ID A0A091GP43_9AVES Unreviewed; 863 AA.
AC A0A091GP43;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 4 {ECO:0000313|EMBL:KFO75862.1};
GN ORFNames=N303_05920 {ECO:0000313|EMBL:KFO75862.1};
OS Cuculus canorus (common cuckoo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Cuculiformes; Cuculidae; Cuculus.
OX NCBI_TaxID=55661 {ECO:0000313|EMBL:KFO75862.1, ECO:0000313|Proteomes:UP000053760};
RN [1] {ECO:0000313|EMBL:KFO75862.1, ECO:0000313|Proteomes:UP000053760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N303 {ECO:0000313|EMBL:KFO75862.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KL447650; KFO75862.1; -; Genomic_DNA.
DR RefSeq; XP_009558792.1; XM_009560497.1.
DR AlphaFoldDB; A0A091GP43; -.
DR STRING; 55661.A0A091GP43; -.
DR KEGG; cuca:104058912; -.
DR OrthoDB; 1003028at2759; -.
DR Proteomes; UP000053760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd22195; TRPV4; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008347; TrpV1-4.
DR InterPro; IPR008348; TrpV4.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF4; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 4; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01768; TRPVRECEPTOR.
DR PRINTS; PR01769; VRL2RECEPTOR.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:KFO75862.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 466..488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..633
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 691..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 234..266
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 472..726
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 863 AA; 97076 MW; 77282881DFF99B5E CRC64;
MADAEDPPRA MSSDAGEGLG DDGSLQNDSF PLSSLANLFE SEDTPSPAEA ARGPPGTGDG
KQNLRMKFHG AFRKGAPKPM ELLEATIYES AVVPAPKKAP MDSLFDYGTY RHHPSDNKRW
RRRVVEKQAP SAKGPAPNPP PVLKVFNRPI LFDIVSRGSP DGLDGLLSFL LTHKKRLTDE
DFREPSTGKT CLPKALLNLS GGRNDTIPIL LDIAEKTGNM REFINSPFRD VYYRGQTALH
IAIERRCKHY VELLVEKGAD VHAQARGRFF QPKDEGGYFY FGELPLSLAA CTNQPHIVHY
LTENGHKQAD LRRQDSRGNT VLHALVAIAD NTRENTKFVT KMYDLLLVKC AKLFPDTNLE
ALLNNDGLSP LMMAAKTGKI GIFQHIIRRE ITDEDARHLS RKFKDWAYGP VYSSLYDLSS
LDTCGEEVSV LEILVYNSKI ENRHEMLAVE PINELLRDKW RKFGAVSFYI SVISYLCAMV
IFTLVAYYRP MEGPPPYPYT TTADYLRLAG EIITLLTGIL FFFTNIKDLF MKKCPGVNSF
FIDGSFQLLY FIYSVLVIVT AGLYLGGIEA YLAVMVFALV LGWMNALYFT RGLKLTGTYS
IMIQKILFKD LFRFLLVYLL FMIGYASALV SLLNPCPSSE SCSEEQSNCT VPTYPSCRDS
QTFSTFLLDL FKLTIGMGDL EMLESAKYPG VFIILLVTYI ILTFVLLLNM LIALMGETVG
QVSKESKHIW KLQWATTILD IERSFPVFLR RAFRSGEMVT VGKGTNGTPD RRWCFRVDEV
NWSHWNQNLG IISEDPGKSD TYQYYGFSHT VGRLRRDRWS VVVPRVVELN KSCQPEEVVV
PLGTAGVAEA RERRHGQVSN SLL
//
