265.1, ECO:0000313|Proteomes:UP000053760};
RN   [1] {ECO:0000313|EMBL:KFO78265.1, ECO:0000313|Proteomes:UP000053760}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO78265.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   EMBL; KL447882; KFO78265.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A091G7C2; -.
DR   STRING; 55661.A0A091G7C2; -.
DR   Proteomes; UP000053760; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF32; PRESTIN; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        100..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        133..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        184..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        249..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        292..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        475..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          531..720
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   NON_TER         729
FT                   /evidence="ECO:0000313|EMBL:KFO78265.1"
SQ   SEQUENCE   729 AA;  79927 MW;  AD3F51085BAA450C CRC64;
     MEHAQEHEAC LEQTQKYCVE RPIYNQELLQ GKLHRRERTP QTLSQKIAHS CRCSSKKAKS
     HLYSFLPILK WLPRYPVKEY LLGDIISGIS TGVMQLPQGL AYALLAAVPP VFGLYSSFYP
     VFLYTFFGTS KHISIGTFAV ISMMVGGVAV RQVPDEIISV GYNSTNSTDS LEYYSARDAK
     RVQIAVTLAF LSGIIQLCLG LLRFGFVAIY LTEPLVRGFT TAAAVHVFTS QLKYLLGIKT
     KRYSGPLSVV YSIAAVLSKI TTTNIAALIV GLTCIVLLLV GKEINLRFKK KLPVPIPMEI
     IVVIIGTGVS AGMNLSESYR VDVVGNIPQG LRPPAVPEIQ LIPAVFVDAI AIAIVGFSMA
     VSMAKIFALK HGYTIDGNQE LIALGICNSV GSFFQSFSVT CSMSRSLVQE STGGKTQIAG
     ALSSIMVLLV IVAIGYLFEP LPQTVLAAIV MVNLKGMFKQ FGDVAHFWKT SKIELAIWVV
     AFVASLFLGL DYGLLTAVAF AMITVIYRTQ SPQYRILGQI PGTDIYCDVE EYEEVKEYPG
     IKIFQANASL YFANSDSYTS ALKKKTGVDP CAILAARRKA QKRHAREIKA ANKLRKKATN
     DVEASVKHEI ANDELPVNGK FASEDASVQD TSPDEHEHFV EPKPNIHSLI LDFTPVNFVD
     SVGAKTLKSI IKEYREVGVC VCIASCSGPA LIELTRLNFF DSTVTRELLF HSIHDAVLAC
     QVKDRSVSQ
//